A5077273115- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Ocular Oncology and Treatments
- Retinal Development and Disorders
- MicroRNA in disease regulation
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Connexins and lens biology
- Retinal Diseases and Treatments
- Alzheimer's disease research and treatments
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Advanced Proteomics Techniques and Applications
- Cancer Mechanisms and Therapy
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
- Ocular Infections and Treatments
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Growth Hormone and Insulin-like Growth Factors
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Digital Marketing and Social Media
McGill University Health Centre
2022-2025
McGill University
2020-2025
Shibaura Institute of Technology
2023-2024
Gansu University of Traditional Chinese Medicine
2024
Gansu Provincial Maternal and Child Health Hospital
2024
University of Alabama at Birmingham
2022-2023
Renmin Hospital of Wuhan University
2019-2022
Wuhan University
2018-2022
University of Sheffield
2021
Dalian Minzu University
2015
Abstract Extracellular vesicles (EVs) play a key role in cellular communication both physiological conditions and pathologies such as cancer. Emerging evidence has shown that EVs are active carriers of molecular cargo (e.g. protein nucleic acids) powerful source biomarkers targets. While recent studies on EV‐associated DNA (EV‐DNA) human biofluids have generated large amount data, there is currently no database catalogues information EV‐DNA. To fill this gap, we manually curated EV‐DNA data...
Abstract Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d from gestational day (GD) 9 to GD20. A subgroup was euthanized for fetuses on GD20, other group went spontaneous labor produce F1 The adult females were mated with normal males F2 F3 generations. fetal...
Uveal melanoma (UM) is the most common intraocular tumor in adults, arises either de novo from normal choroidal melanocytes (NCMs) or pre-existing nevi that stem NCMs and are thought to harbor UM-initiating mutations, commonly GNAQ GNA11. However, there no commercially available NCM cell lines, nor a detailed protocol for developing an oncogene-mutated CM line (MutCM) study UM development. This aimed establish characterize premalignant models human donor eyes recapitulate populations at...
Extracellular vesicles (EVs) are secreted by most cell types and play a central role in cell-cell communication. These naturally occurring nanoparticles have been particularly implicated cancer, but EV heterogeneity lengthy isolation methods with low yield make them difficult to study. To circumvent the challenges research, we aimed develop unique synthetic model engineering bioinspired liposomes study properties their impact on cellular uptake. We produced EV-like mimicking physicochemical...
Purpose With the increasing importance of social media in promoting events, understanding relationship between event followers' motivations and their behaviors on an event's platform becomes a key success factor to attract event-goers. Previous studies exploring attendees have concentrated mostly Western context media, for example, Facebook, festivals; concerning East or China are scant. This study uses Strawberry Music Festival as case researches its two official platforms: WeChat Weibo....
Reperfusion injury after extended ischemia accounts for approximately 50% of myocardial infarct size, and there is no standard therapy. HDAC inhibition reduces size enhances cardiomyocyte autophagy PGC1α-mediated mitochondrial biogenesis when administered at the time reperfusion. Furthermore, a specific autophagy-inducing peptide, Tat-Beclin 1 (TB), However, since SAHA affects multiple pathways in addition to inducing autophagy, whether autophagic flux induced by TB maintains homeostasis...
Prenatal ethanol exposure (PEE) adversely affects the offspring reproductive system. We aimed to confirm susceptibility premature ovarian insufficiency (POI) in female PEE and elucidate its intrauterine programming mechanism. The pregnant Wistar rats were intragastrically administered with 4 g/kg × day of from gestational (GD) 9 20. Offspring parameters detected on GD20, postnatal week (PW) 6 PW12. foetuses showed a decreased number oocytes, increased cell apoptosis upregulated expression...
