A5071528493- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Corneal Surgery and Treatments
- Nanopore and Nanochannel Transport Studies
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Ocular Oncology and Treatments
- Pancreatic and Hepatic Oncology Research
- Retinal Development and Disorders
- Nanoplatforms for cancer theranostics
- Lung Cancer Treatments and Mutations
- Viral Infections and Vectors
- Medical Imaging and Pathology Studies
- RNA Interference and Gene Delivery
McGill University Health Centre
2022-2025
McGill University
2024-2025
Abstract Extracellular vesicles (EVs) play a key role in cellular communication both physiological conditions and pathologies such as cancer. Emerging evidence has shown that EVs are active carriers of molecular cargo (e.g. protein nucleic acids) powerful source biomarkers targets. While recent studies on EV‐associated DNA (EV‐DNA) human biofluids have generated large amount data, there is currently no database catalogues information EV‐DNA. To fill this gap, we manually curated EV‐DNA data...
Uveal melanoma is the most common intraocular tumor in adults. Our group has previously developed a human uveal animal model; however, adverse effects caused by immunosuppressive agent, cyclosporine A, prevented animals from surviving more than 12 weeks. In this study, we tested multiple A doses over an extended disease course up to 20 weeks, providing complete clinical imaging of tumors, histopathological analysis and liquid biopsy biomarker analysis. Twenty albino rabbits were divided into...
Abstract Extracellular vesicles (EVs) play an important role in cell‐cell communication, carrying bioactive molecules including DNA. EV‐associated DNA (EV‐DNA) has created enormous interest the field of biomarkers, particularly related to liquid biopsy. However, its analysis is challenging due nanoscale structure EVs, low abundance EV‐DNA, and surrounding biogenetic debate. Therefore, novel protocols enhance accurate detection EV‐DNA are essential study normal physiology disease states....
Abstract Background: Liquid biopsy testing has been implemented in clinical practice because of recent advancements detecting and characterizing circulating tumor DNA (ctDNA). The Food Drug Administration (FDA) approved three ctDNA liquid tests that detect mutations cancers, which can aid clinicians choosing the most effective treatments. While validated for applications, same is not true extracellular vesicle (EV)-associated DNA, another promising biomarker. Previously, our laboratory...
Abstract Background: Breast cancer is the second most common type of worldwide, and while primary disease often well controlled, metastatic breast (MBC) responsible for majority deaths. MBC cells can metastasize to distant sites including liver, lung, brain bone, mechanisms underlying this organotropism remain largely unknown. has high genetic heterogeneity, studies have reported mutations in oncogenic pathways such as TP53, PIK3CA ESR1. Liquid biopsy been used detect extracellular...