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George Eng

ORCID: 0000-0003-0272-9623
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A5051128964
Research Areas
  • Immunotherapy and Immune Responses
  • vaccines and immunoinformatics approaches
  • Viral-associated cancers and disorders
  • Advanced biosensing and bioanalysis techniques
  • Animal Virus Infections Studies
  • Studies on Chitinases and Chitosanases
  • Monoclonal and Polyclonal Antibodies Research
  • RNA Interference and Gene Delivery
  • RNA modifications and cancer
  • Extracellular vesicles in disease
  • T-cell and Retrovirus Studies
  • Cancer Genomics and Diagnostics
  • Chromosomal and Genetic Variations
  • Circular RNAs in diseases
  • Galectins and Cancer Biology
  • Chemokine receptors and signaling
  • interferon and immune responses
  • Cell Adhesion Molecules Research
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction

Mass General Brigham
 2023

Harvard University
 2023

Massachusetts Institute of Technology
 2023

 Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer Yılmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

Abstract Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring response. Although proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity these applications. Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) is a transposable element overexpressed in carcinomas high-risk precursors during carcinogenesis with negligible expression normal tissues, suggesting ORF1p could...

10.1158/2159-8290.cd-23-0313 article EN cc-by-nc-nd Cancer Discovery 2023-09-12
 Supplementary Figure 24 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Calibration curves for “3rd Generation” Simoa assays.</p>

10.1158/2159-8290.24962054.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 20 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Additional second-generation ORF1p Simoa assay measurements in healthy and cancer patients.</p>

10.1158/2159-8290.24962066.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 19 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Assay validation for second-generation ORF1p Simoa assays.</p>

10.1158/2159-8290.24962072.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 27 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Kaplan-Meier Survival Analysis by ORF1p.</p>

10.1158/2159-8290.24962045.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 19 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Assay validation for second-generation ORF1p Simoa assays.</p>

10.1158/2159-8290.24962072 preprint EN cc-by 2024-01-08
 Supplementary Figure 16 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Screening of multimeric nanobodies for ORF1p detection with Simoa.</p>

10.1158/2159-8290.24962081.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 4 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Circulating ORF1p levels in patients with IPMN</p>

10.1158/2159-8290.24962033.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 3 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Circulating ORF1p levels in lung cancer patient cohort</p>

10.1158/2159-8290.24962036.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 12 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Screening of newly developed monoclonal antibody candidates.</p>

10.1158/2159-8290.24962093 preprint EN cc-by 2024-01-08
 Supplementary Figure 20 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Additional second-generation ORF1p Simoa assay measurements in healthy and cancer patients.</p>

10.1158/2159-8290.24962066 preprint EN cc-by 2024-01-08
 Supplementary Figure 18 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Second round of screening newly developed monoclonal antibody and dimeric nanobody reagent pairs in patient plasma.</p>

10.1158/2159-8290.24962075.v1 preprint EN cc-by 2024-01-08
 Data from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<div>Abstract<p>Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring response. Although proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity these applications. Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) is a transposable element overexpressed in carcinomas high-risk precursors during carcinogenesis with negligible expression normal tissues,...

10.1158/2159-8290.c.7014641 preprint EN 2024-01-08
 Supplementary Figure 21 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>(obtained from Drapkin Lab at the University of Pennsylvania).Circulating CA125 and HE4 levels, as measured by Simoa, in ovarian cancer patient cohort.</p>

10.1158/2159-8290.24962063.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 9 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Nanobody generation</p>

10.1158/2159-8290.24962018.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 24 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Calibration curves for “3rd Generation” Simoa assays.</p>

10.1158/2159-8290.24962054 preprint EN cc-by 2024-01-08
 Supplementary Figure 11 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Engineered Nanobody constructs.</p>

10.1158/2159-8290.24962096.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 17 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>First round of screening newly developed monoclonal antibody and dimeric nanobody reagent pairs in patient plasma.</p>

10.1158/2159-8290.24962078 preprint EN cc-by 2024-01-08
 Supplementary Figure 17 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>First round of screening newly developed monoclonal antibody and dimeric nanobody reagent pairs in patient plasma.</p>

10.1158/2159-8290.24962078.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 7 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Genomics analysis of lung cancer patient cohort.</p>

10.1158/2159-8290.24962024 preprint EN cc-by 2024-01-08
 Supplementary Figure 27 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Kaplan-Meier Survival Analysis by ORF1p.</p>

10.1158/2159-8290.24962045 preprint EN cc-by 2024-01-08
 Supplementary Figure 22 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Circulating ORF1p levels in breast cancer patients.</p>

10.1158/2159-8290.24962060 preprint EN cc-by 2024-01-08
 Supplementary Figure 25 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Second round of screening newly developed “3rd generation” assays using dimeric nanobody detectors.</p>

10.1158/2159-8290.24962051.v1 preprint EN cc-by 2024-01-08
 Supplementary Figure 2 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
OPENALEX - Publications 
Martin S. Taylor Connie Wu Peter C. Fridy Stephanie J. Zhang Yasmeen Senussi and 54 more Justina C. Wolters Tatiana Cajuso Wen‐Chih Cheng John D. Heaps Bryant D. Miller Kei Mori Limor Cohen Hua Jiang Kelly R. Molloy Brian T. Chait Michael Goggins Irun Bhan Joseph W. Franses Xiaoyu Yang Mary‐Ellen Taplin Xinan Wang David C. Christiani Bruce E. Johnson Matthew Meyerson Ravindra Uppaluri Ann Marie Egloff Elyssa N. Denault Laura M. Spring Tian‐Li Wang Ie‐Ming Shih Jennifer E. Fairman Euihye Jung Kshitij S. Arora Osman H. Yilmaz Sonia Cohen Tatyana Sharova Gary Chi Bryanna L. Norden Yuhui Song Linda T. Nieman Leontios Pappas Aparna R. Parikh Matthew R. Strickland Ryan B. Corcoran Tomas Mustelin George Eng Ömer H. Yilmaz Ursula A. Matulonis Andrew T. Chan Steven J. Skates Bo R. Rueda Ronny Drapkin Samuel J. Klempner Vikram Deshpande David T. Ting Michael P. Rout John LaCava David R. Walt Kathleen H. Burns

<p>Circulating ORF1p levels in eight stage I ovarian cancer patients</p>

10.1158/2159-8290.24962069.v1 preprint EN cc-by 2024-01-08
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