A5015350918- Microbial Community Ecology and Physiology
- Protist diversity and phylogeny
- Methane Hydrates and Related Phenomena
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Antibiotic Resistance in Bacteria
- S100 Proteins and Annexins
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Marine and coastal ecosystems
- Antimicrobial Peptides and Activities
- Pregnancy and preeclampsia studies
- Acute Ischemic Stroke Management
University of Rhode Island
2023-2024
Haverford College
2023
UConn Health
2017-2018
The peripheral immune system plays a critical role in aging and the response to brain injury. Emerging data suggest inflammatory responses are exacerbated older animals following ischemic stroke; however, our understanding of these age-related changes is poor. In this work, we demonstrate marked differences composition circulating infiltrating leukocytes recruited old male mice after stroke compared young mice. Blood neutrophilia neutrophil invasion into were increased aged animals. Relative...
Significance Stroke is an age-related disease that disproportionately affects women. Although experimental studies have identified several hormonal and genetic factors underlying these differences, little known about how reproductive experience influences risk. This study examined the role of pregnancy parturition on neurovascular function behavior in both normal female mice females exposed to stroke. We found increases systemic metabolic risk results significant behavioral deficits are...
Abstract Anaerobic ciliates are key organisms for studying adaptations to an anaerobic lifestyle, the evolution of eukaryotic cell organelles, mechanisms energy metabolism, and symbiosis with prokaryotes; however, biodiversity their marine representatives remains poorly known. In this study, three species belonging class Plagiopylea, i.e. Trimyema foissnerisp. nov.,Plagiopyla rarisetasp. nov., Plagiopyla frontata, collected from various anoxic habitats two geographically distant continents,...
Ciliates are a diverse group of protists known for their ability to establish various partnerships and thrive in wide variety oxygen-depleted environments. Most anaerobic ciliates harbor methanogens, one the few archaea living intracellularly. These methanogens increase metabolic efficiency host fermentation via syntrophic use end-product methanogenesis. Despite ubiquity these symbioses anoxic habitats, patterns symbiont specificity fidelity not well known. We surveyed two unrelated,...
With the lack of new antibiotics in drug discovery pipeline, coupled with accelerated evolution antibiotic resistance, sources that target pathogens clinical importance are paramount. Here, we use bacterial cytological profiling to identify mechanism action monounsaturated fatty acid (
ABSTRACT Ciliates are a diverse group of protists known for their ability to establish various partnerships and thrive in wide variety oxygen-depleted environments. Most anaerobic ciliates harbor methanogens, one the few archaea living intracellularly. These methanogens increase metabolic efficiency host fermentation via syntrophic use end-product methanogenesis. Despite ubiquity these symbioses anoxic habitats, patterns symbiont specificity fidelity not well known. We surveyed two...
Abstract The association between anaerobic ciliates and methanogenic archaea has been recognized for over a century. Nevertheless, knowledge of these associations is limited to few ciliate species, so the identification patterns host–symbiont specificity largely speculative. In this study, we integrated microscopy genetic survey symbionts 32 free-living mainly from order Metopida. Based on Sanger Illumina sequencing 16S rRNA gene, our results show that single symbiont population, belonging...