A5040338821- Acute Myeloid Leukemia Research
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hematopoietic Stem Cell Transplantation
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Immune Cell Function and Interaction
- Protein Tyrosine Phosphatases
- PI3K/AKT/mTOR signaling in cancer
- ATP Synthase and ATPases Research
Universidad de Salamanca
2019-2024
Instituto de Investigación Biomédica de Salamanca
2018-2023
The molecular complexity displayed in acute myeloid leukemia (AML) hinders patient stratification and treatment decisions. Previous studies support the utility of using specific gene panels for this purpose. Focusing on two salient features AML, production reactive oxygen species (ROS) by NADPH oxidases (NOX) metabolism, we aimed to identify a panel that could improve stratification. A pairwise comparison AML versus healthy expression revealed downregulation four members NOX2 complex...
Cancer cells are characterised by an elevated metabolic plasticity and enhanced production of reactive oxygen species (ROS), two features acknowledged as hallmarks in cancer, with a high translational potential to the therapeutic setting. These aspects, that have been traditionally studied separately, fact intimately intermingled. As part their transforming activity, some oncogenes stimulate rewiring processes, whilst simultaneously promoting increased intracellular ROS. In this scenario...
Acute myeloid leukaemia (AML) is a highly heterogeneous disease, however the therapeutic approaches have hardly changed in last decades. Metabolism rewiring and enhanced production of reactive oxygen species (ROS) are hallmarks cancer. A deeper understanding these features could be instrumental for development specific AML-subtypes treatments. NADPH oxidases (NOX), only cellular system specialised ROS production, also involved leukemic metabolism control. NOX2 shows variable expression AML...
The differentiation-based therapy for acute promyelocytic leukemia (APL) is an inspiring example the search of novel strategies aimed at treatment other subtypes myeloid (AML). Thus, discovery new molecular players in cell differentiation becomes a paramount research area to achieve this goal. Here, involvement protein tyrosine phosphatases SHP1 and SHP2 on leukemic cells shown, along with therapeutic possibilities their targeting enhance induction effect phorbol esters. oxidation status...
Background: The differentiation‐based therapy for acute promyelocytic leukemia (APL) is an inspiring example the search of novel strategies aimed at treatment other subtypes myeloid (AML). Thus, discovery new molecular players in cell differentiation becomes a paramount research area to achieve this goal. Aims: To assess involvement protein tyrosine phosphatases SHP1 and SHP2 on leukemic cells along with therapeutic possibilities their targeting enhance induction effect phorbol esters....