A5064290456- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Protein Degradation and Inhibitors
- Cancer Research and Treatments
- Galectins and Cancer Biology
- GDF15 and Related Biomarkers
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- DNA Repair Mechanisms
- Estrogen and related hormone effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell death mechanisms and regulation
- Neurogenesis and neuroplasticity mechanisms
- Protein Tyrosine Phosphatases
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
McGill University
2023-2024
McGill University Health Centre
2022
Université du Québec à Montréal
2020-2021
Estrogen-related-receptor α (ERRα) plays a critical role in the transcriptional regulation of cellular bioenergetics and metabolism, perturbations its activity have been associated with metabolic diseases. While several coactivators corepressors ERRα identified to date, knowledge gap remains understanding extent which cooperates coregulators control gene expression. Herein, we mapped primary chromatin-bound interactome mouse liver. RIME (Rapid Immuno-precipitation Mass spectrometry...
Dendritic cells (DCs) excel at cross-presenting antigens, but their effectiveness as cancer vaccine is limited. Here, we describe a vaccination approach using mesenchymal stromal (MSCs) engineered to express the immunoproteasome complex (MSC-IPr). Such modification instills efficient antigen cross-presentation abilities associated with enhanced major histocompatibility class I and CD80 expression, de novo production of interleukin-12, higher chemokine secretion. This capacity MSC-IPr highly...
Abstract Increased understanding of the modulatory pathways controlling CD8 T cell responses has led to formulation successful checkpoint inhibitor-based immunotherapies against cancer. However, their effectiveness is limited a few tumor types, motivating search for novel combinatorial strategies. PTPN1 and PTPN2 are two homologous protein tyrosine phosphatases recently proposed as potent intracellular checkpoints. Furthermore, catalytic domain propitious target small-molecule...
We report the discovery, via a unique high-throughput screening strategy, of novel bioactive anticancer compound: Thiol Alkylating Compound Inducing Massive Apoptosis (TACIMA)-218. demonstrate that this molecule engenders apoptotic cell death in genetically diverse murine and human cancer lines, irrespective their p53 status, while sparing normal cells. TACIMA-218 causes oxidative stress absence protective antioxidants normally induced by Nuclear factor erythroid 2-related 2 activation. As...
Abstract Objective Estrogen-related-receptor α (ERRα) plays a critical role in the transcriptional regulation of cellular bioenergetics and metabolism, perturbations its activity have been associated with metabolic diseases. While several coactivators corepressors ERRα identified to date, knowledge gap remains understanding extent which cooperates coregulators control gene expression. Herein, we mapped primary chromatin-bound interactome mouse liver. Methods RIME (Rapid Immuno-precipitation...
Dendritic cells (DCs) excel at cross-presenting antigens, but their effectiveness as cancer vaccine is limited. Here, we describe an innovative approach using mesenchymal stromal (MSCs) engineered to express the immunoproteasome (IPr) complex (MSC-IPr). Such modification instilled efficient antigen abilities associated with enhanced major histocompatibility (MHC)I and CD80 expression, de novo expression of interleukin-12 along higher chemokine secretion. In addition, cross-presentation...
<div>Abstract<p>We report the discovery, via a unique high-throughput screening strategy, of novel bioactive anticancer compound: <u>T</u>hiol <u>A</u>lkylating <u>C</u>ompound <u>I</u>nducing <u>M</u>assive <u>A</u>poptosis (TACIMA)-218. We demonstrate that this molecule engenders apoptotic cell death in genetically diverse murine and human cancer lines, irrespective their p53 status, while sparing normal...
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<div>Abstract<p>We report the discovery, via a unique high-throughput screening strategy, of novel bioactive anticancer compound: <u>T</u>hiol <u>A</u>lkylating <u>C</u>ompound <u>I</u>nducing <u>M</u>assive <u>A</u>poptosis (TACIMA)-218. We demonstrate that this molecule engenders apoptotic cell death in genetically diverse murine and human cancer lines, irrespective their p53 status, while sparing normal...