A5014142074- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Insect symbiosis and bacterial influences
- Viral gastroenteritis research and epidemiology
- T-cell and Retrovirus Studies
- Animal Virus Infections Studies
- Microbial infections and disease research
- Insect and Pesticide Research
- Viral Infections and Immunology Research
- Insect-Plant Interactions and Control
- Virus-based gene therapy research
- Insect behavior and control techniques
- Herpesvirus Infections and Treatments
- Chromosomal and Genetic Variations
- Aquaculture disease management and microbiota
- Milk Quality and Mastitis in Dairy Cows
- HIV Research and Treatment
- Toxoplasma gondii Research Studies
- CRISPR and Genetic Engineering
- Invertebrate Immune Response Mechanisms
- Adenosine and Purinergic Signaling
- Vibrio bacteria research studies
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Escherichia coli research studies
Griffith University
2011-2021
Royal Veterinary College
2002-2015
The University of Queensland
2004-2013
University of London
2008
Australian National University
2002-2005
Australian National Botanic Gardens
2002-2005
Commonwealth Scientific and Industrial Research Organisation
2004-2005
Université de Montréal
1998
Biotechnology and Biological Sciences Research Council
1990-1997
Hartwick College
1997
Wolbachia pipientis bacteria are common endosymbionts of insects that best known for their ability to increase prevalence in populations by manipulating host reproductive systems. However, there examples exist nature seem induce no parasitism trait and yet able invade populations. We demonstrate a fitness benefit Wolbachia-infected may explain this paradox. Drosophila melanogaster flies infected with less susceptible mortality induced range RNA viruses. The antiviral protection associated...
The complete sequence of the 1,267,782 bp genome Wolbachia pipientis wMel, an obligate intracellular bacteria Drosophila melanogaster, has been determined. Wolbachia, which are found in a variety invertebrate species, great interest due to their diverse interactions with different hosts, range from many forms reproductive parasitism mutualistic symbioses. Analysis wMel genome, particular phylogenomic comparisons other bacteria, revealed insights into biology and evolution general. For...
Three outbreaks of mucosal disease were investigated. Careful examination 47 cattle that persistently viraemic with bovine virus diarrhoea (BVDV) revealed no clinical disease, or low levels BVDV antibody and only non-cytopathic in their blood. The four animals all showed both cytopathic Following post mortem examination, there particularly high gut tissue. A hypothesis for the induction is suggested. It states become infected following utero infection when, natal life, they superinfected a...
Wolbachia are ubiquitous inherited endosymbionts of invertebrates that invade host populations by modifying reproductive systems. However, some strains lack the ability to impose modification and yet still capable successfully invading populations. To explain this paradox, theory predicts such should provide a fitness benefit, but date none has been detected. Recently completed genome sequences different show these bacteria may have genetic machinery influence iron utilization hosts. Here we...
Foot-and-Mouth Disease (FMD) is a clinical syndrome in animals due to FMD virus that exists seven serotypes, whereby recovery from one sero-type does not confer immunity against the other six. So when considering intervention strategies endemic settings, it important take account of characteristics different serotypes ecological systems. are uniformly distributed regions world where disease still occurs. For example, cumulative incidence show six (O, A, C, SAT-1, SAT-2, SAT-3) have occurred...
Epidemiological and modelling studies suggest that elimination of Onchocerca volvulus transmission (EoT) throughout Africa may not be achievable with annual mass drug administration (MDA) ivermectin alone, particularly in areas high endemicity vector density.Single-dose Phase II III clinical trials demonstrated moxidectin's superiority over for prolonged clearance O. microfilariae.We used the stochastic, individual-based EPIONCHO-IBM model to compare probabilities reaching EoT between...
ABSTRACT Wolbachia , a maternally transmitted endosymbiont of insects, is increasingly being seen as an effective biological control agent that can interfere with transmission pathogens, including dengue virus. However, the mechanism antiviral protection not well understood. The density and distribution in host tissues have been implicated contributing factors by previous studies both mosquitoes flies. Drosophila flies infected five diverse strains were screened for ability to mediate...
This paper summarises the views of a European group scientists involved in control bovine viral diarrhoea virus (BVDV), as part Union Thematic Network. The concludes that technical tools and knowledge needed to eradicate BVDV are at hand, proven by successful national schemes several countries. A generic model for is presented, which includes biosecurity, elimination persistently infected animals surveillance central elements. These elements termed 'systematic', contrast efforts without...
The outcome of microbial infection insects is dependent not only on interactions between the host and pathogen, but also microbes that co-infect host. Recently maternally inherited endosymbiotic bacteria Wolbachia has been shown to protect from a range eukaryotic pathogens. Mosquitoes experimentally infected with have upregulated immune responses are protected number pathogens including viruses, bacteria, Plasmodium filarial nematodes. It hypothesised upregulation underpins...
Most strains of the widespread endosymbiotic bacterium Wolbachia pipientis are benign or behave as reproductive parasites. The pathogenic strain wMelPop is a striking exception, however: it overreplicates in its insect hosts and causes severe life shortening. mechanism this pathogenesis currently unknown. We have sequenced genomes three variants closely related nonpathogenic wMelCS. show that wMelCS appear to be identical nonrepeat regions genome differ detectably only by triplication 19-kb...
Immunofluorescent staining and flow cytometric analysis of dendritic cells from cattle afferent lymph has established that within the veiled (ALVC) there are two phenotypically distinct, major populations. One is CD11a+, CD5+, CD21- expresses bovine WC10 (workshop cluster 10) molecule Ag recognized by mAb CC81 but not mAbs CC149 IL-A24. The second ALVC subpopulation CD11a-, CD5-, CD21+/-, workshop 10- CC149. Thus, populations, which can be identified for CD11a, defined differential...
Wolbachia is one of the most common symbionts arthropods. Its establishment requires lateral transfer to and successful transmission within novel host species. However, performs poorly when introduced into new species, models predict that should seldom be able establish from low initial frequencies. Recently, various symbionts, including Wolbachia, have been shown protect their hosts natural enemies. Hence, invasion may facilitated by dynamic interaction between it, its host, a enemy. We...
The endosymbiont Wolbachia pipientis causes diverse and sometimes dramatic phenotypes in its invertebrate hosts. Four strains sequenced to date indicate that the constitution of genome is dynamic, but these are quite divergent do not allow resolution diversification over shorter time periods. We have strain wBol1-b, found butterfly Hypolimnas bolina, which kills male offspring infected hosts during embyronic development closely related non-male-killing wPip from Culex pipiens. genomes...
ABSTRACT Wolbachia mediates antiviral protection in insect hosts and is being developed as a potential biocontrol agent to reduce the spread of insect-vectored viruses. Definition molecular mechanism that generates important for understanding tripartite interaction between host insect, , virus. Elevated oxidative stress was previously reported mosquito line experimentally infected with suggesting -mediated protection. However, introduced into mosquitoes impacts range fitness traits, some...