Introduction Diquat-related acute kidney injury is well-known. However, neurological disorders caused by diquat are often underestimated, and changes in the imaging findings rarely reported. We present three cases of poisoning resulting toxic encephalopathy.Case report In first case, a 20-year-old previously healthy man ingested approximately 80–100 mL diquat. He developed renal failure, disorders, respiratory failure. Central pontine myelinolysis was considered magnetic resonance (MRI), 18...

Objective: To establish the model of acute kidney injury (AKI), search for more sensitive and reliable biomarkers. Methods: In April 2018, 100 male Wister rats aged 6 to 8 weeks were selected randomly divided into experimental group (n=90) control (n=10). The was given Diachalefin (140 mg/kg body weight) by intragastric administration, while saline administration. Ten in killed 0.5 h, 2 24 3 d, 7 14 21 d 28 after respectively. Serum creatinine (Cr), urea nitrogen (BUN) uric acid (UA)...

Methemoglobinemia can be inherited or acquired. Acquired forms are more common due to drugs poisonous substances that oxidize hemoglobin, and pesticide-related cases notably rare. We report a 69-year-old woman who ingested 30 mL of tebufenozide indoxacarb was asymptomatic for 3 h; however, the patient admitted hospital after 8 h, unconscious, with tachypnea, cyanosis, 61.9% methemoglobin. The administered methylene blue, mechanically ventilated, hemoperfused. Subsequently, recovered...

Acute pesticide poisoning is a major public health concern. The relationship between family function and depression in caregivers of patients with acute unclear. Therefore, this study aimed to explore the function, coping style, among provide theoretical basis intervention targets for future research. A cross-sectional was conducted Department Toxicology Occupational Disease Grade hospital Jinan, Shandong Province, from November 2022 June 2023. general data questionnaire, caring index scale,...

In the present study, successful management of severe paraquat (PQ) poisoning with multiple organ dysfunction syndrome is described. A 42-year-old female ingested >100 ml PQ (20% weight/volume) in an attempted suicide. After 22 h patient was admitted to hospital serious liver, kidney and lung damage. Comprehensive therapy that maximized poison elimination administered, along appropriate glucocorticoids medication for anticoagulation protection liver kidney. The successfully treated recovered...

Diquat (1,1'-ethylene-2,2'-bipyridylium) is a type of widely used agricultural chemical, whose toxicity results in damage to numerous tissues, including the lung, liver, kidney and brain. The aim present study was establish rat model acute diquat exposure explore relationship between concentration, lung injury, order provide an experimental basis for clinical treatment. A total 140 healthy adult male Wistar rats were randomly divided into control groups. solution administered...

Diquat is a herbicide that can have deleterious effects on the kidneys, liver, heart, lungs, and central nervous system ingestion. poisoning-associated rhabdomyolysis has rarely been reported. We describe two cases of diquat poisoning with acute renal failure, myocardial damage, rhabdomyolysis. Case 1: A 17-year-old man experienced anuria after ingesting ~200 mL 16 h prior. On admission, his creatinine (400 μmol/L), urea (11.7 mmol/L), creatine kinase (2,534 IU/L), myohemoglobin (4,425...

Diquat (DQ), chemically known as 1,1 ‘-ethylene-2,2’ -bipyridine, is a non-selective herbicide for leaf removal and drying. It has toxic effects on central nervous system cells, neurological lesions include axonal degeneration pontine myelolysis. At the same time, DQ can also affect activity of dopaminergic nerve cells through oxidative stress, causing reducing dopamine uptake. With increasing application in agricultural production, clinical reports neurotoxicity caused by acute poisoning...

To preliminarily explore, whether glucocorticoids have a therapeutic effect on diquat-induced acute kidney injury in rats.150 Wistar rats were randomly divided into six groups: exposure model group (DQ group), dexamethasone control (GC blank (Ctrl 2.1 mg/kg dose (DQ+L-GC 4.2 (DQ+M-GC and 8.4 (DQ+H-GC with 25 each group. Each was further five subgroups, 24 h, 3 d, 7 14 21 d after exposure, according to the feeding time course of treatment, animals subgroup. The DQ, DQ+L-GC, DQ+M-GC, DQ+H-GC...

Suicidal poisoning by ingestion of organophosphate (OP) insecticides represents a serious emergency with high mortality rate. However, attempted suicide via the parenteral route has rarely been reported. The present study reports case parasuicide self-injection an organophosphorus insecticide (phoxim, phenylglyoxylonitrile oxime O,O-diethyl phosphorothioate) into distal region left arm. patient developed necrosis at injection site and abscess affected limb following injection. A fasciotomy...

