A5052708908- Antiplatelet Therapy and Cardiovascular Diseases
- Adenosine and Purinergic Signaling
- Forest Insect Ecology and Management
- Forest Ecology and Biodiversity Studies
- Inflammatory mediators and NSAID effects
- Hepatitis C virus research
- Atrial Fibrillation Management and Outcomes
- Hepatitis B Virus Studies
- Synthesis of β-Lactam Compounds
- Eicosanoids and Hypertension Pharmacology
- Biochemical and Molecular Research
- Acute Myocardial Infarction Research
- Ion channel regulation and function
- Analytical Methods in Pharmaceuticals
- RNA modifications and cancer
- HIV/AIDS Research and Interventions
- Pharmacology and Obesity Treatment
- Opioid Use Disorder Treatment
- Receptor Mechanisms and Signaling
- Cardiovascular Issues in Pregnancy
- Dysphagia Assessment and Management
- Cannabis and Cannabinoid Research
- Adolescent and Pediatric Healthcare
- Pain Mechanisms and Treatments
- Bipolar Disorder and Treatment
University of Florida
2016-2024
Florida State Collection of Arthropods
2024
Florida Department of Agriculture and Consumer Services
2024
Vanderbilt University Medical Center
2022-2023
Emory University Hospital
2021
University of Nottingham
2005-2018
Queen's Medical Centre
2006-2018
University School
2017
Indiana University
2017
Indiana University – Purdue University Indianapolis
2009-2016
Receptors for prostanoids on platelets include the EP3 receptor which natural agonist is inflammatory mediator prostaglandin E(2) (PGE(2)) produced in atherosclerotic plaques. implicated atherothrombosis and an antagonist might provide lesion-specific antithrombotic therapy. DG-041 (2,3-dichlorothiophene-5-sulfonic acid, 3-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]acryloylamide) a direct-acting currently being evaluated Phase 2 clinical trials. We have examined contributions of...
The effects of prostaglandin E(2) (PGE(2)) on platelet function are believed to be the result opposing mechanisms that lead both enhancement and inhibition function. Enhancement is known via EP3 receptors linked G(i) adenylyl cyclase. However, involved in have not been fully defined. Here we used measurements aggregation, calcium signaling P-selectin expression assess induced by activating factor (PAF), thrombin receptor peptide (TRAP-6) thromboxane A(2) mimetic U46619 respectively,...
The aim of this study was to determine the prevalence sleep-related breathing disorders (SDB) in a UK general heart failure (HF) population, and assess its impact on neurohumoral markers symptoms sleepiness quality life. Eighty-four ambulatory patients (72 male, mean (SD) age 68.6 (10) yrs) attending HF clinics underwent an overnight recording respiratory impedance, SaO2 rate using portable monitor (Nexan). Brain natriuretic peptide (BNP) urinary catecholamines were measured. Subjective...
Abstract Background Antiretroviral therapy (ART) has reduced mortality among people living with HIV (PLWH) in China, but co-infections of hepatitis B virus (HBV) and C (HCV) may individually or jointly reduce the effect ART. This study aimed to evaluate impacts HBV/HCV coinfections on treatment drop-out PLWH Methods A retrospective cohort analysis 58 239 who initiated antiretroviral during 2010–2018 was conducted Guangxi Province, China. Data were from observational database National Free...
EP3 receptor antagonists may provide a new approach to the treatment of atherothrombotic disease by blocking ability prostaglandin E2 (PGE2) promote platelet function acting via receptors. DG-041 is an antagonist in early stage clinical development. Here, we quantitated effects on in-vitro and ex-vivo after administration man when given alone concomitantly with clopidogrel or aspirin. With its unique mechanism action, it was anticipated that would potentiate inhibition combination without...
There is wide variation in response to antiplatelet therapy and high on-treatment platelet reactivity associated with adverse cardiovascular events. The objective here was determine whether the results of a novel strategy for assessing (based on P-selectin measurement) are clinical outcomes patients acute coronary syndromes (ACS). This prospective cohort study 100 ACS taking aspirin clopidogrel. tests designed assess P2Y12 antagonists or were performed alongside light transmission...
