A5029951969- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Gut microbiota and health
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Streptococcal Infections and Treatments
- Reproductive tract infections research
- Antibiotic Use and Resistance
- Vector-borne infectious diseases
- Enterobacteriaceae and Cronobacter Research
- Fecal contamination and water quality
- Insect Pest Control Strategies
- Prion Diseases and Protein Misfolding
- Neonatal and Maternal Infections
- Brucella: diagnosis, epidemiology, treatment
- Viral gastroenteritis research and epidemiology
Hopital Universitaire Habib Bourguiba
2020-2025
University of Sfax
2020-2025
Centre of Biotechnology of Sfax
2023
Background/Objectives: Streptococcus pneumoniae is a leading respiratory pathogen responsible for significant morbidity and mortality, particularly among vulnerable populations. Understanding its antimicrobial resistance patterns serotype distribution crucial guiding treatment prevention strategies. This study aims to examine these trends in S. isolates from Tunisia over two-decade period (2000–2019). Methods: A retrospective time series analysis was conducted on data (n = 4284) gathered...
Brucella melitensis is a zoonotic pathogen that poses worldwide public health challenge. In recent years, whole-genome sequencing has become widely accepted molecular typing method for the genomic epidemiology of brucellosis. This study reports characteristics 24 B. strains isolated from human infections in southern Tunisia over 35 years (1988–2022). We utilized WGS to analyze clonal relationships these strains, their relatedness international sequences, antimicrobial resistance...
Purpose. The prevalence of multidrug-resistant (MDR) Shigella sonnei is increasing globally, raising concerns for public health. In 2022, an outbreak MDR S. was observed in Tunisia. We aimed to evaluate the genetic profile isolates during outbreak, including their clonal relationship, antimicrobial determinants and connection international strains.Methods. this study, we sequenced whole genome 24 strains collected from South Tunisia between July 2022 November 2023. Bioinformatic analysis...
Abstract Background Streptococcus pneumoniae remains a leading cause of morbidity and mortality worldwide. In this study, we sought to analyze serotype distributions, antibiotic resistance, genetic relationships 106 clinical invasive pneumococcal isolates recovered in Tunisia between 2012 2018, prior the routine use conjugate vaccines (PCV). Methods We used multiplex PCR, disk diffusion method and/or E-test, multi-locus sequence typing (MLST). Results The most frequent serotypes were 14...
We aimed to assess the prevalence of nasopharyngeal pneumococcal carriage and determine serotype distribution, antibiotic susceptibility patterns, evolutionary dynamics Streptococcus pneumoniae isolates in healthy under-five children. Nasopharyngeal swabs were collected from children over three survey periods between 2020 2022. All serotyped tested for antimicrobial susceptibility. A total 309 S. collected, with an overall 24.4% (CI95%: [22-26.8%]). These classified into 25 different...
Abstract Objectives To determine antibiotic susceptibility of community-acquired respiratory tract infection (CA-RTI) isolates Streptococcus pneumoniae and Haemophilus influenzae collected in 2015–18 from Tunisia, Kenya Morocco. Methods MICs were determined by CLSI broth microdilution was assessed using CLSI, EUCAST (dose-specific) pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results S. Tunisia (n = 79), 44) Morocco 19) H. 74) only analysed. Low observed with >90% susceptible...
Streptococcus pneumoniae remains a significant cause of morbidity and mortality worldwide despite the overall success vaccine programs. In Tunisia, pneumococcal conjugate vaccines (PCV)10 was introduced in national immunization program April 2019. We sought to determine relationship between serotypes antimicrobial nonsusceptibility S. isolates recovered from clinical samples prevaccination period south Tunisia. A total 504 nonduplicate collected 2012 2018 were tested for susceptibility,...
Introduction In the lack of updated Tunisian epidemiological data, we sought to describe epidemiology Group B Streptococcus (GBS) in pregnant women and newborns.