A5016610534- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Aquaculture Nutrition and Growth
- Inflammatory Bowel Disease
- Aquaculture disease management and microbiota
- Eosinophilic Esophagitis
- Protein Degradation and Inhibitors
- Microscopic Colitis
- Diagnosis and treatment of tuberculosis
- Renal Transplantation Outcomes and Treatments
- Chronic Lymphocytic Leukemia Research
- Biosimilars and Bioanalytical Methods
- Identification and Quantification in Food
- Aquatic life and conservation
- Hematological disorders and diagnostics
- Congenital Anomalies and Fetal Surgery
- Viral gastroenteritis research and epidemiology
- Organ Donation and Transplantation
- Plant Physiology and Cultivation Studies
- Collagen: Extraction and Characterization
- Hepatitis C virus research
- Invertebrate Immune Response Mechanisms
- Biochemical Analysis and Sensing Techniques
- Autoimmune and Inflammatory Disorders Research
- Plant Pathogens and Fungal Diseases
WinnMed
2021-2025
Jimei University
2023-2025
Mayo Clinic in Arizona
2013-2025
Fujian Fisheries Research Institute
2023-2025
Mayo Clinic
2008-2025
Mayo Clinic in Florida
2021-2024
Sichuan Agricultural University
2023-2024
Affiliated Hospital of Qingdao University
2023-2024
Qingdao University
2023-2024
Fudan University
2023-2024
Objective Random skin flaps have many applications in plastic and reconstructive surgeries. However, distal flap necrosis restricts wider clinical utility. Mitophagy, a vital form of autophagy for damaged mitochondria, is excessively activated ischemia/reperfusion (I/R) injury, thus inducing cell death. Aldehyde dehydrogenase-2 (ALDH2), an allosteric tetrameric enzyme, plays important role regulating mitophagy. We explored whether ALDH2 by N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide...
Temperature affects the metabolism of fish, and fish different sizes have tolerances to temperature. The aim this experiment was compare two juvenile spotted seabass, Lateolabrax maculatus (with average weights 57.91 ± 11.57 g 13.92 2.77 g, respectively) for changes in physiological, biochemical, molecular mechanisms under acute heat stress. Experimental were exposed temperature increasing from 23 °C 32 °C, mortality rate noted at various stress exposures (0, 3, 6, 12, 24, 48, 72 h)....
Abstract Background and Hypothesis Teclistamab, a novel bispecific monoclonal antibody targeting CD3 B-cell maturation antigen (BCMA), chimeric receptor T-cell (CAR-T) therapy are promising options for treating relapsed/refractory multiple myeloma (MM). However, the rates of acute kidney injury (AKI) associated with teclistamab remain inadequately characterized. This study aims to compare incidence, severity, outcomes AKI between patients receiving CAR-T therapy. Methods was retrospective...
TPS788 Background: MSLN is a desirable candidate for targeted therapy given its limited expression in normal tissues and overexpression several malignancies, including PANC, mesothelioma, non-small cell lung, ovarian cancers (TCGA 2022). MSLN-targeted CAR T T-cell receptor therapies have shown promising clinical activity; however, on-target, off-tumor toxicity, fatal events, occurred (1-3). Autologous logic-gated Tmod address the challenges of toxicity by combining 2 CARs: activating...
Outcomes of bispecific antibodies in patients with renal impairment (RI) are not well-characterized given the exclusion these from clinical trials. Herein, we evaluated relapsed/refractory multiple myeloma and RI treated standard-of-care teclistamab. was defined as creatinine clearance (CrCl) <40mL/min. CrCl <30mL/min or dialysis dependence were severe RI. Of 384 included patients, 81 (21%) had RI, including 45 (18%) 18 (5%) on dialysis. Patients more likely to be older (median...
Mulberry leaf extract (ELM) has the functions of promoting growth, antioxidant, improving intestinal microbial composition, thus providing a potential solution occurrence fish diseases. Therefore, this experiment was conducted to explore effects ELM on health spotted sea bass Lateolabrax maculatus . A total 360 (9.00 ± 0.02 g) were selected and randomly divided into 6 groups. Fish in each group given feed with varying concentration (0, 3, 6, 9, 12, 15 g/kg) for 52 days, respectively. Results...
Porphyra yezoensis polysaccharides (PPs) have biological activities such as promoting digestion, functioning antioxidants, and improving intestinal health. The aim of this study was to investigate the effects PPs on health spotted sea bass (Lateolabrax maculatus). A total 360 (10.53 ± 0.02 g) were randomly divided into six groups. Fish in each group fed with varying PP concentrations (0, 3, 6, 9, 12, 15 g/kg) for 52 days. results showed that 12 g/kg significantly increased body weight gain,...
The study investigated the impact of chlorogenic acid (CGA) supplementation in a high-fat diet (HFD) on growth, lipid metabolism, intestinal and hepatic histology, as well gut microbiota spotted sea bass. A total 540 fish were fed six experimental diets, including normal fat (NFD), (HFD), HFD supplemented with 100, 200, 300, 400 mg/kg CGA (named HFD1, HFD2, HFD3, HFD4, respectively) for 7 weeks. results showed that feeding increased growth deposition compared to NFD group. Inclusion 300...
Optimal preclosure fluid resuscitation in gastroschisis (GS) is unknown. The purpose of our study was to evaluate effects intravenous on GS outcome. Cases were accrued from a national database. Risk variables analyzed included gestational age (GA), birth weight (BW), neonatal illness severity score, and bolus administration within 6 hours intensive care unit admission. Outcomes closure success, days ventilation/total parenteral nutrition (TPN), bacteremic episodes. Linear logistic regression...
Patients with multiple myeloma (MM) who do not respond to initial therapy have worse outcomes than primary responders, and effective treatments are lacking in this population. However, the of refractory disease modern treatment era yet been studied. We reviewed patients MM treated triplet/quadruplet at our institution assess incidence impact salvage therapies identified 1127 patients, whom 1086 were evaluated for hematologic responses after 4 6 cycles. Of these, 93.3% (1013) had evidence...
Clostridium butyricum (CB) is known to promote growth, enhance immunity, digestion, and improve intestinal health. In this study, we investigated the effects of CB in feed on growth performance, health juvenile spotted sea bass. To provide a theoretical basis for development application bass, total 450 bass with an initial body weight (9.58 ± 0.05) g were randomly divided into six groups. Gradient levels 0, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% (1×109 cfu/g) supplemented diets, designated as CC, CB1,...
Laminarin has antioxidant and immunomodulatory properties favorably impacts gut microbial composition, providing a potential solution for the treatment of intestinal diseases in fish. The aim this study was to investigate effects laminarin on growth health juvenile spotted seabass, Lateolabrax maculatus . A total 450 juveniles (initial body weight: 7.14 ± 0.10 g) were randomly divided into 6 groups with 3 replicates per group 25 fish replicate. Six diets prepared supplementation at doses 0%...