A5091175545- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- SARS-CoV-2 and COVID-19 Research
- Seed and Plant Biochemistry
- Food composition and properties
- Gut microbiota and health
- Antimicrobial Peptides and Activities
- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- Enzyme Production and Characterization
- Aquaculture disease management and microbiota
- Amino Acid Enzymes and Metabolism
- Enzyme Catalysis and Immobilization
- Listeria monocytogenes in Food Safety
- Polyamine Metabolism and Applications
- Long-Term Effects of COVID-19
- Proteins in Food Systems
- Clostridium difficile and Clostridium perfringens research
- Alzheimer's disease research and treatments
- Click Chemistry and Applications
- International Environmental Law and Policies
- Peripheral Neuropathies and Disorders
- Influenza Virus Research Studies
- Urinary Tract Infections Management
- Biotin and Related Studies
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2024
National University of Tucumán
2009-2024
Ministerio de Salud
2024
Instituto Superior de Investigaciones Biológicas
2016-2017
Accademia Albertina delle Belle Arti
2016
Universidade de São Paulo
2012
Centro Científico Tecnológico - Tucumán
2012
To analyse lactic acid bacteria (LAB) diversity and technological‐functional safety properties of strains present during spontaneous fermented quinoa sourdoughs. Fermentation was performed by daily backslopping at 30°C for 10 days. Autochthonous LAB microbiota monitored a biphasic approach combining random amplified polymorphic DNA (RAPD)‐PCR rRNA gene sequencing with PCR‐denaturing gradient gel electrophoresis (DGGE) analysis. Identification intraspecies differentiation allowed to group...
Gam-COVID-Vac (SPUTNIK V) has been granted emergency use authorization in 70 nations and administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. Independent reports regarding safety effectiveness could accelerate the final approval by WHO. We aimed study long-term humoral immune response naïve previously infected volunteers who received SPUTNIK V.Humoral responses, assayed anti-SARS-CoV-2-spike-RBD IgG ELISA neutralization assays, were...
Spontaneous fermented sourdoughs prepared from amaranth flour were investigated for the presence of autochthonous lactic acid bacteria (LAB) predominating microbiota. The doughs with daily backslopping on a laboratory scale at 30°C 10 days. LAB counts ranged 2·60 to 8·54 log CFU g(-1) pH declined 6·2 3·8 throughout fermentation. combined use randomly amplified polymorphic DNA (RAPD)-PCR analysis and sequence 16S rRNA was applied intraspecies differentiation taxonomic identification,...
The aim of this study was to analyze the influence vitamins, glycerol, and salts on growth bacteriocin production by Lactobacillus salivarius CRL 1328, a human vagina isolate, using chemically defined medium determine optimal conditions for salivaricin production. single omission <span class="smallcap">d</span>-biotin, thiamine, p-aminobenzoic acid, folic or cyanocobalamin did not affect bacterial growth, whereas removal nicotinic riboflavin, pyridoxal produced decrease about 30% in rate....
Abstract We hypothesized that in individuals with previous SARS-CoV-2 infection, the first vaccine dose would work as a booster, eliciting faster and more intense immune response. herein describe antibody responses to second doses of Gam-COVID-Vac (SPUTNIK V) health personnel Tucumán, Argentina, COVID-19 compared it uninfected personnel. Individuals anti-SARS-CoV-2 titers at baseline showed significantly higher than people no prior history disease (p <0.0001), those registered after...
Vaginal lactobacilli (LAB) in probiotic formulas constitute a promising alternative for microbiome reconstitution and the prevention treatment of urogenital infections. A double-blind, randomised clinical trial was conducted to assess safety LAB-gelatine capsules vaginally administered healthy sexually active women. Participants were into three groups: intervention A: Lactobacillus reuteri CRL1324, gasseri CRL1263 CRL1307; B: rhamnosus CRL1332, L. CRL1256 CRL1320; C: placebo. In survey...
Bacteriocins are antimicrobial peptides with potential applications as therapeutic agents for the treatment of microbial infections. The aim this work was to investigate effect different protectors on activity salivaricin CRL1328, a bacteriocin produced by Lactobacillus salivarius during lyophilization process and subsequent storage at temperatures 18 months using statistical models. Different such mannitol, Tween 80, polyethylene glycol 8000 (PEG), monosodium glutamate (MSG), reconstituted...
The administration of pharmabiotics is a promising alternative to antimicrobial drugs for the treatment and/or prevention female urogenital infections.To design pharmabiotic formulations including bioactive ingredients microbial origin combined with non-microbial substances and then evaluate stability combinations during freeze-drying storage.Different Lactobacillus gasseri CRL 1263, salivarius 1328, salivaricin 1328 (a bacteriocin) compounds (lactose, inulin ascorbic acid) were assayed,...
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic with dramatic health and socioeconomic consequences. Coronavirus Disease 2019 (COVID-19) challenges systems to quickly respond by developing new diagnostic strategies that contribute identify infected individuals, monitor infections, perform contact-tracing, limit the spread of virus. In this brief report, we developed highly sensitive, specific, precise "In-House" ELISA correctly discriminate...
The early sequencing of the SARS-CoV-2 viral genome allowed for a speedy development effective vaccines against virus. Nevertheless, age-related immunosenescence, inability to mount strong immune responses, still represents major obstacle. Here, in group 149 elderly volunteers (70-96 years old), evolution humoral response over time Gam-COVID-Vac (Sputnik V), vaccine based on heterologous recombinant adenovirus-26 (Ad26) and adenovirus-5 (Ad5) carrying Spike genome, was analyzed by an...
The escalating prevalence of Parkinson's disease (PD) underscores the need for innovative therapeutic interventions since current palliative measures, including standard l-Dopa formulations, face challenges tolerance and side effects while failing to address underlying neurodegenerative processes. Here, we introduce DAD9, a novel conjugate molecule that aims combine symptomatic relief with disease-modifying strategies PD. Crafted through knowledge-guided chemistry, combines nonantibiotic...
Background: Gam-COVID-Vac, also known as SPUTNIK V, is the first COVID-19 vaccine registered, has emergency use authorization in 70 nations, and been administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. As independent reports begin be published, a more accurate picture regarding safety effectiveness could accelerate approval by WHO.Methods: An ELISA that detects anti-SARS-CoV-2-spike-RBD IgG was used, both transversal longitudinal...