Fibrillin-containing microfibrils in elastic and nonelastic extracellular matrices play important structural functional roles various tissues, including blood vessels, lung, skin, bone. Microfibrils are supramolecular aggregates of several protein nonprotein components. Recently, a large region the N-terminal portion fibrillin-1 was characterized as multifunctional interaction site, binding sites for fibulin-2 -5 among others. Using panel recombinant swapped domain deletion fragments, we...

Microfibrils are essential elements in elastic and nonelastic tissues contributing to homeostasis growth factor regulation. Fibrillins form the core of these multicomponent assemblies. Various human genetic disorders, fibrillinopathies, arise from mutations fibrillins frequently associated with aberrant microfibril assembly. These disorders include Marfan syndrome, Weill-Marchesani Beals others. Although homotypic heterotypic fibrillin self-interactions considered provide critical initial...

Alternaria species, mainly air-borne fungi, affect potato plants, causing black spots symptoms. Morphological identification, pathogenicity assessment, and internal transcribed spacer (ITS) molecular identification confirmed that all isolates were alternata. The annotated sequences deposited in GenBank under accession numbers MN592771–MN592777. HPLC analysis revealed the fungal KH3 (133,200 ng/g) NO3 (212,000 produced higher levels of tenuazonic acid (TeA) alternariol monomethyl ether (AME),...

Under sandy soil conditions, increasing the efficiency of potassium (K) fertilizers is considered to be a major limiting factor for improving productivity and quality fruit crops. In this context, utilizing nanotechnology has emerged as novel technique increase K applications. our study, two field trials were conducted, in consecutive seasons (2019/2020 2020/2021), compare effects nano-chitosan loaded with foliar treatment those conventional applications on plant growth, yield, strawberry...

Mutations in fibrillin-1 lead to Marfan syndrome and some related genetic disorders. Many of the more than 600 mutations currently known eliminate or introduce cysteine residues epidermal growth factor-like modules. Here we report structural functional consequences three selected (R627C, C750G, C926R) fibrillin-1. The have been analyzed by means recombinant polypeptides produced mammalian expression systems. mRNA levels for mutation constructs were similar wild-type levels. All mutated...

Tobacco mosaic virus (TMV) causes severe damage and economic losses of tomato in crop yield production quality worldwide. Tomato plants infected with TMV usually show a pattern chlorosis symptoms that result from affected chloroplasts. To elucidate tomato–TMV interactions, the transcriptional profiles tissues at different time intervals were analysed using differential display-polymerase chain reaction technique. Compared to mock-inoculated plants, based on gene expression changes...

Cropping systems in the Level Barind Tract (LBT) of Bangladesh are highly diverse, as Transplanted (T.) Aman and Boro (T. Boro) rice a common practice area. Although. T. is generally cultivated rainy (monsoon) season, but intensive irrigation-based winter with high establishment costs result exhaustive tillage labours for transplanting seedlings. Furthermore, pumping large amount irrigation during cultivation declines level groundwater, which not environmentally friendly nor cost-effective....

Drought stress is one of the limiting factors for grain filling and yield in wheat. The determinants individual weight depend on current assimilation extent remobilization culm reserves to grains. A pot experiment was conducted with eight wheat cultivars at Pot House study contributions culm, including sheath under drought stress. enforced by restricting irrigation during grain-filling period. plants (tillers) were harvested anthesis, milk-ripe, maturity. changes dry weights leaves, sheath,...

Diabetes mellitus (DM) is one of the most serious threats in 21th century throughout human population that needs to be addressed cautiously. Nowadays, stem cell injection considered among promising protocols for DM therapy; owing its marked tissues and organs repair capability. Therefore, our 4 weeks study was undertaken elucidate probable beneficial effects two types adult mesenchymal cells (MSCs) on metabolism disturbance some tissue function defects diabetic rats. Animals were classified...

Abstract Autoantibodies against short recombinant fragments of fibrillin-1 produced in bacterial expression systems have been found tight-skin mouse, systemic sclerosis, mixed connective tissue disease, and primary pulmonary hypertension syndrome. In patients with scleroderma, the frequency anti-fibrillin-1 antibodies was 42% Caucasians. Until now it has unclear whether this immune response a function disease pathogenesis or is secondary phenomenon. present study we analyzed autoantibodies...

