A5052342275- Nanoparticles: synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Circular RNAs in diseases
- Heavy Metal Exposure and Toxicity
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Phytochemistry and Biological Activities
- Fluoride Effects and Removal
- Flavonoids in Medical Research
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Medicinal Plants and Bioactive Compounds
- Mercury impact and mitigation studies
- Cancer-related molecular mechanisms research
- Platelet Disorders and Treatments
- Pregnancy and preeclampsia studies
- Natural Antidiabetic Agents Studies
- Cancer-related gene regulation
- Heat shock proteins research
- Alzheimer's disease research and treatments
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
University of Michigan
2021-2025
Michigan United
2025
Bharathiar University
2014-2022
Nano-copper oxides are a versatile inorganic material. As result of their versatility, the immense applications and usage end up in environment causing concern for lifespan various beings. The ambiguities surround globally on toxic effects copper oxide nanoparticles (CuO-NPs). Hence, present study endeavored to sub-lethal acute exposure developing zebrafish embryos. 48 hpf LC50 value was about 64 ppm. Therefore, we have chosen dose 40 60 ppm study. Accumulation CuO-NPs evidenced from SEM-EDS...
ABSTRACT The aim of this study was to determine whether repeated exposure iron oxide nanoparticles (Fe 2 O 3 ‐NPs) could be toxic mice testis. Fe ‐NPs (25 and 50 mg/kg) were intraperitoneally administered into once a week for 4 weeks. Our showed that have the ability cross blood‐testis barrier get findings resulted in accumulation which evidenced from content Furthermore, 25 mg/kg administration increased reactive oxygen species, lipid peroxidation, protein carbonyl content, glutathione...
The effect of fisetin on autophagy in hepatocellular carcinoma remains uncovered. HepG2 cells were exposed to different concentrations (25, 50, and 100 µM) for 24 h. also treated with rapamycin chloroquine alone or combination fisetin. Autophagic flux formation ATP levels determined. changes autophagic markers AMPK signaling proteins analyzed using qRT-PCR Western blotting. Cyto-ID staining followed by flow cytometry showed that decreased a dose-dependent manner. In gene expression analysis,...
Fisetin (3,7,3',4'-tetrahydroxyflavone), a bioactive dietary flavonoid, intrigued scientists for its anticancer potential against various cancer types. We investigated the fisetin-induced inhibition of growth and survival human hepatocellular carcinoma. decreased cell viability proliferation HepG2 cells as revealed from MTT clonogenicity assays. Cell cycle arrest in G2/M phase was observed. Annexin V/propidium iodide (PI) staining followed by flow cytometry that fisetin induced both...
Abstract The Keap1‐Nrf2‐ARE system serves as a premier defence mechanism to curb oxidative stress, which remains one of the major causes ageing and pathogenesis in various diseases. Nrf2 is principal master regulator cellular system, its activation prospective therapeutic approach against chronic One recent strategies disrupt Keap1‐Nrf2 protein‐protein interaction (PPI) that alters docking Keap1 with by compounds occupying position blocking interface Nrf2. In this study, we made an attempt...
AbstractTitanium dioxide (TiO2) produced globally is estimated to reach 6.8 million tonnes in 2016. The extensive use of TiO2 will thus result environmental exposure these nanoparticles (NPs). At present, there limited information on the ecotoxicolgical consequences NP focusing aquatic life. Hence, aim this study was examine toxicity TiO2NPs address risks using a zebrafish model system. In both qualitative and quantitative analyses, found accumulate gills treated groups. Decreased activity...
Abstract Arsenic (As), a potent environmental toxin, causes cardiac functional impairments. Ferulic acid (FA), ubiquitous dietary hydroxycinnamate, exerts beneficial effects on human health. Hence, the present study investigated effect of FA myocardial oxidative stress parameters, ATP level, status cytoskeleton intermediate filaments—desmin and vimentin, AMPK signaling proteins in As‐intoxicated rats. Wistar rats were administered orally with FA‐40 mg/kg As‐5 alone combination for 30 days....
Acute fluoride (F