A5074734846- Iron Metabolism and Disorders
- Trauma and Emergency Care Studies
- COVID-19 and healthcare impacts
- Erythropoietin and Anemia Treatment
- Colorectal Cancer Surgical Treatments
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- American Environmental and Regional History
- Blood transfusion and management
- American History and Culture
- Cardiac, Anesthesia and Surgical Outcomes
- Infrared Thermography in Medicine
- Hemoglobinopathies and Related Disorders
- Colorectal Cancer Treatments and Studies
- Occupational and environmental lung diseases
- Disaster Response and Management
- Peripheral Nerve Disorders
- Oral and gingival health research
- Ultrasound in Clinical Applications
- Hematological disorders and diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Healthcare cost, quality, practices
- Gun Ownership and Violence Research
- Gastrointestinal disorders and treatments
- Race, History, and American Society
Nottingham University Hospitals NHS Trust
2008-2023
Nottingham Biomedical Research Centre
2019-2023
University of Nottingham
2008-2023
Queen's Medical Centre
2020-2023
National Institute for Health Research
2020-2023
University Hospital of Wales
2022
University of Wolverhampton
2019-2021
University of Birmingham
2021
St. Mark's Hospital
2021
Wolverhampton Hospital
2021
Summary Anaemia is associated with a reduction in quality of life, and common patients colorectal cancer . We recently reported the findings intravenous iron cancer‐associated anaemia (IVICA) trial comparing haemoglobin levels transfusion requirements following or oral replacement anaemic undergoing elective surgery. In this follow‐up study, we compared efficacy at improving life patient group. conducted multicentre, open‐label randomised controlled trial. Anaemic were randomly allocated...
BACKGROUND: Carbon dioxide embolus has been reported as a rare but clinically important risk associated with transanal total mesorectal excision surgery. To date, there exists limited data describing the incidence, factors, and management of carbon in excision. OBJECTIVE: This study aimed to obtain from registries identify trends potential factors for specific this surgical technique. DESIGN: Contributors both LOREC OSTRiCh were invited report their incidence embolus. Case forms collected...
This study aims to determine differences in the on- and off-tumor microbiota between patients with right- left-sided colorectal cancer. Microbiome profiling of tumor tumor-adjacent biopsies from right-sided (n = 17) 7) adenocarcinoma was performed using 16S ribosomal RNA sequencing. Off-tumor alpha beta diversity were significantly different cancer patients. However, no on-tumor observed locations. Comparing showed right colon be enriched species Lachnoclostridium, Selenomonas, Ruminococcus...
Abstract Background The global pandemic caused by SARS-CoV-2 has impacted population health and care delivery worldwide. As information emerges regarding the impact of “lockdown measures” changes to clinical practice worldwide; there is no comparative emerging from United Kingdom with regard major trauma. Methods This observational study a UK Major Trauma Centre matched cohort patients admitted during 10-week period SARS-CoV-2-pandemic (09/03/2020–18/05/2020) historical similar time in 2019...
Background: Anaemia is highly prevalent in people with advanced, palliative cancer yet sufficiently effective and safe treatments are lacking. Oral iron poorly tolerated, blood transfusion offers only transient benefits. Intravenous has shown promise as an treatment for anaemia but its use lacks evidence. Aims: To assess feasibility of the trial design according to screening, recruitment, attrition rates. evaluate efficacy intravenous treat solid tumours, receiving care. Design: A...
Abstract Aim Preoperative iron is frequently used for the correction of anaemia in colorectal cancer surgery. However, enteral intake may promote tumour growth and progression which could influence recurrence patient survival. We explore long‐term outcomes patients receiving either oral or intravenous replacement therapy as part a previous randomized controlled trial. Methods The IVICA trial anaemic to receive (OI, control) (IVI, treatment) prior their elective operation. Follow‐up analysis...
