We report on a laser that is fully embedded within single live cell. By harnessing natural endocytosis of the cell, we introduce fluorescent whispering gallery mode (WGM) microresonator into cell cytoplasm. On pumping with nanojoule light pulses, green emission generated inside cells. Our approach can be applied to different types, and cells microresonators remain viable for weeks under standard conditions. The characteristics lasing spectrum provide each barcode-type label which enables...

Organic semiconductors enable the fabrication of a range lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to need for support substrate. Here, we use simple process make membrane-based, substrate-less extremely thin (<500 nm) distributed feedback lasers that offer ultralow-weight (m/A<0.5 gm-2) excellent mechanical flexibility. We show operation as free-standing membranes transfer them...

Nanophotonic objects like plasmonic nanoparticles and colloidal quantum dots can complement the functionality of molecular dyes in biomedical optics. However, their operation is usually governed by spontaneous processes, which results broad spectral features limited signal-to-noise ratio, thus restricting opportunities for multiplexing sensing. Lasers provide ultimate definition background suppression, integration with cells has recently been demonstrated. laser size threshold remain...

Abstract Reliable methods to individually track large numbers of cells in real time are urgently needed advance our understanding important biological processes like cancer metastasis, neuronal network development and wound healing. It has recently been suggested introduce microscopic whispering gallery mode lasers into the cytoplasm use their characteristic, size-dependent emission spectrum as optical barcode but so far there is no evidence that this approach generally applicable. Here, we...

In this work, we successfully demonstrate how imaging ellipsometry can be applied to obtain high-resolution thickness maps of few-layer graphene (FLG) samples, with the results being thoroughly validated in a comparative study using several complementary techniques: Optical reflection microscopy (ORM), atomic force (AFM), and scanning confocal Raman microscopy. The map, revealing distinct terraces separated by steps corresponding mono- bilayers graphene, is extracted from pixel-to-pixel...

We demonstrate an evanescently pumped water-based optofluidic distributed feedback (DFB) laser with a record low pump threshold of ETH=520 nJ. The results from optimized mode shape, which is achieved by refractive index substrate, and the use mixed-order DFB grating. Investigating photonic band structure via angular dispersion analysis both above below lasing allows us to measure liquid gain layer determine device parameters such as waveguide core thickness. show that it possible tailor...

Biological single cell lasers have shown great potential for fundamental research and next generation sensing applications. In this study, the of fluorescent biological cells as refractive index landscapes active optical elements is investigated using a combined Fourier- hyperspectral imaging technique. We show that contrast between surrounding leads to 3D confinement photons inside living cells. The real-space emission characteristics these are closely related can be predicted from one...

Abstract Organic single crystals are of interest for optoelectronic applications due to their highly ordered molecular stacking and small defect concentration, giving the possibility high mobility luminescence efficiency. To achieve lasing in large flat crystals, a simple “pick place” method mounting organic onto distributed feedback gratings is demonstrated. Efficient achieved with three kinds active indicating potential broad application making crystal lasers using gratings. Detailed...

Abstract Fluorescent proteins have emerged as an attractive gain material for lasers, especially devices requiring biocompatibility. However, due to their optical properties, integration with distributed feedback (DFB) resonators is not readily achievable. Here, a DFB laser enhanced green fluorescent protein (eGFP) the demonstrated by incorporating thin (65 nm), high refractive index ( n = 2.12) ZrO 2 interlayer waveguide core. Deposition of via atomic layer deposition yields smooth and...

Direct laser writing of photonic boxes into active layers biologically produced recombinant fluorescent protein in optical microcavities is demonstrated. Irradiation with light above the photobleaching threshold induces confinement potentials on order 40 meV. The technique provides high spatial selectivity and enables room-temperature lasing rings, circular elliptical pillars customized beam shapes. There a rapidly increasing interest photonics research community to develop methods for...

We report on a laser in the form of flexible and lightweight membrane that can be affixed to objects such as banknotes, contact lenses, finger nails. Bendable stretchable solar cells LEDs based carbon-based polymers small molecules are described literature. However, first organic lasers were rigid relatively bulky, part because they use thick stiff support substrate.

In this work, we optimize Bragg gratings covered with SU-8 for TM polarized light at a center wavelength of 1550 nm respect to high reflectivity and large wavelength range employing 3D FDTD simulations. Three different types of lateral grating modulation were studied: I) complete interruption the waveguide, II) corrugation within waveguide width, III) corrugation exceeding width. The wavelength response was analyzed discrete Fourier transformation algorithm Gaussian pulse source....

Optofluidic biolasers are an emerging tool for bio-sensing and diagnostics. However, in order to facilitate waveguiding, the most common optofluidic distributed feedback (DFB) laser design relies on high-refractive index gain materials which usually not biocompatible. We report realization characterization of evanescently pumped DFB lasers with biocompatible aqueous fluids. Record low pump thresholds were achieved by optimizing mode shape waveguide structure. Measuring photonic band...

We report the application of semiconductor nanodisk lasers within living cells. Our have volumes 1000-fold smaller than eukaryotic nuclei, ultralow pulse energy lasing thresholds (Eth≈0.13pJ), and provide excellent spectral stability.