A5051531706- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanoparticle-Based Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- Advancements in Battery Materials
- Characterization and Applications of Magnetic Nanoparticles
- 3D Printing in Biomedical Research
- Advanced battery technologies research
- Advanced Battery Technologies Research
- Nanopore and Nanochannel Transport Studies
- Lipid Membrane Structure and Behavior
- Supercapacitor Materials and Fabrication
- ZnO doping and properties
- Advanced Battery Materials and Technologies
- Transition Metal Oxide Nanomaterials
- Micro and Nano Robotics
- MicroRNA in disease regulation
- Advanced Drug Delivery Systems
- Nanofabrication and Lithography Techniques
- Electrohydrodynamics and Fluid Dynamics
- Electrowetting and Microfluidic Technologies
- RNA Interference and Gene Delivery
- Field-Flow Fractionation Techniques
McGill University Health Centre
2021-2025
École de Technologie Supérieure
2018-2025
McGill University
2021-2025
Lynntech (United States)
2012-2013
Tecnológico de Monterrey
2012
Extracellular vesicles (EVs) are secreted by most cell types and play a central role in cell-cell communication. These naturally occurring nanoparticles have been particularly implicated cancer, but EV heterogeneity lengthy isolation methods with low yield make them difficult to study. To circumvent the challenges research, we aimed develop unique synthetic model engineering bioinspired liposomes study properties their impact on cellular uptake. We produced EV-like mimicking physicochemical...
Liposomes nanoparticles (LNPs) are vesicles that encapsulate drugs, genes, and imaging labels for advanced delivery applications. Control tuning liposome physicochemical characteristics such as size, size distribution, zeta potential crucial their functionality. Liposome production using micromixers has shown better control over compared with classical approaches. In this work, we used our own designed fabricated Periodic Disturbance Micromixer (PDM). We Design of Experiments (DoE) Response...
Artificial neural networks (ANN) and data analysis (DA) are powerful tools for supporting decision-making. They employed in diverse fields, one of them is nanotechnology; example, predicting silver nanoparticles size. To our knowledge, we the first to use ANN predict liposome size (LZ). Liposomes lipid used different biomedical applications that can be produced Dean-Forces-based microdevices such as Periodic Disturbance Micromixer (PDM). In this work, DA techniques build a LZ prediction...
Liposomes encapsulate different substances ranging from drugs to genes. Control over the average size and distribution of these nanoparticles is vital for biomedical applications since characteristics determine a high degree where liposomes will accumulate in human body. Micromixers enable continuous flow synthesis liposomes, improving control reproducibility. Recently, Dean dynamics-based micromixers, such as periodic disturbance mixer (PDM), have been shown produce controlled-size scalable...
This work describes the design and simulation using Computational Fluid Dynamics (CFD) of a High Precision Drug Delivery System which is part bionic pancreas. The system interacts in dynamic intelligent way with other subsystems device, includes non-invasive monitor glucose control algorithm for entire system. P-MEM Microfabrication technology brings opportunity to construct these devices scale micrometers, order have device high portability, low power consumption, reliability cost. has...
The shape and dimensions of a micromixer are key elements in the mixing process. Accurately quantifying efficiency enables evaluation performance selection most suitable one for specific applications. In this paper, two methods investigated to evaluate efficiency: numerical model an experimental with software image processing technique. Using calculate efficiency, addition corroborating results increasing their reliability, creates various possible approaches that can be selected depending...
A technique to investigate the properties and performance of new multi-electron metal/air battery systems is proposed presented. method for synthesizing nanoscopic VB2 presented as well step-by-step procedure applying a zirconium oxide coating particles stabilization upon discharge. The process disassembling existing zinc/air cells shown, in addition construction working electrode replace conventional cell anode with anode. Finally, discharge completed VB2/air reported. We show that using...
Abstract Background: Extracellular vesicles (EVs) are couriers in cell-cell communication. Evidence suggests that EV biology, from cargo packing, biodistribution, to cell uptake is a non-random and well-orchestrated process. Substantial efforts have been devoted studying the pathological roles therapeutic potential of EVs. It speculated surface properties, such as membrane proteins, mediate interaction between EVs recipient cells, while enclosed “messages” exert downstream effects. This...
Abstract not Available.
Abstract Background: Extracellular vesicles (EVs) are key mediators of cancer metastasis. EV membrane-associated integrins show organotrophic properties by interacting with microenvironmental stromal cells and extracellular matrix. Specifically, integrin αVβ5 is associated the metastasis cancers remarkable liver tropism, including pancreatic cancer, uveal melanoma, colorectal cancer. Despite importance understanding pathogenic roles EVs, heterogeneity, lengthy isolation, low yields make it...
The integration of microfluidics and droplet-based systems has led to platforms capable characterizing multiple phases inside microchannels which can be an asset for many industries. Furthermore, recent developments on Lab-on-a-PCB devices focus meet design specifications such as the ASSURED criteria (Affordable, Sensitive, Specific, User-friendly, Rapid Robust, Equipment-free, Deliverable end-users). However, most these still present external equipment dependencies, complex setup...
Liposomes nanoparticles (LNPs) are versatile delivery systems that transport from drugs to genes. Liposome physicochemical properties determine how lipid will interact with biological systems. Thus, tuning these characteristics is of paramount importance for developing innovative formulations. Micromixers have shown control average liposome size in a range relevant drug applications (50-200 nm) by changing the flow conditions. However, other factors might dramatically change properties, such...
Abstract Background: Liposomes are spherical vesicles made of a lipid bilayer and effective nanocarriers for drug molecules such as chemotherapeutic agents. Micromixers devices that allow consistent liposome production while more efficiently controlling their characteristics (size, size distribution (PDI), zeta potential) than traditional methods. They provide scalable the ability to control variables total flow rate (TFR) shape liposomes’ characteristics. Periodic Disturbance Mixer (PDM),...
Abstract not Available.
3D-printing has recently attracted the interest of researchers in microfluidics. This technology proved its potential as a way fabricating microchannels offering an automated, low-cost, and straight-forward approach compared with laborious soft-lithography method. enables rapid prototyping. Microfluidic devices can be produced using Fused Deposition Modeling (FDM), channels width order hundreds micrometers. These used for testing new topologies, geometries, concepts, before investing others...
Artificial Neural Networks (ANN) and Data analysis are powerful tools used for supporting decision-making. They have been employed in diverse fields one of them is nanotechnology used, example, predicting particles size. Liposomes nanoparticles different biomedical applications that can be produced Dean Forces-based Periodic Disturbance Micromixers (PDM). In this work, ANN data techniques to build a liposome size prediction model by using the most relevant variables PDM, i.e., Flow Rate...