A5102707340- Epigenetics and DNA Methylation
- Advanced Chemical Sensor Technologies
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Genetics and Neurodevelopmental Disorders
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Infant Health and Development
- Child and Adolescent Psychosocial and Emotional Development
- Optical Imaging and Spectroscopy Techniques
- Neurobiology and Insect Physiology Research
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
Tohoku University
2017-2021
Saarland University
2017-2021
Article5 January 2021Open Access Transparent process Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF Kaichi Yoshizaki orcid.org/0000-0002-2540-332X Department of Developmental Neuroscience, Tohoku University Graduate School Medicine, Sendai, Japan Disease Model, Aichi Disability Center, Aichi, Search for more papers by this author Ryuichi Kimura orcid.org/0000-0002-1090-7162 Drug Discovery Kyoto Kyoto, Hisato Kobayashi orcid.org/0000-0003-3800-4691 NODAI Genome...
Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly gaining widespread recognition investigations of transient receptor potential canonical (TRPC) channels. This protocol describes the use three photoswitchable diacylglycerol analogs—PhoDAG-1, PhoDAG-3, OptoDArG—for ultrarapid activation deactivation native TRPC2 channels in mouse vomeronasal sensory neurons olfactory type B cells, as well heterologously expressed human TRPC6 Photoconversion can be...
The understanding of individual diversity and its link to brain functions is a fundamental issue in neurobiology. Studies mice have mainly focused on the investigation behavior traits adulthood, whereas longitudinal analyses are largely uninvestigated. Here we conducted systematic tests (C57BL6/J, male), comparing phenotypes at early postnatal stages adulthood. Each animal showed different scores tests. However, observed an inverse correlation between repetitive Morris water maze test...
Abstract Advanced paternal age has deleterious effects on mental health of next generation. Using a mouse model, we have confirmed that offspring derived from aged fathers showed impairments in behavior and abnormalities the brain structure activity. Comprehensive target DNA methylome analyses revealed sperm more hypo-methylated genomic regions, which REST/NRSF binding motif was enriched. Gene set enrichment also identified “REST/NRSF genes”, addition to “Late-fetal genes” autism spectrum...