A5042054679- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- RNA modifications and cancer
- High Altitude and Hypoxia
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
Tibet Autonomous Region People's Hospital
2024
Tibet University
2020-2021
Inflammatory factors play an important role in the pathogenesis of Alzheimer’s disease (AD). Byu d Mar 25 (BM25) has been suggested to have protective effects central nervous system. However, effect BM25 on AD not determined. This study aims investigate neuroprotective AD. A total 40 model mice were randomly assigned following five groups (n = 8 per group): + NS group, donepezil and three treated with either 58.39 mg/kg (AD BM25-L), 116.77 BM25-M), or 233.54 BM25-H). The Morris water maze...
Abstract A higher incidence of chronic atrophic gastritis (CAG) is generally considered as a precancerous lesion in gastric cancer (GC). The aim this study was to identify potential molecules involved the pathogenesis CAG Tibetan plateau, hoping help diagnosis and management disease. Atrophic non-atrophic mucosal tissue samples were collected from seven patients with (CG). Differentially expressed lncRNAs, circRNAs, miRNAs, mRNAs between (CNAG) groups identified based on DNBSEQ-G99 RNA...
The unique geographical environment at high altitudes may cause a series of diseases, such as acute altitude reaction, cerebral edema, and pulmonary edema. Gymnadenia conopsea (L.) R. Br. has been reported to have an effect on high-altitude hypoxia. However, the molecular mechanism, especially expression long noncoding RNAs (lncRNAs), is not yet clear.The profiles lncRNAs in hypoxia-induced brain injury mice treated with by using microarray method.A total 226 differentially expressed...