W. L. Flowers

ORCID: 0000-0003-0280-5702
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About
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Research Areas
  • Animal Behavior and Welfare Studies
  • Genetic and phenotypic traits in livestock
  • Reproductive Physiology in Livestock
  • Animal Nutrition and Physiology
  • Sperm and Testicular Function
  • Reproductive Biology and Fertility
  • Effects of Environmental Stressors on Livestock
  • Animal Genetics and Reproduction
  • Trace Elements in Health
  • Plant Micronutrient Interactions and Effects
  • Neuropeptides and Animal Physiology
  • Cancer, Stress, Anesthesia, and Immune Response
  • Fatty Acid Research and Health
  • Insect and Pesticide Research
  • Birth, Development, and Health
  • Receptor Mechanisms and Signaling
  • Seed Germination and Physiology
  • CRISPR and Genetic Engineering
  • Animal Virus Infections Studies
  • Genetic Mapping and Diversity in Plants and Animals
  • TGF-β signaling in diseases
  • Heavy Metal Exposure and Toxicity
  • Genetically Modified Organisms Research
  • Teratomas and Epidermoid Cysts
  • Livestock Farming and Management

University of Virginia Health System
2024

North Carolina State University
2013-2023

Papworth Hospital
2023

University of Cambridge
2023

Cambridge University Hospitals NHS Foundation Trust
2020

University of Mississippi Medical Center
2000-2019

North Central State College
2011-2017

State Street (United States)
2000

Mayo Clinic
1993

Zoological Society of San Diego
1991

Two hundred and sixteen weanling gilts (6.65 ± 0.08 kg) were used to determine the effects of decreasing supplemental concentrations Zn, Cu, Fe, Mn, trace mineral source (inorganic vs. chelated) on growth performance, status, fecal from weaning through development. The study was conducted over three trials with 72 pigs in each trial. Gilts blocked by weight randomly assigned either 1) control, 2) reduced inorganic, or 3) chelated minerals. control diet supplemented 25, 150, 180, 60 mg/kg Mn...

10.2527/2004.8272140x article EN Journal of Animal Science 2004-07-01

Ninety-six multiparous sows were randomly assigned into 2 different gestation housing systems on d 35 of gestation: individual gestational crates (n = 24) or small groups with 3 in pens 24). Sows classified 4 treatments based and social ranks within each pen: housed control treatment (CON), destined to high, middle, low pen high rank (HR), middle (MR), (LR). The a was determined by their winning percentage during aggressive interactions observed for 4-d period after mixing gestation. Plasma...

10.2527/jas.2013-6388 article EN Journal of Animal Science 2013-10-22

Follicular growth rates were determined by histological examination of ovaries five prepubertal gilts following treatment with the stathmokinetic agent colchicine. One ovary from each was removed surgically and then colchicine (n = 3) or saline 2) infused i.v. Precisely 2 h after colchicine, remaining removed. Ovaries processed for analyses sectioned at 10 μm; every twentieth section stained hematoxylin periodic acid-Schiffe’s. Sections viewed a projection microscope individual follicles...

10.1095/biolreprod47.3.485 article EN Biology of Reproduction 1992-09-01

This study was designed to investigate the effects of weaning age on specific components adaptive immune system in pigs. Twenty-three crossbred pigs were randomly assigned 1 3 treatments: at 14 (14D, n = 8), 21 (21D, 7), or 28 (28D, 8) d age. Peripheral blood samples, obtained when 13, 15, 20, 22, 27, 29, and 35 age, analyzed for peripheral cell percentages concentrations neutrophils, lymphocytes, T subsets, mature B cells, plasma cortisol concentrations. For each groups, increased (P <...

10.2527/jas.2010-3470 article EN Journal of Animal Science 2011-09-17

Thirty weanling, crossbred barrows (SUS SCROFA) were used to determine the effects of amount and source dietary Cu on small intestinal morphology lipid peroxidation, metabolism, mRNA expression proteins involved in hepatic homeostasis. At 21 d age, pigs stratified by BW (6.33 ± 0.23 kg) allocated 1 following treatments: i) control (no supplemental Cu; 6.7 mg Cu/kg), ii) 225 Cu/kg diet from sulfate (CuSO(4)), or iii) tribasic chloride (TBCC). Pigs housed 2 per pen fed a 3-phase regimen until...

