A5002139917- HIV Research and Treatment
- Neonatal and fetal brain pathology
- HIV/AIDS Research and Interventions
- Neuroinflammation and Neurodegeneration Mechanisms
- Primate Behavior and Ecology
- Birth, Development, and Health
- Prenatal Substance Exposure Effects
- Nematode management and characterization studies
- Neuroscience and Neuropharmacology Research
- Cell Image Analysis Techniques
- Point processes and geometric inequalities
- E-Government and Public Services
- Memory and Neural Mechanisms
- Mosquito-borne diseases and control
- Genomics and Phylogenetic Studies
- ICT Impact and Policies
- Oral and Maxillofacial Pathology
- Healthcare Policy and Management
- Gene expression and cancer classification
- Fatty Acid Research and Health
- Banana Cultivation and Research
- Bioinformatics and Genomic Networks
- Career Development and Diversity
- Business Strategies and Management Research
- Oral health in cancer treatment
Howard University
2016-2025
Erie County Medical Center
2019-2023
Virginia Commonwealth University
2023
University of Johannesburg
2018
David H. Murdock Research Institute
2014-2015
North Carolina State University
2005-2015
University of the Witwatersrand
2010-2012
Australian Communications and Media Authority
2011
Université de Montréal
2008-2010
Beaumont Hospital
1998
We have established Meloidogyne hapla as a tractable model plant-parasitic nematode amenable to forward and reverse genetics, we present complete genome sequence. At 54 Mbp, M. represents not only the smallest yet completed, but also metazoan, defines platform elucidate mechanisms of parasitism by what is largest uncontrolled group plant pathogens worldwide. The encodes significantly fewer genes than does free-living Caenorhabditis elegans (most notably through reduction odorant receptors...
Diffusion weighted imaging (DWI) is used to study white-matter fibre organisation, orientation and structural connectivity by means of reconstruction algorithms tractography. For clinical settings, limited scan time compromises the possibilities achieve high image resolution for finer anatomical details signal-to-noise-ratio reliable reconstruction. We assessed potential benefits interpolating DWI datasets a higher before using diffusion tensor model. Simulations straight curved crossing...
Zika virus infection early after birth has deleterious effects on the developing brain and long-term behavioral changes in rhesus macaques.
Abstract Zika virus (ZIKV) infection has a profound impact on the fetal nervous system. The postnatal period is also time of rapid brain growth, and it important to understand potential neurobehavioral consequences ZIKV during infancy. Here we show that in rhesus macaque model resulted long-term behavioral, motor, cognitive changes, including increased emotional reactivity, decreased social contact, loss balance, deficits visual recognition memory at one year age. Structural functional MRI...
Here we report the genome sequence of lesion nematode, Pratylenchus coffeae , a significant pest banana and other staple crops in tropical sub-tropical regions worldwide. Initial analysis 19.67 Mb reveals 6712 protein encoding genes, smallest number found metazoan, although sufficient to make nematode. Significantly, no developmental or physiological pathways are obviously missing when compared model free-living nematode Caenorhabditis elegans which possesses approximately 21 000 genes. The...
Abstract Microglia, the brain’s resident macrophages, participate in development and influence neuroinflammation, which is characteristic of multiple brain pathologies. Diverse insults cause microglia to alter their morphology from “resting” “activated” shapes, vary with stimulus type, location, microenvironment. This morphologic diversity commonly restricts microglial analyses specific regions manual methods. We introduce StainAI, a deep learning tool that leverages 20x whole-slide...
Given South Africa's social and economic development challenges, general human resources management (HRM) practices may not be adequate to address the challenges of transformation executing expected developmental role. A review literature regarding envisaged role Public Service in what is characterized as a state undertaken here, existing inadequacies with respect attracting retaining skilled employees are highlighted. The argument offered that talent should adopted complementary HRM...
Children with fetal alcohol spectrum disorders (FASD) show behavioral and intellectual impairments that indicate frontal lobe dysfunction, but the extent of damage to this region has not been clarified by brain imaging studies. This study uses St Kitts vervet monkey, a species voluntarily consumes beverage alcohol, examine effects prenatal ethanol exposure. Pregnant vervets were allowed drink equivalent 3–5 standard drinks four times week during third trimester. Using unbiased stereology, we...
