A5078367276- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Sphingolipid Metabolism and Signaling
- Autophagy in Disease and Therapy
- Mosquito-borne diseases and control
- RNA regulation and disease
New York Genome Center
2023-2025
New York University
2024-2025
Washington University in St. Louis
2020
Institute of Nutrition, Metabolism and Diabetes
2019
Icahn School of Medicine at Mount Sinai
2019
Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but roles specific cell types in metabolic response to remain be defined. We demonstrate here selective loss receptor α adipocytes recapitulates beneficial effects global deletion, crosstalk between IL10-producing immune is a determinant thermogenesis energy balance. S ingle N uclei A di p ocyte RNA -seq uencing (SNAP-seq)...
While CRISPR-Cas13 systems excel in accurately targeting RNA, the potential for collateral RNA degradation poses a concern therapeutic applications and limits broader adoption transcriptome perturbations. We evaluate extent to which cleavage occurs when
ABSTRACT Chloroquine is an anti-malarial and immunosuppressant drug that has cationic amphipathic chemical properties. We performed genome-wide screens in human cells with chloroquine several other widely used drugs (CADs) including the anti-depressants, sertraline (Zoloft) fluoxetine (Prozac), analgesic nortriptyline (Pamelor), anti-arrhythmic amiodarone (Cordarone), anti-hypertensive verapamil (Calan) to characterize their molecular similarities differences. Despite CADs having different...