Introduction Tralopyril is a metabolite of the pesticide chlorfenapyr. Direct toxicity by tralopyril has not been described. We report two cases poisoning via inhalation.

Severe diquat poisoning often leads to acute kidney injury, gastrointestinal paralytic ileus, rhabdomyolysis, respiratory failure, refractory circulatory and brainstem damage.

Paraquat (methyl viologen, PQ) is highly toxic to humans. Pulmonary fibrosis the most common cause of death after PQ poisoning. However, no effective therapy available. The current treatment dilemma and pathology suggest that we should reconsider how treat poisoning using other methods, such as immunization. Some clues indicate immune mechanisms may play important roles in We implemented a simple experiment test hypothesis activated innate immunity was involved acute lung injury induced by...

In China, and other Asian countries, numerous patients have succumbed to pulmonary fibrosis induced by paquarat poisoning, but the early pathogenesis remains unclear. this study effect of cytokine transforming growth factor (TGF)-β1 was observed in acute paraquat poisoning examined mechanism which caused lung injury. It discovered that rat serum TGF-β1 levels groups were significant higher than control group (P<0.05) mRNA expression also (P<0.05). Histological examination indicated tissue...

Aluminum phosphide is a highly effective insecticide for fumigation in granaries and often used rural grain storage. However, people’s awareness of its toxicity not strong. A case acute inhalation phosphine caused by the use aluminum to fumigate granary reported here. The presented with aspiration pneumonia left heart failure. patient was cured using comprehensive life support treatment, including respiratory support, antiarrhythmic blood pressure maintenance vasoactive drugs. There no...

To analyze the clinical characteristics and therapeutic effects of transoral paraquat poisoning combined with Esophagitis dissecans superficialis (EDS). A retrospective observational study was conducted on patients between January 1, 2011 August 30, 2016 in Qilu hospital. Fifteen EDS were enrolled this study. The characteristics, prognosis, pathological features esophageal necrosis mucosa these retrospectively analyzed summarized. Esophageal mucosal dissection occurs mainly within 3-8 days...

Objective To elucidate the molecular mechanisms by which safflower yellow (SY) mediates therapeutic effects in rats with paraquat intoxication-induced pulmonary fibrosis. Methods Rats received combinations of paraquat, SY, and SB431542, a transforming growth factor (TGF)-β1 receptor antagonist. Survival over 28 days was assessed Kaplan–Meier analysis. Rat tissue serum samples were hematoxylin eosin staining, Masson’s Trichrome immunoblotting, quantitative polymerase chain reaction,...

Abstract Rationale: Despite the fact that treatment of paraquat poisoning in pregnant women and their fetuses is challenging raises ethical issues, it rarely reported literature. We report case a woman who took intentionally. Patient concerns: A 36-year-old at 38 + weeks gestational age, an apparent suicide attempt, drank 1 mouthful (about 20 ml) solution. Ten hours later, her urine dithionate test showed light blue color with plasma concentration 0.547 μg/ml. Six after admission, male...

Olanzapine is a widely adopted atypical antipsychotic medication used to manage schizophrenia. Reports show that the incidence rate of adverse reactions olanzapine significantly lower than those other classic medications. However, overdose may be associated with severe consequences. Herein, we report 21-year-old female patient who had taken nearly 700 mg (70 tablets) olanzapine; she was found after 30 hours. As her condition progressed, presented rhabdomyolysis, swelling in thighs and hips,...

Paraquat (PQ) is a highly toxic herbicide, which not only leads to acute organ damage, but also variety of complications. Patients with severe PQ-induced poisoning may succumb multiple failure involving the circulatory and respiratory systems. Although numerous studies have been performed investigating PQ poisoning, cases extreme bradycardia caused by are rare. In present case report, 59-year-old male who ingested was admitted Department Poisoning Occupational Disease at Qilu Hospital...

Objective In January 2023, a rare event of collective inhalation paraquat poisoning occurred in Shandong, China. To analyze the clinical characteristics an respiratory tract through inhalation. Methods Clinical data from eight patients with were retrospectively analyzed. Results The mainly exposed to via tract. main manifestations ocular and irritation. Lung computed tomography (CT) showed that all had varying degrees lung injury, manifesting as exudative lesions. Laboratory tests revealed...

Acute organophosphorus pesticide poisoning (AOPP) with cardiac arrest has an extremely high mortality rate, and corresponding therapeutic strategies have rarely been reported. Therefore, this study aimed to explore the prognostic factors effective treatments of AOPP-related arrest. This retrospective was conducted in our department years 2018–2021. We a descriptive analysis clinical manifestations, rescue strategies, prognosis patients AOPP who had experienced successful cardiopulmonary...