A5000081491- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Graphene research and applications
- MRI in cancer diagnosis
- Advancements in Transdermal Drug Delivery
- Medical Imaging Techniques and Applications
- Ocular Surface and Contact Lens
- Carbon and Quantum Dots Applications
- Lipid Membrane Structure and Behavior
- Dermatology and Skin Diseases
- Optical Coherence Tomography Applications
- Electrical and Bioimpedance Tomography
- Nanomaterials and Printing Technologies
- Advanced NMR Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
Stanford University
2024-2025
Northwestern University
2012-2016
The delivery of bioactive molecules into cells has broad applications in biology and medicine. Polymer-modified graphene oxide (GO) recently emerged as a de facto noncovalent vehicle for hydrophobic drugs. Here, we investigate different approach using native GO to deliver hydrophilic by co-incubation culture. adsorption were systematically studied with library 15 synthesized Gd(III) labels enable quantitation. Amines revealed be key chemical group adsorption, while was shown quantitatively...
Abstract Using high‐resolution 3D printing, a novel class of microneedle array patches (MAPs) is introduced, called latticed MAPs (L‐MAPs). Unlike most which are composed either solid structures or hollow needles, L‐MAPs incorporate tapered struts that form cells capable trapping liquid droplets. The lattice can also be coated with traditional viscous coating formulations, enabling both liquid‐ and solid‐state cargo delivery, on single patch. Here, library 43 L‐MAP designs generated...
Dermal interstitial fluid (ISF) offers a promising alternative to invasive blood tests and opportunities for novel skin diagnostics. Progress in both the understanding adoption of ISF is hindered by sampling challenges, including lengthy collection times, non-negligible failure rates, variable volumes, inconsistent bioanalyte levels. The causes many these issues are not well understood. We demonstrate microneedle device that several times faster than state-of-the-art, collecting an average...
ADVERTISEMENT RETURN TO ISSUEPREVFeatureNEXTAnalytical Methods for Characterizing Magnetic Resonance ProbesThe efficiency of Gd(III) contrast agents in magnetic resonance image enhancement is governed by a set tunable structural parameters. Understanding and measuring these parameters requires specific analytical techniques. This Feature describes strategies to optimize each the critical relaxation molecular imaging applications methods employed their evaluation.Lisa M. Manus, Renee C....
Gd(III) associated with carbon nanomaterials relaxes water proton spins at an effectiveness that approaches or exceeds the theoretical limit for a single bound molecule. These Gd(III)-labeled materials represent potential breakthrough in sensitivity Gd(III)-based contrast agents used magnetic resonance imaging (MRI). However, their mechanism of action remains unclear. A gadographene library encompassing GdCl
Cell tracking in vivo with MR imaging requires the development of contrast agents increased sensitivity that effectively label and are retained by cells. Most clinically approved Gd(III)-based require high incubation concentrations prolonged times for cellular internalization. Strategies to increase agent permeability have included conjugating Gd(III) complexes cell penetrating peptides, nanoparticles, small molecules which greatly improved labeling but not resulted retention. To overcome...
Purpose To demonstrate a new MR imaging approach that unambiguously identifies and quantitates contrast agents based on intrinsic agent properties such as r 1 , 2 magnetic susceptibility. The is referred to barcode (MBI). Methods Targeted bioresponsive were imaged in agarose phantoms generate T quantitative susceptibility maps. parameter maps processed by machine learning algorithm trained recognize the these parameters. output map of concentration, identity, functional state. Results MBI...
Purpose To minimize feature loss in T1- and T2-weighted MRI by merging multiple MR images acquired at different TR TE to generate an image with increased dynamic range. Materials Methods High Dynamic Range (HDR) processing techniques from the field of photography were applied a series images. Specifically, method parameterize algorithm for data was developed tested. number contrast agent phantoms live mouse varying parameters. The computationally merged produce HDR-MR All acquisitions...