The vast majority of the mammalian genome is transcribed giving rise to many different types noncoding RNAs. Among them, long RNAs are most numerous and functionally versatile class. Indeed, lncRNA repertoire might be as rich proteome. LncRNAs have emerged key regulators gene expression at multiple levels. They play important roles in regulation development, differentiation maintenance cell identity they also contribute disease. In this review, we present recent advances biology lncRNAs...

Abstract Neuroblastoma is the most common extracranial childhood tumor diagnosed in first year of life. A complete molecular understanding neuroblastoma necessary to identify novel therapeutic targets for their management, particularly high-risk groups. Many transcription factors play an essential role during development, and expression restricted specific cells/tissues after development completed. PAX3 belongs paired box family involved various cellular processes like proliferation,...

Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric muscle cancer, which arrested during the process of skeletal differentiation. In myoblast cells, ectopic expression histone H3 lysine 9 (H3K9) methytransferase KMT1A blocks differentiation by repressing a myogenic gene program. this study, we tested hypothesis that activation KMT1A-mediated program transcriptional repression prevents ARMS cells from differentiating. We investigated whether represses differentiation-associated genes...

A new <italic>7</italic>-diethylamino-<italic>4</italic>-hydroxycoumarin appended acylhydrazone probe was prepared and utilized for the sequential detection of Al³⁺/PPi in a reversible off–on–off emissive manner. The various practical applications were established.

Alveolar rhabdomyosarcoma comprises a rare highly malignant tumor presumed to be associated with skeletal muscle lineage in children. The hallmark of the majority alveolar is chromosomal translocation that generates PAX3-FOXO1 fusion protein, which an oncogenic transcription factor responsible for development phenotype this tumor. cells are dependent on activity PAX3-FOXO1, and its expression status tumors correlates worst patient outcome, suggesting blocking may attractive therapeutic...

The chimeric PAX3-FKHR transcription factor is present in a majority of alveolar rhabdomyosarcoma (ARMS), an aggressive skeletal muscle cancer childhood. PAX3-FKHR-mediated aberrant myogenic gene expression resulting escape from terminal differentiation program believed to contribute ARMS development. In differentiation, activation AKT pathway leads and differentiation. Here, we report that acts, part, by modulating transcriptional activity via phosphorylation the maintenance blockade...

Master transcription factor MyoD can initiate the entire myogenic gene expression program which differentiates proliferating myoblasts into multinucleated myotubes. We previously demonstrated that histone methyltransferase KMT1A associates with and inhibits in myoblasts, must be removed to allow differentiation proceed. It is known pro-myogenic signaling pathways such as PI3K/AKT p38α MAPK play critical roles enforcing associations between transcriptional activators, while removing...

Abstract Tumor‐specific alterations at the p53 gene locus in 30 human vestibular schwannomas (VS) comprising 10 confirmed NF2 cases and 20 sporadic were analyzed. We found loss of heterozygosity (LOH) first intron 54% informative cases. This is report showing LOH a significant number VS both show event. Increased levels normal size mRNA protein all tumors Thus appears to be deregulated suggesting that may associated with tumor progression VS. There was negative correlation patients' age...

Alveolar rhabdomyosarcoma (aRMS) is an aggressive subtype of the most common soft tissue cancer in children. A hallmark aRMS tumors incomplete myogenic differentiation despite expression master regulators such as MyoD. We previously reported that histone methyltransferase KMT1A suppresses MyoD function to maintain undifferentiated state cells, and loss sufficient induce suppress malignant phenotypes these cells. Here, we develop a chemical compound screening approach using MyoD-responsive...

Retiform hemangioendothelioma is a rare intermediate or borderline neoplasm of the blood vessels that mostly occurs in extremities. Here we report unique case retiform presented external auditory canal. 58-year-old male patient with complaint right ear swelling for 4 years. On examination, spherical was found occluding view The tumor removed surgically. Intraoperatively, mass attached to outer part canal near root helix. Histopathology resected showed typical features hemangioendothelioma....

The primary human brain tumors account for less than 2% of all cancers but yet cause a disproportionate burden cancer related morbidity and mortality. These are the second most common form in pediatric population, next only to leukemia hence leading death due children. Among adults they rank 6 th 8 frequency neoplasms 2 nd 5 men women respectively who belong age group 20 39 years. survival rates tumor patients have not changed over past several decades. p53 gene is one important intensively...

SUMMARY Isoform switching in deciphering differentiation signals into myogenic transcriptional output remains unexplored. Here, we report a distinct function of muscle-specific metavinculin isoform canonical to non-canonical Wnt-pathways establish skeletal muscle differentiation. Metavinculin expression is specifically associated with differentiation, regeneration and absent proliferating myoblasts. During metavinculin-specific exon retention facilitated by the direct binding Rbfox1 its...

Human brain tumors are a group of that primarily originate from the central nervous system. These vary in their etiology, histology, biology, prognosis and treatment. The overall incident rate reported to be lower compared other human tumor types. However, it results disproportionately high mortality due cancers. retinoblastoma gene (RBI) is first suppressor (TS) identified one most widely studied genes variety Data these studies showed important cell cycle regulatory genes. Inactivation RBI...

This study is done to evaluate the effect of spleen tyrosine kinase inhibitor (BAY 61-3606), cyclin-dependent (CDKi), and sodium butyrate (Na-Bu) on level phosphorylation p53 protein its binding murine double minute 2 (MDM2) homologue in human vestibular schwannomas (VS). Primary cultures tumor tissues were treated individually with optimum concentrations these small molecules vitro . The results indicate modulation status ability MDM2 samples as compared untreated control. three individual...

Tumorigenesis is a multistep process where normal control of cell proliferation and cell-cell interactions are lost this leads to transformation cells into tumor cell. Tumorigenic involves atleast two classes genes: (a) Oncogenes (b) suppressor (TS) genes. Activated oncogenes known aid uncontrolled growth whereas TS genes inhibit proliferation. The human retinoblastoma gene, RB1, the first gene be identified. Vestibular schwannomas (VS) one most common tumors central nervous system. Possible...

Human vestibular schwannomas (VS) arise from the Schwann cells of branch vestibulo-cochlear nerve or eighth cranial nerve. Although p53 gene mutations, both germ line and somatic, have been reported in many brain tumors, a scant contribution is speculated for human schwannomas. However, altered structure expression age dependent phosphorylation protein specifically at Ser 392 position only younger patients VS tumors these results show an important role A functional NF2 its protein, merlin,...