A5078332690- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular spectroscopy and chirality
- Natural product bioactivities and synthesis
- Botanical Research and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Bioactive Compounds and Antitumor Agents
- Marine Sponges and Natural Products
- Cardiovascular and exercise physiology
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Biochemical Analysis and Sensing Techniques
- Microbial Natural Products and Biosynthesis
- Bee Products Chemical Analysis
- Biological Stains and Phytochemicals
- Nutrition and Health in Aging
- Plant-derived Lignans Synthesis and Bioactivity
- Sensory Analysis and Statistical Methods
- Traditional and Medicinal Uses of Annonaceae
- Olfactory and Sensory Function Studies
- Cholesterol and Lipid Metabolism
- Microbial Metabolites in Food Biotechnology
- Exercise and Physiological Responses
Universidad Autónoma de Baja California
2019-2021
Universidad Autónoma del Estado de Hidalgo
2007-2017
Center for Research and Advanced Studies of the National Polytechnic Institute
2013
The objective of this study was to evaluate changes in color, betalain content, browning index, viscosity, physical stability, microbiological growth, antioxidant content and activity purple cactus pear juice during storage after thermoultrasonication at 80% amplitude level for 15 25 min comparison with pasteurized juice. Thermoultrasound treatment increased color stability viscosity compared (6.83 6.72 MPa, respectively), but last parameter significantly lower (p<0.05) the control juices...
The purpose of the present study was to determine optimal ultrasound conditions (amplitude level and time) for extraction cactus pear seed oil with highest antioxidant activity using a closed system. Seed analyzed yield, by ABTS DPPH, antimicrobial activity. Conventional methods were assessed comparison. Amplitude significantly affected in linear terms ( p < 0.0001 DPPH 0.001 ABTS, resp.) so, at lower amplitudes, higher achieved. optimum 78% amplitude 10 min yielded values 66.25 mg...
Chemical investigations of Acacia schaffneri led to the isolation new diterpenoid (5S,7R,8R,9R,10S)-(−)-7,8-seco-7,8-oxacassa-13,15-diene-7,17-diol (1), together with known (5S,7R,8R,9R,10S)-(−)-7,8-seco-7,8-oxacassa-13,15-dien-7-ol-17-al (2) and (5S,7R,8R,9R,10S)-(−)-7,8-seco-7,8-oxacassa-13,15-dien-7-ol (3). Compounds 2 3 were analyzed by single-crystal X-ray diffraction, while structure 1 was determined 1D 2D NMR experiments chemical correlation 2. Oxidation afforded conformationally...
An unprecedented macrocyclic dimeric diterpene containing a C2 symmetry axis was isolated from Acacia schaffneri. This compound, named schaffnerine, characterized as (5S,7S,8R,9R,10S,17S,5′S,7′S,8′R,9′R,10′S,17′S)-7,8:7,17′:16,17:17,7′:7′,8′:16′,17′-hexaepoxy-7,8-seco-7′,8′-seco-dicassa-13,13′-diene (1) its spectroscopic data. Comparison of experimental vibrational circular dichroism spectrum with that calculated using density functional theory, at the B3LYP/DGDZVP level, assigned preferred...
A methodology to determine the enantiomeric excess and absolute configuration (AC) of natural epoxythymols was developed tested using five constituents Ageratina glabrata. The is based on purity determination employing 1,1′-bi-2-naphthol (BINOL) as a chiral solvating agent combined with vibrational circular dichroism (VCD) measurements calculations. conformational searching included an extensive Monte Carlo protocol that considered rotational barriers cover whole spaces....
Cardiovascular diseases are part of the highly preventable chronic associated with changes in lifestyle. Within them, physical activity, low-fat and high-fiber diets distinguished as main support for prevention, even when supplementation nutraceuticals has become a very common practice. Fifty-two young sedentary men excess body weight (body mass index (BMI) ≥ 25 kg·m-2) were enrolled randomized-crossover controlled trial [six weeks systematic exercise Spirulina maxima or placebo (4.5...
Chromatographic purification of the antibacterial hexane, ethyl acetate and methanol extracts from aerial parts Acacia cochliacantha provided twelve known compounds: b- sitosterol, stigmasterol, b-sitosterol 3-O-b-D-glucoside, stigmasterol lupenone, taraxerone, apigenin, luteolin, querce- tin, gallic acid, methyl gallate salicylic acid whose MIC values were determined. Additionally, proacacipetalin, squalene, (+)-pinitol, palmitic, linoleic, oleic, stearic myristic acids isolated. These...