10.2527/jas.2011-4403 article EN Journal of Animal Science 2012-05-15

Hyperglycemia stimulates secretion of αVβ3 ligands from vascular cells, including endothelial resulting in activation the integrin. This study determined whether blocking ligand occupancy would inhibit development diabetic nephropathy. Ten pigs received an F(ab)2 fragment antibody directed against extracellular domain β3-subunit, and 10 a control IgG for 18 weeks. Nondiabetic excreted 115 ± 50 μg protein/mg creatinine compared with F(ab)2-treated animals (218 57 μg/mg), whereas treated...

10.1210/en.2014-1318 article EN Endocrinology 2014-08-29

Forty-eight weanling barrows were used to determine the effects of amount and source dietary Cu on metabolism, oxidative stress in duodenum, VFA ratios cecum pigs short-term feeding. At 21 d age, newly weaned stratified by BW (7.03 ± 1.20 kg) equally assigned 1 following treatments: 1) control (5 mg supplemental Cu/kg diet from CuSO4), 2) 225 CuSO4, or 3) tribasic chloride (TBCC). Pigs housed 2 per pen fed a complex until harvest 11 12. During harvest, bile liver obtained for mineral...

10.2527/jas.2014-8082 article EN Journal of Animal Science 2015-05-29

A study was conducted to examine effects of mating systems composed natural service (NS) and AI in swine on farrowing rate, litter size, labor requirements. Sows gilts were bred once per day via one the following treatments (d 1/d 2): NS/NS, NS/AI, AI/AI, NS/none. Gilts with NS/NS had higher (P less than .05) rates NS/none matings. Similarly, NS/AI gilts. Numbers pigs born alive greater AI/AI In sows, a treatment x time interaction .01) present for rate. treatment, rate increased from 70.0%...

10.2527/1992.703615x article EN Journal of Animal Science 1992-03-01

An experiment was conducted to determine long-term effects of dietary boron (B) on reproductive and bone characteristics in gilts. Weanling gilts (n = 50) were allotted 10 pens based weaning weight litter origin. Pens randomly assigned receive one two treatments that consisted a basal diet low B (control) the supplemented with 5 mg B/kg as sodium borate. Gilts remained their respective experimental diets throughout nursery phase, growing-finishing sexual maturity, breeding, gestation,...

10.2527/2002.801154x article EN Journal of Animal Science 2002-01-01

A cell culture system was developed to study the function of porcine granulosa cells from primary and secondary follicles. Primary follicles were isolated 1- 3-day-old pigs. Secondary 50- 60-day-old Follicles after a digestion for 15 min with 0.25% trypsin followed by 1000 U DNAase. plated at 100 or 30 per well in 48-well plates cultured media containing 10% fetal bovine serum (FBS). During initial plating, attached plate spread point attachment. This resulted monolayer cultures On day 4...

10.1530/jrf.0.0990577 article EN Reproduction 1993-11-01

Significance We show that mutations in HMGA2 affect fetal resource allocation, testis descent, and the size of pigs provides a target for gene modification can be used to modulate other mammalian species. This have implications agriculture as well development new strains companion animals. In addition, most xenograft pig donors adult organs larger than those humans. Recently, it has been shown regulation organ growth is donor-controlled, not host-controlled, resulting overgrowth damage after...

10.1073/pnas.1721630115 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2018-05-07

10.1016/j.anireprosci.2021.106840 article EN publisher-specific-oa Animal Reproduction Science 2021-09-06

Objectives were to evaluate the administration of an anti-gonadotropin releasing factor (GnRF) analog on suppression estrus, consistency feed intake, and growth performance in market gilts investigate impact physiological changes would have carcass characteristics fresh meat quality. Gonadotropin stimulates anterior pituitary release luteinizing hormone that acts ovary induce follicle development indirectly initiates ovulation. Improvest (Zoetis, Kalamazoo, MI) contains incomplete version...

10.2527/jas.2014-7756 article EN Journal of Animal Science 2014-08-23

Abstract Background Heat stress adversely affects pig growth and reproduction performance by reducing feed intake, weight gain, farrowing rate, litter size. tolerance is an important characteristic in pigs, allowing them to mitigate the negative effects of heat on their physiological activities. Yet, genetic variation signaling pathways associated with biological processes heat-tolerant pigs are currently not fully understood. This study examined differentially expressed genes constructed...

10.1186/s12863-020-00852-4 article EN cc-by BMC Genomic Data 2020-04-21
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