Uveal melanoma (UM), the most prevalent intraocular tumor in adults, is a highly metastatic and drug resistant lesion. Recent studies have demonstrated cytotoxic anti-metastatic effects of antiprogestin antiglucocorticoid mifepristone (MF) vitro clinical trials involving meningioma, colon, breast, ovarian cancers. Drug repurposing cost-effective approach to bring approved drugs with good safety profiles clinic. This current study assessed MF human UM cell lines different genetic...
Abstract Background: Extracellular vesicles (EVs) are couriers in cell-cell communication. Evidence suggests that EV biology, from cargo packing, biodistribution, to cell uptake is a non-random and well-orchestrated process. Substantial efforts have been devoted studying the pathological roles therapeutic potential of EVs. It speculated surface properties, such as membrane proteins, mediate interaction between EVs recipient cells, while enclosed “messages” exert downstream effects. This...
Abstract Background: Liquid biopsy testing has been implemented in clinical practice because of recent advancements detecting and characterizing circulating tumor DNA (ctDNA). The Food Drug Administration (FDA) approved three ctDNA liquid tests that detect mutations cancers, which can aid clinicians choosing the most effective treatments. While validated for applications, same is not true extracellular vesicle (EV)-associated DNA, another promising biomarker. Previously, our laboratory...
To analyze the clinical phenotype and genetic etiology of three cases glutaric aciduria type 1 (GA1) in Chinese children.
In the pathological process of Alzheimer’s disease, neuronal cell death is closely related to accumulation reactive oxygen species. Our previous studies have found that oxidative stress can activate microtubule affinity-regulating kinases, resulting in elevated phosphorylation levels tau protein specifically at Ser262 residue N1E-115 cells been subjected exposure hydrogen peroxide. This may be one pathogenic mechanisms disease. Vitamin E a fat-soluble, naturally occurring antioxidant plays...
Reactive oxygen species (ROS) play a pivotal role in apoptosis. We reported that Blue Light (BL) induced oxidative stress human retinal pigment epithelial (RPE) cells vitro and increased drusen deposition RPE cell apoptosis eyes. Here, we investigated the mechanisms underlying BL-induced damage to cells. Cells were exposed BL with or without antioxidant N-acetylcysteine. analyzed for levels of ROS, proliferation, viability, mitochondria membrane potential (ΔΨ
Abstract Background: Extracellular vesicles (EVs) are key mediators of cancer metastasis. EV membrane-associated integrins show organotrophic properties by interacting with microenvironmental stromal cells and extracellular matrix. Specifically, integrin αVβ5 is associated the metastasis cancers remarkable liver tropism, including pancreatic cancer, uveal melanoma, colorectal cancer. Despite importance understanding pathogenic roles EVs, heterogeneity, lengthy isolation, low yields make it...
Reactive oxygen species are considered a cause of neuronal cell death in Alzheimer's disease (AD). Abnormal tau phosphorylation is proven pathological hallmark AD. Microtubule affinity-regulating kinases (MARKs) regulate tau-microtubule binding and play crucial role survival. In this study, we hypothesized that oxidative stress increases the Ser262 protein through activation MARKs, which main reason for development We investigated relationship between hyperphosphorylation on MARKs N1E-115...
Introduction: Ischemia/reperfusion (I/R) injury occurs after reperfusion, causing significant myocardial damage. Circulating mitochondrial DNA (mtDNA) levels are elevated in acute infarction patients, and act as Damage Associated Molecular Patterns (mtDNA DAMP) that induce inflammation via immune processes, including the toll-like receptor 9 (TLR9) pathway. However, mtDNA DAMP have not been measured ST-elevation (STEMI) patients before percutaneous coronary intervention (PCI) role of DAMPs...
Abstract Introduction: Extracellular vesicles (EVs) are lipid bilayer-made particles shed by cells to the extracellular space. They carry different cargo proteins, nucleic acids, and other metabolites. EVs play a role in disseminating cancer distant organs communicating with tumor microenvironment prepare metastatic niche also through horizontal transfer of oncogenic traits recipient cells. The EV surface, which includes proteins lipids, plays organotropism cellular uptake. While have been...