A5101861685- Glaucoma and retinal disorders
- Retinopathy of Prematurity Studies
- Neonatal Health and Biochemistry
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Traumatic Ocular and Foreign Body Injuries
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Neonatal Respiratory Health Research
- Selenium in Biological Systems
- Trace Elements in Health
- Herbal Medicine Research Studies
- Corneal Surgery and Treatments
- Muscle metabolism and nutrition
- Retinal Development and Disorders
- TGF-β signaling in diseases
- Facial Trauma and Fracture Management
- Ocular Infections and Treatments
- Retinoids in leukemia and cellular processes
- Pharmacological Effects of Natural Compounds
- Kruppel-like factors research
- RNA modifications and cancer
- Redox biology and oxidative stress
- Craniofacial Disorders and Treatments
Gandhi Medical College
2017-2025
Hamidia Hospital
2024-2025
Alnylam Pharmaceuticals (United States)
2021-2024
University of California, San Diego
2021-2024
Creative Commons
2023
New York University
1999-2021
All India Institute of Medical Sciences
2017
Rutgers, The State University of New Jersey
2012-2016
Johnson University
2010-2016
All India Institute of Medical Sciences Bhopal
2015
Purpose: Ocular trauma constitutes an important cause of preventable visual morbidity worldwide. This study was done to the incidence, sociodemographic pattern, and clinical profile ocular in pediatric age group. Also evaluate factors influencing final outcome these patients. Methods: a prospective interventional concerning patients up 16 years either sex. Various variables having impact on were studied, results analyzed using statistical indices – relative risk, Chi-square test, P value,...
Abstract Identifying genetic variants associated with lower waist-to-hip ratio can reveal new therapeutic targets for abdominal obesity. We use exome sequences from 362,679 individuals to identify genes adjusted BMI (WHRadjBMI), a surrogate fat that is causally linked type 2 diabetes and coronary heart disease. Predicted loss of function (pLOF) in INHBE associate WHRadjBMI this association replicates data AMP-T2D-GENES. encodes secreted protein, the hepatokine activin E. In vitro...
Background: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in individuals over 55, particularly developing countries. This multifactorial disease affects the macula and influenced by genetic environmental factors. study explored role serum 25-hydroxy vitamin D, C-reactive protein (CRP), ferritin as potential biomarkers AMD risk progression. A Methods: cross-sectional was conducted on 120 patients at tertiary care hospital Central India. Participants were...
Blindness among young adults due to ocular trauma has a huge socioeconomic cost and impact on the lives of such patients their families. Thus, we evaluate epidemiology etiological factors affecting outcome in penetrating eye injuries. This one-year descriptive observational study was conducted at Department Ophthalmology, Gandhi Medical College, Bhopal, involving 50 patients. The Ocular Trauma Score (OTS) used estimate final visual acuity. epidemiological, risk were analyzed using chi-square...
Abstract Purpose: The objective of this study was to the clinical and histological profiles eyelid tumors. Methods: This is an observational prospective study. A total 78 cases tumors for a period 1 year were included in History taken examination radiological investigations done as indicated, all then subjected surgical excision/incisional biopsy per size diagnosis. Histopathological lesions done, primarily reconstructed. data compiled, statistical software SPSS version 20 used analysis....
Rhizome of Curcuma longa and seeds Carum Carvi a folk medicinal plant used as have antifertility potentials. Present investigation study the effect both on hormone reproductive parameter female rat. The aqueous ethanolic extract rhizome for testing activity in Aqueous plants were administered orally to rat 30 consecutive days. Estrous cycle, hormones (LH, FSH estrogen) weight organ studied control extract-administered groups by using standard methods . albino rats after oral administration...
Activins are one of the three distinct subclasses within greater Transforming growth factor β (TGFβ) superfamily. First discovered for their critical roles in reproductive biology, activins have since been shown to alter cellular differentiation and proliferation. At present, members activin subclass include A (ActA), ActB, ActC, ActE, more distant myostatin GDF11. While biological signaling mechanisms most class well-studied, potential ActE has remained largely unknown. Here, we...