Alcohol abuse causes 79,000 deaths stemming from severe organ damage in the United States every year. Clinical manifestations of long-term alcohol on cardiac muscle include defective contractility with development dilated cardiomyopathy and low-output heart failure; which has poor prognosis less than 25% survival for more three years. In contrast, low consumption been associated reduced risk cardiovascular disease, however mechanism this phenomenon remains elusive. The aim study was to...
ABSTRACT Pasteuria penetrans is a gram-positive, endospore-forming eubacterium that apparently member of the Bacillus-Clostridium clade. It an obligate parasite root knot nematodes ( Meloidogyne spp.) and preferentially grows on developing ovaries, inhibiting reproduction. Root are devastating pests economically important crop plants difficult to control. Consequently, P. has long been recognized as potential biocontrol agent for nematodes, but fastidious life cycle nature parasitism have...
Activation of multiple pathways is associated with cardiac hypertrophy and heart failure. We previously published that CXCR4 negatively regulates β-adrenergic receptor (β-AR) signaling ultimately limits diastolic (Ca2+) accumulation in myocytes. In isolated adult rat myocytes; CXCL12 treatment prevented isoproterenol-induced interrupted the calcineurin/NFAT pathway. Moreover; specific knockout mice show significant develop dysfunction response to chronic catecholamine exposure an (ISO)...
Despite optimization of preventative measures for vertical HIV-1 transmission, daily, roughly 400 infants become HIV infected, most them through breastfeeding. Viral entry has been presumed to occur in the gastrointestinal tract; however, exact site(s) have not defined. Therefore, we quantified simian immunodeficiency virus (SIV) RNA and DNA oral, intestinal, systemic tissues 15 infant macaques within 48-96 h after oral SIVmac251 exposure. SIV was detected as early 48 h, whereas typically at...
ABSTRACT Prenatal exposure to beverage alcohol is a major cause of mild mental retardation and developmental delay. In nonendangered alcohol‐preferring vervet monkeys, we modeled the most common nondysmorphic form fetal syndrome disorder with voluntary drinking during third trimester pregnancy. Here, report significant numerical reductions in principal hippocampal neurons alcohol‐exposed (FAE) offspring, as compared age‐matched, similarly housed conspecifics isocaloric sucrose exposure....
Pediatric HIV infection remains a global health crisis with worldwide rate of 2.5 million (WHO, Geneva Switzerland, 2009). Children are much more susceptible to HIV-1 neurological impairments compared adults, which is exacerbated by coinfections. A major obstacle in pediatric research sample access. The proposed studies take advantage ongoing simian immunodeficiency virus (SIV) pathogenesis and vaccine test the hypothesis that SIV diminishes neuronal populations neurogenesis hippocampus....
The non-human primate is an important translational species for understanding the normal function and disease processes of human brain. Unbiased stereology, method accepted as state-of-the-art quantification biological objects in tissue sections2, generates reliable structural data features mammalian brain3. key components approach are unbiased (systematic-random) sampling anatomically defined structures (reference spaces), combined with cell numbers size, fiber capillary lengths, surface...
Unbiased stereology is a method for accurately and efficiently estimating the total neuron number (or other cell type) in given area of interest1. To achieve this goal 6-10 systematic sections should be probed covering entire structure. Typically involves processing 1/5 which leaves significant amount material unprocessed. In order to maximize material, we propose an inexpensive preserving fixed tissue as part long-term storage research plan. As sliced processed desired stain or antibody,...
Acute herpes simplex encephalitis (HSE) carries significant morbidity and mortality even after early treatment with antiviral agents (7). As well as causing acute neurological disease, Herpes viruses are associated relapsing - remitting {Varicella Zoster, Epstein-Barr) chronic (Rasmussen encephalitis) disease processes (1). A two-year-old girl developed HSE which was followed by a 10-year neurologic illness characterised asymmetric spastic tetraparesis, pseudobulbar palsy, the opercular...