A5034009723- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Cancer-related gene regulation
- Muscle Physiology and Disorders
- Genomics and Chromatin Dynamics
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Genetics and Physical Performance
- CAR-T cell therapy research
- RNA Research and Splicing
- Brain Metastases and Treatment
- RNA Interference and Gene Delivery
- Genetic factors in colorectal cancer
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Virus-based gene therapy research
Seagen (United States)
2020-2023
Fred Hutch Cancer Center
2003-2017
University of Washington
2003-2010
The histone variant H2A.Z has been implicated in the regulation of gene expression, and plants antagonizes DNA methylation. Here, we ask whether a similar relationship exists mammals, using mouse B-cell lymphoma model, where chromatin states can be monitored during tumorigenesis. Using native immunoprecipitation with microarray hybridization (ChIP-chip), found progressive depletion around transcriptional start sites (TSSs) MYC-induced transformation pre-B cells and, subsequently,...
Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of DUX4 in skeletal muscle cells. a transcription factor that activates genes normally associated with stem cell biology and its FSHD cells results apoptosis. To identify pathways necessary for DUX4-mediated apoptosis, we performed an siRNA screen RD rhabdomyosarcoma line inducible transgene. Our identified components MYC-mediated apoptotic pathway double-stranded RNA (dsRNA) innate immune response as mediators DUX4-induced...
Mouse models of intestinal tumors have advanced our understanding the role gene mutations in colorectal malignancy. However, utility these systems for studying epigenetic alterations neoplasms remains to be defined. Consequently, we assessed aberrant DNA methylation azoxymethane (AOM) rodent model colon cancer. AOM induced display global hypomethylation, which is similar human We next status a panel candidate genes previously shown aberrantly methylated cancer or mouse malignant neoplasms....
Epigenetics was originally defined as the interaction of genes with their environment that brings phenotype into being. It now refers to study heritable changes in gene expression occur without a change DNA sequence. To date, best understood epigenetic mechanisms are CpG methylation and histone modifications. particular has been subject intense interest because its recently recognized role disease, well development normal function organisms. Much focus disease-related research on cancer...
Abstract Antibody-drug conjugates (ADCs) employing the vedotin drug linker are effective anti-cancer agents in multiple indications including Hodgkin lymphoma, cervical cancer, and bladder cancer. While ADCs have demonstrated efficacy for treatment of a wide variety solid hematologic cancers, some side effects, dose-limiting neutropenia, commonly observed. To improve tolerability while leveraging known activity brentuximab vedotin, an ADC approved advanced classical lymphoma other...
<h3>Background</h3> The presence of regulatory T cells (Tregs) in solid tumors attenuates the ability immune to mediate an effective response cancer. Expansion and activation intratumoral Tregs is a proposed mechanism PD-1/PD-L1 checkpoint inhibition resistance elimination these could facilitate tumors. Single cell transcriptomic flow cytometric analysis tumor-associated revealed enhanced expression CD30 on activated subset Tregs, suggesting that treatment with anti-CD30 molecule selectively...