A5072632838- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Bacterial biofilms and quorum sensing
- Machine Learning in Bioinformatics
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Lipid Membrane Structure and Behavior
- Inhalation and Respiratory Drug Delivery
- Vibrio bacteria research studies
- Spectroscopy and Quantum Chemical Studies
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2018-2022
University of Warsaw
2015
Pseudomonas aeruginosa encodes a large set of transcriptional regulators (TRs) that modulate and manage cellular metabolism to survive in variable environmental conditions including the human body. The AraC family are an abundant group TRs bacteria, mostly acting as gene expression activators, controlling diverse functions (e.g., carbon metabolism, stress response, virulence). PA3027 protein from P. has been classified silico putative AraC-type TR. Transcriptional profiling PAO1161...
Pseudomonas aeruginosa is a cause of nosocomial infections, especially in patients with cystic fibrosis and burn wounds. PAO1 strain its derivatives are widely used to study the biology this bacterium, however recent studies demonstrated differences genomes phenotypes from different laboratories.Here we report genome sequence P. PAO1161 laboratory strain, leu-, RifR, restriction-modification defective derivative, described as host IncP-8 plasmid FP2, conferring resistance mercury. Comparison...
Pseudomonas aeruginosa is a facultative human pathogen, causing acute and chronic infections that are especially dangerous for immunocompromised patients. The eradication of P. difficult due to its intrinsic antibiotic resistance mechanisms, high adaptability, genetic plasticity. bacterium possesses multilevel regulatory systems engaging huge repertoire transcriptional regulators (TRs). Among these, the MarR family encompasses number proteins, mainly acting as repressors, which involved in...
Pseudomonas aeruginosa, a human opportunistic pathogen, is common cause of nosocomial infections. Its ability to survive under different conditions relies on complex regulatory network engaging transcriptional regulators controlling metabolic pathways and capabilities efficiently use the available resources. P. aeruginosa PA3973 encodes an uncharacterized TetR family regulator. In this study, we applied transcriptome profiling (RNA-seq), genome-wide identification binding sites using...
ABSTRACT Pseudomonas aeruginosa is a common cause of nosocomial infections, especially in patients with cystic fibrosis and burn wounds. An attenuated PAO1 strain its derivatives are widely used to study the biology this bacterium, however recent studies indicated an ongoing evolution laboratory strains, highlighted by changes genomes sublines different laboratories worldwide. Here we have sequenced genome PAO1161 strain, leu -, Rif R , restriction-modification defective derivative. This...