A5039591871- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Carbohydrate Chemistry and Synthesis
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Telomeres, Telomerase, and Senescence
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Parasitic Infections and Diagnostics
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Chromatin Remodeling and Cancer
- Protein Tyrosine Phosphatases
- Invertebrate Immune Response Mechanisms
- Genetic Syndromes and Imprinting
Consejo Nacional de Investigaciones Científicas y Técnicas
2010-2025
Instituto de Investigaciones en Ciencias de la Salud
2020-2025
Universidad Nacional de Córdoba
2009-2025
Research Centre in Biological Chemistry of Córdoba
2010-2019
Instituto de Investigación Médica Mercedes y Martín Ferreyra
2017
In somatotroph tumors, over 50% of patients do not respond satisfactorily to the octreotide (OCT) treatment. Stimulation SSTR2 with OCT triggers anti-proliferative signaling pathways mediated by phosphatase SHP2. This can exercise its functions through STAT3, SHP2/STAT3 subcellular localization being crucial for understanding mechanisms action. We investigated expression SHP2 in somatotrophs role on cell proliferation, effects STAT3 phosphorylation, and localization, using vitro a...
Abstract Described in several epithelial cancer cells, Tn- (GalNAcα1-O-Ser/Thr) and T- (Galβ3GalNAcα1-O-Ser/Thr) antigens are examples of tumor-associated antigens. Increased expression T-antigens is associated with tumor invasion metastasis, patients high concentration anti-Tn anti-T antibodies have a more benign evolution pathology. Asialofetuin (ASF) ovine submaxillary mucin (OSM) two glycoproteins that expose Tn-antigen, respectively. In this work, using ASF or OSM we affinity-purified...
In eukaryotes, histone lysine methylation is associated with either active or repressed chromatin states, depending on the status of methylation. Even when amino‐terminus Giardia lamblia histones diverges from other organisms, these regions contain residues that are potential targets for When we examined role methyltransferase 1 (HMT1) in regulation encystation process by giardial (GlHMT1) overexpression downregulation, observed an increase a decrease cyst production, respectively, compared...
The molecular mechanisms underlying the capability of pituitary tumours to avoid unregulated cell proliferation are still not well understood. However, NF-κB transcription factor, which is able modulate only cellular senescence but also tumour progression, has emerged as a targeted candidate. This work was focused on role in during progression experimental tumours. Also, contribution signalling pathways senescence-associated activation and secretory phenotype (SASP) pro-survival-NF-κB target...
Axinella corrugata lectin 1 (ACL-1) was purified from aqueous extracts of the marine sponge, corrugata. ACL-1 strongly agglutinates native rabbit erythrocytes. The hemagglutination is inhibited by N-acetyl derivatives, particularly N, N', N"-triacetylchitotriose, N-acetyl-D- glucosamine, N-acetyl-D-mannosamine and N-acetyl-D-galactosamine. We investigated capacity biotinylated to stain several transformed cell lines including breast (T-47D, MCF7), colon (HT-29), lung (H460), ovary (OVCAR-3)...
Cancer‐associated mucins show frequent alterations of oligosaccharide chain profile. Terminal structures may be deleted, thereby exposing normally ‘cryptic’ such as Tn (GalNAcα‐ O ‐Ser/Thr) and T antigen (Galβ1‐3GalNAcα‐ ‐Ser/Thr). Overexpression these commonly hidden glycoforms, reduced level naturally occurring anti‐T or anti‐Tn antibodies, is associated with epithelial tumor progression aggressiveness. The lectin from the common edible mushroom Agaricus bisporus (ABL) shows high affinity...
Polypeptide GalNAc-transferases (ppGalNAc-Ts) are a family of enzymes that catalyze the initiation mucin-type O-glycosylation. All ppGalNAc-T members contain common (QXW)3 motif, which is present in R-type lectin group. The acetylation site K521 part QKW motif β-trefoil domain ppGalNAc-T2. We used combination and site-directed mutagenesis approaches to examine functional role Binding assays non-acetylated acetylated forms mutant ppGalNAc-T2K521Q various naked αGalNAc-glycosylated mucin...
Interest in epigenetics has gained substantial momentum as a result of their identified role the regulation tumor progression well ability to pharmacologically target genes. Pituitary neuroendocrine tumors (PitNETs) tend be inactivated via epigenetic modification, and although emerging evidence suggested for factors PitNET tumorigenesis, degree which these may targeted by new therapeutic strategies still remains poorly understood. The objective present study was examine participation...