A5075542920- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Malaria Research and Control
- Parasitic Diseases Research and Treatment
- Insect Resistance and Genetics
- Viral Infections and Vectors
- Insect and Pesticide Research
- Insect Pest Control Strategies
- Agricultural risk and resilience
- Insect and Arachnid Ecology and Behavior
- Poverty, Education, and Child Welfare
- Invertebrate Immune Response Mechanisms
- Insect-Plant Interactions and Control
- Dengue and Mosquito Control Research
- Social Policy and Reform Studies
- Income, Poverty, and Inequality
- Trypanosoma species research and implications
- Employment and Welfare Studies
- Yersinia bacterium, plague, ectoparasites research
- CRISPR and Genetic Engineering
- Gender, Labor, and Family Dynamics
- Environmental DNA in Biodiversity Studies
- Parasites and Host Interactions
- Community Development and Social Impact
- Primate Behavior and Ecology
London School of Hygiene & Tropical Medicine
2014-2024
University of London
2015-2024
University of Warwick
2022-2024
Radboud University Nijmegen
2023-2024
Radboud University Medical Center
2023-2024
Armauer Hansen Research Institute
2024
University of Nevada, Las Vegas
2024
Università di Camerino
2023
Concordia University
2023
University of Reading
2019-2022
Mosquitoes represent the major arthropod vectors of human disease worldwide transmitting malaria, lymphatic filariasis, and arboviruses such as dengue virus Zika virus. Unfortunately, no treatment (in form vaccines or drugs) is available for most these diseases andvectorcontrolisstillthemainformofprevention. Thelimitationsoftraditionalinsecticide-based strategies, particularly development insecticide resistance, have resulted in significant efforts to develop alternative eco-friendly methods....
Introduction Dengue is one of the most widespread mosquito-borne diseases in world. The causative agent, dengue virus (DENV), primarily transmitted by mosquito Aedes aegypti, a species that has proved difficult to control using conventional methods. discovery A. aegypti transinfected with wMel strain Wolbachia showed limited DENV replication led trial field releases these mosquitoes Cairns, Australia as biocontrol strategy for virus. Methodology/Principal Findings Field collected were...
Wolbachia pipientis is an endosymbiotic bacterium estimated to chronically infect between 40–75% of all arthropod species. Aedes aegypti, the principle mosquito vector dengue virus (DENV), not a natural host Wolbachia. The transinfection strains such as wAlbB, wMel and wMelPop-CLA into Ae. aegypti has been shown significantly reduce competence this for range human pathogens in laboratory. This led wMel-transinfected currently being released five countries evaluate its effectiveness control...
Local transmission of Zika virus (ZIKV) in the Americas was first confirmed February, 2014, on Easter Island. In May, 2015, 16 patients from Brazilian states Bahia and Rio Grande do Norte were found to be ZIKV-positive. 22 countries territories have subsequently identified autochthonous within region (figure). Until recently, ZIKV infection only associated with mild symptoms (headache, rash, joint pain, conjunctivitis) but a possible link between during pregnancy subsequent birth defects...
Anopheles stephensi mosquitoes, efficient vectors in parts of Asia and Africa, were found 75.3% water sources surveyed contributed to 80.9% wild-caught mosquitoes Awash Sebat Kilo, Ethiopia. High susceptibility these Plasmodium falciparum vivax infection presents a challenge for malaria control the Horn Africa.
The obligate intracellular bacterium Wolbachia pipientis strain wPip induces cytoplasmic incompatibility (CI), patterns of crossing sterility, in the Culex pipiens group mosquitoes. complete sequence is presented 1.48-Mbp genome which encodes 1386 coding sequences (CDSs), representing first a B-supergroup Wolbachia. Comparisons were made with smaller genomes strains wMel Drosophila melanogaster, an A-supergroup that also CI inducer, and wBm, mutualist Brugia malayi nematodes belongs to...
Forty percent of the world's population is at risk contracting dengue virus, which produces fever with a potentially fatal hemorrhagic form. The wMelPop Wolbachia infection Drosophila melanogaster reduces life span and interferes viral transmission when introduced into mosquito Aedes aegypti, primary vector virus. has been proposed as an agent for preventing Population invasion by depends on levels cytoplasmic incompatibility, fitness effects, maternal transmission. Here we characterized...