Summary mRNA encoding the recently discovered P2Y14 receptor has been reported in platelets, but presence of protein and its functionality have not studied. If is expressed along with P2Y1 P2Y12 receptors it may a role haemostasis. It was objective this study to investigate platelets platelet function. The effects agonist UDP-glucose were compared those sulprostone, selective EP3 agonist. Expression investigated by immunoblotting confocal microscopy. Platelet aggregation platelet-rich plasma...
Summary Cost, time, and expertise constraints limit traditional observation-based comprehensive biodiversity assessment. Therefore, surrogate focal taxa representative of wider are commonly used as an imperfect ‘proxy’. Contemporary assessments also increasingly benefiting from the combination high-throughput sequencing metagenomic methodologies that enable identification environmental DNA samples. However, there is a need for empirical studies combining use with approaches, promise rapid...
Exotic diseases and pests of trees have caused continental-scale disturbances in forest ecosystems industries, their invasions are considered largely unpredictable. We tested the concept preinvasion assessment not yet invasive organisms, which enables empirical risk potential invasion impact. Our example assesses fungi associated with Old World bark ambrosia beetles to impact North American trees. selected 55 Asian European scolytine beetle species using host use, economic, regulatory...
AbstractADP induces platelet aggregation in human whole blood and platelet-rich plasma (PRP). ATP only; this involves leukocytes is mediated by ADP. Here we studied ATP- ADP-induced patients with raised leukocyte counts (mean 46.2 × 103 leukocytes/µl). Platelet was measured counting. ATP, ADP metabolites were HPLC. Aggregation to (1–10 µM) (10–100 markedly reduced, but (1000 enhanced (all p < 0.001). PRP normal. Increasing the count normal reproduced findings patients. Adding (either MNLs or...
Measurement of P-selectin on activated platelets as a means measuring platelet function utilizing the technology described here has advantage not requiring immediate access to specialist equipment and expertise. Blood samples are activated, fixed, stored, transported central laboratory for flow cytometric analysis. Here we have compared with other more traditional approaches in blood and/or platelet-rich plasma (PRP) from patients acute coronary syndromes treatment at least 1 month either...
Abstract This study investigated the relationship between genetic and morphological evidence in a species complex of haplodiploid, near-inbred ambrosia beetles, which are also vectors an invasive tree pathogen: Xyleborus ferrugineus, bispinatus , impressus . The unorthodox system may blur boundaries challenges applicability standard concepts. Haplo-diploid scolytine systematics is rife with contentious delimitation, but limits have rarely been tested empirically. To test congruence...
Introduction The objective of this study was to describe the implementation and outcomes a protocol outlining angiotensin-II utilization for vasoplegia following cardiac surgery. Methods This retrospective chart review at single-center university hospital. Included patients received refractory standard interventions, including norepinephrine 20 mcg/min vasopressin 0.04 units/min, surgery between April 2021 2022. Results 30 vasoplegia. Adjunctive agents initiation included corticosteroids (26...
We observed previously that the extent of ADP-induced platelet aggregation in blood from patients with leucocytosis is markedly reduced. obtained evidence this via enhanced ADP metabolism consequent to high leucocyte count, and speculated ecto-NTPDase CD39 on leucocytes may be involved. Here we have investigated association between aggregation, expression leucocytosis. Six were compared six normal controls. Platelet was measured using counting. analysed by HPLC. each volunteer patient flow...
Protease-antiprotease imbalance in the lung is considered a likely pathogenetic mechanism development of emphysema. To assess whether differences enzyme release from stimulated neutrophils could be factor leading to increased elastase lung, we compared vitro and lysosomal enzyme, β-glucosaminidase, nonsmokers smokers. Neutrophils were by zymosan as phagocytic stimulus, synthetic polypeptide, N-formyl-methionyl-leucyl-phenyl-alanine (FMLP) chemotactic factor. We studied 54 male subjects, 24...