A5034480906- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Child Nutrition and Feeding Issues
- Attention Deficit Hyperactivity Disorder
- Epilepsy research and treatment
- Treatment of Major Depression
- Pharmaceutical studies and practices
- Schizophrenia research and treatment
- Family and Disability Support Research
- Child Development and Digital Technology
- Behavioral and Psychological Studies
- Receptor Mechanisms and Signaling
- Congenital heart defects research
- Transgenic Plants and Applications
- Child and Adolescent Health
- Food Allergy and Anaphylaxis Research
- Genomic variations and chromosomal abnormalities
- Drug-Induced Adverse Reactions
- Pancreatic function and diabetes
- Child and Adolescent Psychosocial and Emotional Development
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Respiratory Support and Mechanisms
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
IRCCS Eugenio Medea
2009-2024
Azienda Ospedaliera San Gerardo
2019
University of Milan
1991-2015
Ospedale Maggiore
2006
Deutsches Herzzentrum der Charité
2003
Istituti Clinici di Perfezionamento
2003
Deutsches Herzzentrum München
2003
Fundação Universitária de Cardiologia
2003
Hôpital Necker-Enfants Malades
2003
Assistance Publique – Hôpitaux de Paris
2003
Background Early application of prolonged prone positioning has been shown to improve patient survival in moderate severe adult respiratory distress syndrome (ARDS) patients. Prone position is a key component lung protective mechanical ventilation association with low tidal volume and neuromuscular blocking agents patients ARDS. Pressure sores are the major complication. The rate complication lowering increase center expertise. Aims aim this study was examine onset pressure other...
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that can be associated with intellectual disability (ID) and epilepsy (E). The etiology the pathogenesis of this in most cases still to clarified. Several studies have underlined EEG recordings children these clinical pictures are abnormal, however precise frequency abnormalities their relationship pathogenic mechanisms particular epileptic seizures unknown. We retrospectively reviewed 292 routine polysomnographic...
Few studies have investigated functional and behavioural variables of Cornelia de Lange Syndrome (CdLS) in a large sample individuals. The aim this study is to provide greater insight into the clinical, cognitive characteristics that are associated with CdLS.In total, 56 individuals CdLS participated study. During hospitalization, their mothers received number questionnaires complete. phenotype was using following scales: Developmental Behaviour Scale Primary Carer Version; Autism Checklist;...
Objectives: Gene-environment interaction is an emerging hypothesis to expound not only the autism pathogenesis but also increased incidence of neurodevelopmental disorders (such as autistic spectrum disorder, attention-deficit, hyperactivity disorder). Among xenobiotics, mycotoxins are worldwide contaminants food that provoke toxicological effects, crucially resembling several symptoms associated with such oxidative stress, intestinal permeability, and inflammation. Here, we focused on a...
Abstract Early identification of autism spectrum disorder (ASD) is crucial for the formulation effective intervention programs. Language deficits may be a hallmark feature ASD and language delay observed in shows striking similarities to that children with impairment (LI). Auditory processing are seen both LI ASD, however, they have not previously been compared directly using Event-Related Potentials (ERPs) two at-risk populations. This study aims characterize infants (HR-ASD) at...
Environmental factors and genetic susceptibility are implicated in the increased risk of autism spectrum disorder (ASD). Mycotoxins agricultural contaminants fungal origin that represent real for human health especially children. Thus, main hypothesis this work is deterioration clinical manifestation children may result from exposure to mycotoxins through consumption contaminated food. Within a cross-sectional study, group autistic (n = 172) controls 61) (siblings non-parental) were...
Abstract The notion of “vitality form” has been coined by Daniel Stern to describe the basic features action, which may reflect mood or affective state an agent. There is general consensus that vitality forms substantiate social interactions in children as well adults. Previous studies have explored with Autism Spectrum Disorder (ASD)’s ability copying and recognizing actions performed others. In this paper we investigated, for first time, how ASD express different when acting themselves. We...
Objective: Gap in knowledge on benefit/risk ratio of second generation antipsychotics (SGA) the paediatric population represents a challenge for scientific community. This study aims to analyse all suspected adverse drug reactions (ADRs) SGA observed during period; compare safety profiles risperidone and aripiprazole; evaluate effect switching from aripiprazole or first antipsychotic (FGA).Methods: Prospective analysis spontaneously reported ADRs concerning 184 outpatients between 2012...
Abstract The development of children who have syndromes with mental retardation and/or language delay can be worsened by sensorineural or conductive hearing loss (HL). Given the existing scarcity data, we investigated prevalence otitis media effusion HL in 50 Cornelia de Lange syndrome (CdLS) aged 1–18 years, and its impact on children's performance. underwent otological audiological examinations order to ascertain relative frequencies impairment; their demographic clinical data were...
Since involved in synaptic transmission and located on X-chromosome, neuroligins 3 4X have been studied as good positional functional candidate genes for autism spectrum disorder pathogenesis, although contradictory results reported. Here, we performed a case-control study to assess the association between noncoding genetic variants NLGN3 NLGN4X autism, an Italian cohort of 202 autistic children analyzed by high-resolution melting. The were first compared with data from 379 European healthy...
The practical effectiveness of second-generation antipsychotics in children and adolescents is an understudied issue. It a crucial area study, though, because such patients are often treated for long-lasting disorders.We carried out 24-month (March 2012-March 2014) observational study on unselected population pediatric outpatients with risperidone, aripiprazole, olanzapine, or quetiapine aiming to (1) describe drug use, (2) compare post hoc the discontinuation rates due specific causes dose...
Psychological and mental health consequences of large-scale anti-contagion policies are assuming strong relevance in the COVID-19 pandemic. We proposed a specific focus on large sample children with Autism Spectrum Disorder (ASD), developing an ad hoc instrument to investigate changes occurred (sub-)domains during period national lockdown (Italy). Our questionnaire, named AutiStress, is both context-specific (being set pandemic scenario) condition-specific structured taking into account...