The thermal environment of a crop is one the prime factors enhancing growth and production by regulating its physiological processes at different phenophases. To study impact regime on spring–summer-grown black gram (variety Pant Urd 31), an experiment was conducted with sowing dates (from first to third week March), soil application cobalt (Co) foliar sprays potassium (K) boron (B) in various combinations split–split plot design during 2020 2021. first-week-of-March-sown recorded more...

Mesenchymal stem cells-derived exosomes (MSCs-EXs) applications have brought a key breakthrough in treating type 1 diabetes mellitus (T1DM) and its diabetic complications. However, various recent strategies aimed to construct prominent engineered EXs with greater precision higher efficiency for syndrome were conducted. In this research, we seek enhance the medicinal potentialities of MSCs-EXs on rats' hepatic complications, via loading either selenium (Se) or nano (NSe) particles. For...

Purpose Short stature affects approximately 2%–3% of children, representing one the most frequent disorders for which clinical attention is sought during childhood. Despite assumed genetic heterogeneity, mutations or deletions in short homeobox-containing gene (SHOX) are frequently detected subjects with stature. Idiopathic (ISS) refers to patients various unknown reasons. The goal this study was screen all exons SHOX identify related mutations. Methods We screened analysis 105 ISS children...

Radiation exposure can cause several harmful effects in biological systems due to free radical production. Several antioxidants have been tested as potential hepatoprotective agents against ionizing radiation they lower oxidative stress normal cells induced by Reactive Oxygen Species (ROS). The present study was conducted evaluate the possible ameliorative of Juniperus phoenicea L.Aqueous leaves extract on different biochemical and histopathological parameters whole body...

Diabetes mellitus (DM) could negatively affect patients' health via inducing a lot of serious functional hazards in many tissues' cells at molecular levels. Recently, scientists had proposed stem cell therapy being an appropriate alternative treatment protocol for numerous threatening issues including diabetes. Therefore, the current study was designed to investigate antioxidant potentiality two MSCs types alleviating oxidative stress dramatic elevation resulting as consequence Type 1 DM...

Surfactant effects on the drug release from controlled systems have been widely studied. These are dependent surfactant physical properties such as structure, charge, solubility and concentration. In addition, presence of excipients in matrices can modify surfactants effects. Here we investigated concentration release. Two cationic (cetrimide cetylpyridinium chloride), two anionic (sodium lauryl sulfate sodium taurcholate) amphoteric betaine were used. The used dissolution medium was...

Mesenchymal stem cells (MSCs) are considered to be a promising therapeutic protocol for diabetes mellitus (DM) management. The latter is attributed their differentiation potentiality pancreatic β-cells, angiogenesis, and immune-modulatory capabilities by releasing various paracrine factors. Interestingly, antioxidant co-administration increased the MSCs’ hypoglycemic regenerative activities. Thus, this study aims evaluate implication of type 1 DM after adipose tissue-derived-MSCs (AD-MSCs)...

Since Type 1 diabetes (T1DM) occurs when β-cells mass is reduced to less than 20% of the normal level due autoimmune destruction cells resulting in inability secrete insulin, preservation or replenishment functional has become a major therapeutic focus for this diabetic type treatment. Thus, 4-week work plan was designed determine which mesenchymal stem (MSCs) more appropriate alleviate pancreatic hazards from induction; via tracking comparative study between MSCs derived adipose tissue...

Background and Objective: Nephrotic syndrome (NS) is the most well-known glomerular kidney disease in children.Genetic risk highly frequently detected amongst childhood steroid-resistant NS (SRNS) disease.Therefore, aim of present research was to evaluate ACTN4 PLCE1 genes mutations children with SRNS western region Saudi Arabia.Materials Methods: Twenty patients were identified screened for gene within (21 exons) (33 by direct sequencing method elucidate correlation between these...

Diabetic cardiomyopathy (DCM) is considered one of the main diabetic complications, contributing to specific forms heart failure independent from hypertension or ischemia. There are increased research efforts further explore a new potential therapeutic strategy for preventing reversing DCM progression. The present aimed which type stem cell-based therapies could serve as an effective tool treatment in 1 rats. Four groups male Wistar rats have been used this study including control group,...

Controlled release drug formulation is a very important branch in pharmaceutical industry and attracts lot of research investments. Eudragit RL100 sodium carboxymethylcellulose (NaCMC) are used due to their good coating properties. Here, we studied propranolol hydrochloride with anionic polymer alone other additives (lactose, sorbitol, dextrose). The was also RL 100 carboxymethyl cellulose different concentrations surfactants (Sodium lauryl sulfate, Sodium taurcholate, Cetrimide,...