Blackberry (Rubus fruticosus spp.) fruit has high antioxidant activity due to its significant content of anthocyanins and compounds. Among emerging technologies for food preservation, thermoultrasound is a technique that reduces microbial loads releases compounds with properties. The objective this study was determine the fatty acid profile blackberry juice subjected treatment in comparison pasteurized juice. n-hexane extracts from control (untreated juice), pasteurized, thermoultrasonicated...
The diastereoselectivity of diazomethane addition to the conjugated double bond alpha,beta-unsaturated sesquiterpene lactones was explored using zaluzanin A (1) as a model. Thus, absolute configuration 1 assured by X-ray diffraction analysis including evaluation Flack and Hooft parameters, vibrational circular dichroism spectroscopy its diacetyl derivative 2, while product, pyrazoline (3), determined 1H NMR chemical shift changes with respect 1, confirmed analysis, again parameters.
Undernutrition induces an increase of the oxidative stress that can predispose offspring to various diseases in adulthood through epigenetic reprogramming. The aim this study was evaluate effects intergenerational undernutrition on protein oxidation and antioxidant defence response liver, heart brain second-generation neonates (F2 ) undernourished rats. For purpose, both parents parental (F0 first generation (F1 were fed with a low-nutrient diet. Body mass length decreased (p < 0.05) F0 , F1...
In research on natural molecules with cytotoxic activity that can be used for the development of new anticancer agents, hexane, chloroform, and methanol extracts from roots Acacia schaffneri against colon, lung, skin cancer cell lines was explored. The hexane extract showed best an average IC50 10.6 µg mL−1. From this extract, three diterpenoids, phyllocladan-16α,19-diol (1), phyllocladan-16α-ol (2), phylloclad-16-en-3-ol (3), were isolated characterized by their physical spectroscopic...
The aim of this study was to evaluate the stability color, betaxanthin, and betacyanin pigments in presence Cu(II)-dependent hydroxyl radicals (HO•) from ultrasonicated purple cactus pear juice at amplitudes 40%, 60%, 80%, comparison untreated sample. L* parameter treated 40% 80% amplitude for 25 15 min, respectively (11.3 9.3, respectively), were significantly higher compared control; b* hue parameters min showed values 1.7 0.1, respectively. Color differences (ΔE) lower (<3) juices high...
The new sesquiterpene (1R,2R,3R,6R,7S)-1-acetoxy-2,3-dihydroxy-2,3-dihydrobisabolene (3) together with ten known terpenes and three flavonoids were isolated from the aerial parts roots of Stevia tomentosa. structure 3 follows spectral studies, relative chirality at C-3 1H NMR coupling constants comparison corresponding calculated values obtained by applying a generalized Karplus-type relationship to dihedral angles model compounds, absolute configuration is assumed in analogy...
This work reports the antiproliferative activity of seco-oxacassanes 1-3, isolated from Acacia schaffneri, against human colon (HT-29), lung (A-549), and melanoma (UACC-62) cancer cell lines, as well their non-malignant counterparts CCD-841 CoN, MRC-5, VH-10, respectively, using sulforhodamine B test. While compounds 1 3 were inactive, 2 presented strong with IC50 values between 0.12 0.92 μg mL(-1). The cytotoxicity mechanisms investigated by cycle analysis through DNA repair pathways,...
Blackberry (Rubus fruticosus spp) is a fruit that has significant antioxidant activity, due to its content in anthocyanins and compounds. Emerging technologies are required as the thermoultrasound technique ensures microbial reduction release of compounds with properties. The objective this study was evaluate changes fatty acid profile blackberry juice when it subjected conservation treatment (pasteurization thermoultrasound). extracted oil n-hexane (control, pasteurized...
Life expectancy has increased unprecedentedly in recent decades, benefiting the longevity of world’s population. The most frequent pathological conditions presented this age group include excessive body fat, frailty, and hypercholesterolemia. These characteristics condition general health autonomy adults to carry out their usual activities. In sense, search for a healthy lifestyle is necessary, consisting diet that includes supplementation with nutraceuticals daily practice physical...