A5103093798- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Animal Behavior and Reproduction
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
Allen Institute for Brain Science
2022
Abstract Aggression is an evolutionarily conserved, adaptive component of social behavior. Studies in male mice illustrate that aggression influenced by numerous factors including the degree to which individual finds rewarding and will work for access attack subordinate mice. While such studies have expanded our understanding molecular circuit mechanisms very little known about female aggression, owed part limited availability valid mouse models females. Here we use ethologically relevant...
ABSTRACT Protein monoaminylation is a class of posttranslational modification (PTM) that contributes to transcription, physiology and behavior. While recent analyses have focused on histones as critical substrates monoaminylation, the broader repertoire monoaminylated proteins in brain remains unclear. Here, we report development/implementation chemical probe for bioorthogonal labeling, enrichment proteomics-based detection dopaminylated brain. We identified 1,557 – many synaptic including...