A5037975569- Advancements in Transdermal Drug Delivery
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Drug Transport and Resistance Mechanisms
- Epilepsy research and treatment
- Pelvic floor disorders treatments
- Healthcare and Venom Research
- Herpesvirus Infections and Treatments
- Dermatology and Skin Diseases
- Pediatric Pain Management Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Nail Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Ocular Surface and Contact Lens
- Inflammatory mediators and NSAID effects
- Retinal Diseases and Treatments
- Bartonella species infections research
- Sphingolipid Metabolism and Signaling
- Music Therapy and Health
- Lysosomal Storage Disorders Research
- Fibroblast Growth Factor Research
- Hemodynamic Monitoring and Therapy
- Ophthalmology and Visual Impairment Studies
- Veterinary Pharmacology and Anesthesia
- Pharmacogenetics and Drug Metabolism
KK Women's and Children's Hospital
2024
Nantong University
2017-2024
Chery Automobile (China)
2023
University of Geneva
2015-2021
University of Lausanne
2015-2018
Wenzhou Medical University
2018
First Affiliated Hospital of Wenzhou Medical University
2018
Northern Jiangsu People's Hospital
2018
Tongji Hospital
2016
Southern Medical University
2015
The cytokine activin C is mainly expressed in small-diameter dorsal root ganglion (DRG) neurons and suppresses inflammatory pain. However, the effects of neuropathic pain remain elusive. Male rats wild-type TRPV1 knockout mice with peripheral nerve injury - sciatic axotomy spinal ligation rats; chronic constriction (CCI) provided models Ipsilateral lumbar (L)4-5 DRGs were assayed for expression. Chronic animals treated intrathecal or locally pre-administered vehicle. Nociceptive behaviours...
VPS34 is a class III phosphoinositide 3-kinase involved in endosomal trafficking and autophagosome formation. Inhibitors of were believed to have value as anticancer agents, but genetic pharmacological data suggest that sustained inhibition kinase activity may not be well tolerated. Here we disclose the identification novel series dihydropyrazolopyrazinone compounds represented by compound 5 potent, selective, orally bioavailable inhibitors through structure-based design strategy. A...
The targeted local delivery of anticancer therapeutics offers an alternative to systemic chemotherapy for oral cancers not amenable surgical excision. However, epithelial barrier function can pose a challenge their passive topical delivery. charged, deformable liposomes—“iontosomes”—described here are able overcome the buccal mucosal via combination electrical potential gradient imposed by iontophoresis and shape-deforming characteristics. Two chemotherapeutic agents with very different...
The purpose of this investigation was to examine the effects surgery and anesthesia on in vivo CYP3A activity portal venous blood flow. Midazolam, a probe for both rats humans, administered orally (2.7 mg), intravenously (0.57 or via vein mg) 4 h after with ketamine/xylazine placement indwelling vascular duodenal catheters 3 days (chronic). systemic clearance midazolam 51 ± ml/min/kg chronic animals, significantly decreased (29 1 ml/min/kg, <i>P</i> = 0.024) acute studied 6 surgery. hepatic...
Owing to different mechanisms of analgesia, we hypothesized that the combination ketamine and tramadol could produce synergistic or additive antinociceptive effects. Swiss albino mice were administered intraperitoneally with ketamine, tramadol, a saline, resulting effects tested in mouse tail-flick formalin tests. The potencies two drugs alone obtained by fitting data Sigmoid Emax equation. Isobolographic analysis was performed evaluate interaction. CNS depression also monitored. Results...
The objective of this study was to investigate the topical iontophoresis flurbiprofen (FBF) as a means enhance its local bioavailability and thereby provide an improved targeted treatment plantar heel pain. Initial in vitro experiments using porcine ear skin investigated iontophoretic transport FBF under different conditions. Local biodistribution rat paw vivo compared after or oral administration. Efficacy pain management incisional model by evaluating pharmacodynamic responses stimuli....
This study aimed to evaluate the optimal combination of parameters for management pain during surgical abortion using transcutaneous acupoint electrical stimulation (TEAS).This recruited patients scheduled between October 2014 and August 2015. The treatment protocol was created three levels each factor (stimulating time, acupoints, age, parity). primary outcomes were intraoperative visual analog scale (VAS), postoperative VAS, cervical relaxation degree blood loss. secondary vital...
Objectives: The development of novel long-acting injectables for local anesthetics is necessary to effectively manage the acute postoperative pain. aim this study was prepare an injectable oil-based formulation ropivacaine (ROP) prodrug (ropivacaine stearoxil, ROP-ST) and investigate pharmacokinetics pharmacodynamics after administration. Methods: A N-acyloxymethyl ROP, i.e., ROP-ST, synthesized its physicochemical properties such as log P, solubility stability characterized. soybean depot...
Objective To evaluate the clinical efficacy and safety of Levetiracetam(LEV) for prophylaxis febrile seizures(FS) recurrence in children provide a new approach to treatment. Methods Approved by their guardians, 63 cases were collected from inpatients or outpatients Jiangxi Children's Hospital Aug.to Nov.2011.They randomly divided into control group, low dose LEV group high group.When they had fever 38.5 ℃ higher, only antipyretic was given group.However, other 2 groups additionally...
Objective To investigate the effect of posteroanterior cervical mobilization with and without traction on blood flow in vertebral artery. Methods Thirty healthy female volunteers (aged 19 to 25) were recruited randomly divided into groups receive either or combined traction. The order administration was randomized, an interval 2 days between interventions. Color-flow Doppler ultrasound used measure velocity artery before after treatment. Results No significant differences...
Cannabidiol has potential for use in skin disease therapy, so it is important to know the cutaneous biodistribution of cannabidiol after topical application formulations. However, currently existing quantification methods investigation distribution are not optimal. This study aimed establish a method determination samples by UHPLC-MS/MS. A BEH C18 (50.0 × 2.1 mm, 2.5 μm) column was used; mobile phase consisted acetonitrile-0.1% formic acid (70:30, v/v), flow rate 0.2 μl·min-1 and temperature...