The present study was carried out to prepare and evaluate the herbal fairness cream comprising extracts of Pleurotus ostreatus, Glycyrrhiza glabra Camellia sinensis. various types formulations oil in water (O/W) base namely F1 F6 were formulated by incorporating different concentrations Stearic acid Cetyl alcohol. pH, viscosity, spreadibilty, stability prepared investigated. F3 found appropriate for preparation cream. varying ratio sinensis incorporated three (HF1, HF2 HF3). All demonstrated...
The objective of this study was to find the association between fetal hemoglobin (HbF) concentration and retinopathy prematurity (ROP) in preterm infants.In observational, prospective, longitudinal study, a total 410 infants with <36 gestational weeks <2.5 kg birth weight, who were attending ROP clinic tertiary care hospital central India for 1 year duration included. Dilated fundus examination done as per screening guidelines, staged international classification (ICROP) classification,...
Patients with diabetic retinopathy (DR) have a greater risk of blindness compared to those without diabetes. HbA1c is valuable indicator used assess the long-term management diabetes mellitus. Hence, main objective this study was explore relationship between levels and severity retinopathy. This one-year prospective observational clinical conducted at Department Ophthalmology Diabetic Clinic, Gandhi Medical College, Bhopal, involving 100 patients. Detailed medical histories related their...
The objective of this study was to identify the association between fetal hemoglobin (HbF) concentration, blood transfusion, and retinopathy prematurity (ROP) in preterm infants.This an observational, prospective study. A total 410 infants born with <36 weeks gestational age <2.0 kg birth weight a tertiary care center central India for period 1 year were included Clinical data obtained from case notes. HbF measured sample using high-performance liquid chromatography at first visit after...
Selenocysteine (Sec) is a critical residue in at least 25 human proteins that are essential for antioxidant defense and redox signaling cells. Sec inserted into cotranslationally by the recoding of an in-frame UGA termination codon to codon. In eukaryotes, this event requires several specialized factors, including dedicated, Sec-specific elongation factor called eEFSec, which binds Sec-tRNASec with high specificity delivers it ribosome selenoprotein production. Unlike most translation...
Upon discovery of the first archaeal species in 1970s, life has been subdivided into three domains: Eukarya, Archaea, and Bacteria. However, organization three-domain tree challenged following lineages such as TACK Asgard superphyla. The Superphylum emerged closest ancestor to eukaryotes, potentially improving our understanding evolution forms. We characterized transportomes their substrates within four metagenome-assembled genomes (MAGs), that is, Odin-, Thor-, Heimdall- Loki-archaeota well...
Retinopathy of prematurity (ROP) is a serious condition affecting premature infants and identifying maternal risk factors essential for its prevention. This study aimed to identify associated with ROP in preterm newborns at tertiary care center. cross-sectional was conducted between August 2021 September 2022 All low birth weight neonates attending the clinic or admitted neonatal intensive unit (NICU) were included, while term those weighing ≥2.5 kgs anterior segment/posterior segment...
All paired sensory organs arise from a common precursor domain called the pre-placodal region (PPR). In
Risk factors associated with diabetic retinopathy among patients type 2 diabetes mellitus in central India - IJCEO- Print ISSN No: 2395-1443 Online No:- 2395-1451 Article DOI 10.18231/j.ijceo.2019.080, Indian Journal of Clinical and Experimental Ophthalmology-Indian J Clin Exp Ophthalmol
Brain derived neurotrophic factor (BDNF) levels and signaling via the tyrosine receptor kinase B (TrkB) have been shown to be altered in Alzheimer’s Disease. In addition, it has reported that isoforms of TrkB can differentially affect metabolism amyloid precursor protein (APP). Conversely, Ab, a neurotoxic cleavage product APP, impair TrkB/ BDNF signaling. Therefore, we investigated whether changes observed APP were due isoform-specific effects on either expression, and/or expression...