Iron deficiency anemia is a common complication of colorectal cancer and may require iron therapy. Oral can increase the available to gut bacteria alter colonic microbiota. We performed an intervention study compare oral intravenous therapy on tumor-associated (on-tumor) paired non-tumor-associated adjacent (off-tumor) Anemic patients with adenocarcinoma received either ferrous sulphate (n = 16) or ferric carboxymaltose 24). On- off-tumor biopsies were obtained post-surgery microbial...
The Los Angeles County Cancer Surveillance Program abstracts records on almost all cases of cancer occurring in the county. In a study those pleural and peritoneal malignant mesothelioma (MM) that occurred from 1972 to 1979 occupational histories were obtained during interviews, histopathology tumours was reviewed classified by member reference panel who unaware exposure histories. About half had likely asbestos at work. greatest proportion designated as MM pathologist among individuals have...
Pudendal nerve entrapment is a disabling condition which difficult to diagnose and treat. Nantes criteria include the requirement of positive anaesthetic pudendal block that widely used allow identification patients likely benefit from definitive but invasive release. This study aimed determine if blockade under general anaesthesia could temporarily treat in suffering chronic pelvic/perineal pain and/or organ dysfunction.This retrospective analysis prospectively maintained database examined...
An abstract is not available for this content so a preview has been provided. Please use the Get access link above information on how to content.
We recently described metabolic nodal stage (mN) and response (mNR) of cancer the esophagus gastro-esophageal junction (GEJ) to neoadjuvant chemotherapy (NAC) using 18F-FDG PET-CT as new markers disease progression, recurrence, death. aimed validate our findings.Our validation cohort comprised all patients consecutive discovery cohort, staged before after NAC from 2014 2017. Multivariate binary logistic Cox regression were performed.Fifty-one 200 had FDG-avid nodes (25.5%; i.e., lack...
Abstract Objective This study aims to determine the differences in microbial profiles of on- and off-tumour microbiota between patients with right- left-sided colorectal cancer. Design Microbial profiling biopsies from right-sided (n=17) (n=7) adenocarcinoma was performed using 16S ribosomal RNA sequencing. Results Off-tumour alpha diversity is significantly greater compared cancer patients. However, no on-tumour were observed tumour locations. beta showed distinctive bacterial community...
The hospital based Redthread Youth Violence Intervention Programme (YVIP) utilises experienced youth workers to support 11–24 year olds following an episode of violent injury, assault or exploitation who present the Emergency Department (ED) at East Midlands Major Trauma Centre (MTC), Nottingham, UK. YVIP aims promote personal change with aim reducing incidence further similar events. We conducted a retrospective, observational, cohort study examine association between engagement and...
Abstract Background Iron deficiency anaemia is a common complication of colorectal cancer and may require iron therapy. Oral can increase available to gut bacteria alter the colonic microbiota. We performed an intervention study compare oral intravenous therapy on tumour-associated (on-tumour) paired non-tumour-associated adjacent (off-tumour) Anaemic patients with adenocarcinoma received either ferrous sulphate (n=16) or ferric carboxymaltose (n=24). On- off-tumour biopsies were obtained...
To compare patterns and mechanisms of injuries during after the UK Nationwide lockdown COVID-19 pandemic.This prospective cohort study included all major trauma admissions 10-week period nationwide (09/03/2020-18/05/2020), compared with in 10-weeks following full lifting restrictions (04/07/20-12/09/2020). Differences volume, spectrum mechanism presenting post-lockdown were using Fisher's exact Chi-squared tests as appropriate. The associated risk 30-day mortality was examined univariable...
<h3>Introduction</h3> Colorectal cancer (CRC), a major cause of cancer-related mortality, is associated with iron deficiency anaemia (IDA) and typically treated oral iron. Iron an essential nutrient element that required for diverse range biological activities including the immune function (1). However, studies in animal cell line models have shown accumulation gut can generate toxic reactive oxygen species proinflammatory cytokines results tissue damage CRC progression (2). We studied,...