A5103108035- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Lipid Membrane Structure and Behavior
- Neural dynamics and brain function
- Lipoproteins and Cardiovascular Health
- Sperm and Testicular Function
- Pain Mechanisms and Treatments
- Spinal Cord Injury Research
- Musculoskeletal pain and rehabilitation
- RNA Interference and Gene Delivery
- Advanced Fluorescence Microscopy Techniques
- Diabetes Treatment and Management
- Nerve injury and regeneration
- Cytokine Signaling Pathways and Interactions
- Botulinum Toxin and Related Neurological Disorders
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Advanced biosensing and bioanalysis techniques
- Neuropeptides and Animal Physiology
- Cell Image Analysis Techniques
- Reproductive Biology and Fertility
United Arab Emirates University
2023-2025
Witten/Herdecke University
2020-2022
Ruhr University Bochum
2006-2021
Centro Medicina della Riproduzione
2012
Glutamatergic transmission converging on calcium signaling plays a key role in dendritic differentiation. In early development, AMPA receptor (AMPAR) transcripts are extensively spliced and edited to generate subunits that differ their biophysical properties. Whether these have specific roles the context of structural differentiation is unclear. We investigated nine GluA variants revealed correlation between expression flip period major growth. interneurons, only GluA1(Q)-flip increased...
The ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazole propionate glutamate receptors (AMPARs) have been implicated in the establishment of dendritic architecture. transmembrane AMPA receptor regulatory proteins (TARPs) regulate AMPAR function and trafficking into synaptic membranes. In current study, we employ type I II TARPs to modulate expression levels endogenous AMPARs investigate organotypic cultures (OTCs) rat occipital cortex whether this influences neuronal differentiation. Our...
NMDA receptors are important players for neuronal differentiation. We previously reported that antagonizing with APV blocked the growth-promoting effects evoked by overexpression of specific calcium-permeable or flip-spliced AMPA receptor subunits and type I transmembrane regulatory proteins which both exclusively modify apical dendritic length branching cortical pyramidal neurons. These findings led us to characterize role GluN2B GluN2A dendritogenesis using organotypic cultures rat visual...
The function of medial entorhinal cortex layer II (MECII) excitatory neurons has been recently explored. MECII dysfunction underlies deficits in spatial navigation and working memory. comprise two major neuronal populations, pyramidal island stellate ocean cells, addition to the inhibitory interneurons. Ocean cells express reelin surround clusters that lack expression. influence expression by interneurons on their own morphological differentiation remained unknown. To address this, we used a...
Proper growth and branching of dendrites are crucial for adequate central nervous system (CNS) functioning. The neuronal dendritic geometry determines the mode quality information processing. Any defects in dendrite development will disrupt circuit formation, affecting brain function. Besides cell-intrinsic programmes, extrinsic factors regulate various aspects development. Among these extracellular molecular signals which can shape architecture during early This review focus on regulating...
ABSTRACT Reelin is a large secreted glycoprotein that regulates neuronal migration, lamination and establishment of dendritic architecture in the embryonic brain. expression switches postnatally from Cajal-Retzius cells to interneurons. However, reelin function interneuron development still poorly understood. Here, we have investigated role postnatal neocortex. To preclude early cortical migration defects caused by deficiency, employed conditional knockout (RelncKO) mouse induce deficiency....
Reelin is a protein that best known for its role in controlling neuronal layer formation the developing cortex. Here, we studied post-natal cortical network function, which poorly explored. To preclude early migration defects caused by deficiency, used conditional knock-out (RelncKO ) mouse, and induced deficiency post-natally. Induced hyperexcitability of neocortical vitro ex vivo. Blocking binding to receptors ApoER2 VLDLR resulted similar effect. Hyperexcitability RelncKO organotypic...
Abstract Transient transfection of cultured mammalian cells is widely employed in the study ionotropic glutamate receptors. Heteromeric expression usually achieved by simultaneous various combinations receptor subunit‐encoding cDNAs. This approach based on an “all‐or‐none” assumption, rarely verified experimentally, that any given cell expresses all subunits present during transfection. A similar assumption implicitly made when cotransfection a cDNA encoding fluorescent marker protein...
Introduction:In the last decades sperm DNA quality has been recognized as one of most important markers male reproductive potential (Lewis and Aitken, 2005; Ozmen, 2007; Tarozzi, 2007), in contrast to standard semen parameters density, motility morphology, which do not act powerful discriminators between fertile infertile men.DNA damage germ line is a major contributor infertility, miscarriage birth defects offspring.In animal models, it unequivocally demonstrated that genetic integrity...
The 30-amino acid peptide Y-P30 corresponds to the N-terminus of primate-specific, sweat gland-derived dermcidin prepropeptide. Previous work has revealed that enhances interaction pleiotrophin and syndecans-2/3, thus represents a natural ligand study this signaling pathway. In immature neurons, activates c-Src p42/44 ERK kinase pathway, increases amount F-actin in axonal growth cones, promotes neuronal survival, cell migration elongation. action on requires syndecan-3 heparan sulfate side...
Background Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by increased LDL-cholesterol levels. About 85% of FH cases are caused LDLR mutations encoding the low-density lipoprotein receptor (LDLR). synthesized in endoplasmic reticulum (ER) where it undergoes post-translational modifications and then transported through Golgi apparatus to plasma membrane. Over 2900 variants have been reported patients with limited information on pathogenicity functionality...
The role that the immune system plays after injury of peripheral nervous is still not completely understood. Perforin, a natural killer cell- and T-lymphocyte-derived enzyme mediates cytotoxicity, important roles in autoimmune diseases, infections central trauma, such as spinal cord injury. To dissect this single component response to injury, we tested regeneration femoral nerve perforin-deficient (Pfp-/-) wild-type control mice. Single frame motion analysis showed better motor recovery...