Abstract Background The evolutionary importance of horizontal gene transfer (HGT) from Wolbachia endosymbiotic bacteria to their eukaryotic hosts is a topic considerable interest and debate. Recent transfers genome fragments into insect chromosomes have been reported, but it has argued that these may be on an trajectory degradation loss. Results We discovered case HGT, involving two adjacent genes, between the genomes currently -uninfected mosquito Aedes aegypti , important human disease...
Most strains of the widespread endosymbiotic bacterium Wolbachia pipientis are benign or behave as reproductive parasites. The pathogenic strain wMelPop is a striking exception, however: it overreplicates in its insect hosts and causes severe life shortening. mechanism this pathogenesis currently unknown. We have sequenced genomes three variants closely related nonpathogenic wMelCS. show that wMelCS appear to be identical nonrepeat regions genome differ detectably only by triplication 19-kb...
Abstract Insecticide resistance across sub-Saharan Africa may impact the continued effectiveness of malaria vector control. We investigated association between carbamate and pyrethroid with Anopheles gambiae s.l. parity, Plasmodium falciparum infection, molecular insecticide mechanisms in Guinea. Pyrethroid was intense, field populations surviving ten times insecticidal concentration required to kill susceptible individuals. The L1014F kdr -N1575Y haplotype I1527T mutation were significantly...
Wolbachia, a widespread bacterium that can reduce pathogen transmission in mosquitoes, has recently been reported to be present Anopheles (An.) species. In wild populations of the An. gambiae complex, primary vectors Plasmodium malaria Sub-Saharan Africa, Wolbachia DNA sequences at low density and infection frequencies have detected. As majority studies used highly sensitive nested PCR as only method detection, more robust evidence is required determine whether strains are established...
We conducted a field experiment in Southern Ghana to test the effect of asymmetric information on intrahousehold allocation. A lottery was conducted, where prizes were distributed public and private. The results indicate that over windfalls has differential observable concealable expenses, consistent with hiding. Husbands' increase investment assets social capital, while there is no such when wives win. Private both spouses are committed cash (wives) or in-kind gifts (husband) which either...
<ns4:p><ns4:bold>Background: </ns4:bold><ns4:italic>Wolbachia</ns4:italic>, a common insect endosymbiotic bacterium that can influence pathogen transmission and manipulate host reproduction, has historically been considered absent from the <ns4:italic>Anopheles (An.) </ns4:italic>genera, but recently found in <ns4:italic>An. gambiae </ns4:italic>s.l. populations West Africa. As there are numerous </ns4:italic>species have capacity to transmit malaria, we analysed range of species across five...
To identify potential sylvatic, urban and bridge-vectors that can be involved in current or future virus spillover from wild to more urbanised areas, entomological field surveys were conducted rural, peri-urban areas spanning the rainy dry seasons western Cameroon. A total of 2650 mosquitoes belonging 37 species eight genera collected. Mosquito richness was significantly influenced by specific combination habitat type season. The highest found area (S = 30, Chao1 121 ± 50.63, ACE 51.97 3.88)...
Abstract The distribution of the black rat ( Rattus rattus ) has been heavily influenced by its association with humans. dispersal history this non-native commensal rodent across Europe, however, remains poorly understood, and different introductions may have occurred during Roman medieval periods. Here, in order to reconstruct population European rats, we first generate a de novo genome assembly rat. We then sequence 67 ancient three modern mitogenomes, 36 nuclear genomes from...
Abstract Background Wolbachia are endosymbiotic bacteria that frequently found in arthropods and nematodes. These maternally inherited manipulate host reproduction by several mechanisms including cytoplasmic incompatibility (CI). CI is the most common phenotype induced results developmental arrest of embryos derived from crosses between -infected males uninfected females. Although molecular currently unknown, studies suggest sperm modified during spermatogenesis. Results We compared gene...
Control of insecticide-resistant vector populations remains a significant challenge to global malaria control and while substantial progress has been made elucidating key target site mutations, overexpressed detoxification enzymes alternate gene families, the contribution mosquito microbiota phenotypic insecticide resistance largely overlooked. We focused on determining effects deltamethrin intensity Anopheles coluzzii identifying any microbial taxa associated with phenotype.
BackgroundInsecticide resistance among malaria-vector species is a pervasive problem that might jeopardise global disease-control efforts. Novel vector-control tools with different modes of action, including long-lasting insecticidal nets (LLINs) incorporating new active ingredients, are urgently needed to delay the evolution and spread insecticide resistance. We aimed measure phenotypic genotypic insecticide-resistance profiles wild Anopheles collected over 3 years assess longitudinal...