A5018747324- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Cystic Fibrosis Research Advances
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Inflammatory Bowel Disease
- Multiple and Secondary Primary Cancers
- RNA modifications and cancer
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Botulinum Toxin and Related Neurological Disorders
- Virus-based gene therapy research
- Stroke Rehabilitation and Recovery
- Glioma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Trigeminal Neuralgia and Treatments
University of California, San Diego
2009-2025
The University of Texas Health Science Center at Houston
2023-2025
Moores Cancer Center
2017-2024
UC San Diego Health System
2017-2024
Yale University
2023
Royal Adelaide Hospital
2023
Loyola University Medical Center
2016-2022
Riverside University Health System - Medical Center
2022
St. George's University
2022
Desert Regional Medical Center
2022
Oncology rapidly shifted to telemedicine in response the COVID-19 pandemic. Telemedicine can increase access healthcare, but recent research has shown disparities exist with use during This study evaluated health associated uptake pandemic among cancer patients a tertiary care academic medical center.This retrospective cohort adult who received outpatient oncology within healthcare system between January and September 2020. We used multivariable mixed-effects logistic regression models...
Treatment of hematologic malignancies with patient-derived anti-CD19 chimeric antigen receptor (CAR) T-cells has demonstrated long-term remissions for patients otherwise treatment-refractory advanced leukemia and lymphoma. Conversely, CAR T-cell treatment solid tumors, including gastric cancer (GC), proven more challenging due to on-target off-tumor toxicities, poor tumor infiltration, inefficient expansion, immunosuppressive microenvironments, demanding preconditioning regimens. We report...
The NCCN Guidelines for Colorectal Cancer (CRC) Screening describe various colorectal screening modalities as well recommended schedules patients at average or increased risk of developing sporadic CRC. They are intended to aid physicians with clinical decision-making regarding CRC without defined genetic syndromes. These Insights focus on select recent updates the Guidelines, including a section primary and secondary prevention, provide context panel’s recommendations age which initiate in...
To date, evidence for tissue epidermal growth factor receptor (EGFR) overexpression as a biomarker anti-EGFR therapies has been weak. We investigated the genomic landscape of EGFR amplification in blood-derived cell-free tumor DNA (cfDNA) across diverse cancers and role achieving response.We assessed status among 28,584 patients with malignancies evaluated by clinical-grade next-generation sequencing (NGS) cfDNA (54- to 73-gene panel). Furthermore, we curated clinical characteristics 1,434...
TPS788 Background: MSLN is a desirable candidate for targeted therapy given its limited expression in normal tissues and overexpression several malignancies, including PANC, mesothelioma, non-small cell lung, ovarian cancers (TCGA 2022). MSLN-targeted CAR T T-cell receptor therapies have shown promising clinical activity; however, on-target, off-tumor toxicity, fatal events, occurred (1-3). Autologous logic-gated Tmod address the challenges of toxicity by combining 2 CARs: activating...
Small cell lung cancer (SCLC) transformation is one of the mechanisms drug resistance to tyrosine kinase inhibitors (TKIs) in advanced epidermal growth factor receptor (EGFR)-mutated non-small (NSCLC) and represents an increasingly recognized clinical dilemma.We performed a retrospective review 964 cases at University California, San Diego patients with EGFR sensitizing mutations. Nine had biopsy-confirmed small transformation. The unique gene alterations clinicopathologic features were...
Problem Women with a history of recurrent pregnancy losses ( RPL ) and unexplained infertility UI have high incidence preeclampsia PE other obstetrical complications. We aimed to investigate the complications in women or who were treated anti‐inflammatory anticoagulant treatment. Methods The medical records 72 delivered live born infant from January 2008 December 2009 (prednisone and/or intravenous immunoglobulin G) (low‐molecular‐weight heparin low‐dose aspirin) treatment reviewed...
Studies have demonstrated an association between quantity of circulating tumor DNA (ctDNA) and poorer survival. We investigated the relationship percent ctDNA (%ctDNA), total number alterations, overall survival (OS) in liquid biopsies.Overall, 418 patients with blood-based next-generation sequencing (54 to 73 genes) were analyzed. Eligible included those who had advanced/metastatic solid malignancies never received immunotherapy treatment, which may alter curve high mutational...
Abstract Background Deprescribing may benefit older frail patients experiencing polypharmacy. We investigated the scope for deprescribing in acutely hospitalised and long-term implications of continuation medications that could potentially be deprescribed. Methods Acutely (n = 170) discharged to Residential Aged Care Facilities, ≥75 years receiving ≥5 regular were assessed during admission determine eligibility key drug classes, along with actual incidence deprescribing. The impact nominated...
Rapid advances in the utility of molecular testing to identify common and uncommon driver mutations as well expeditious rate drug development have intensified need obtain multiplex next generation sequencing from tissue and/or blood at time diagnosis order determine most appropriate treatment for patients with advanced lung cancers. In this review, we discuss currently available investigational targeted therapies sensitizing epidermal growth factor receptor ( EGFR ) mutations, anaplastic...
Aim: Serotonin syndrome (SS) is a life-threatening that occurs with the use of serotonergic drugs, most commonly due to two or more agents. Cerebral palsy associated mood disorders, and pain, prevalence up 50-80%. Case presentation: A 58-year-old female cerebral palsy, metastatic malignancy disorder who presented emergency department acute-on-chronic signs SS. She was initiated on iv. dilaudid, titrated off oral medications scheduled for left-sided sacroiliac joint injection. Results: It...
Total neoadjuvant therapy (TNT) is the recommended treatment for locally advanced rectal cancer. The optimal sequence of TNT debated: induction (chemotherapy first) or consolidation (chemoradiation first)? We aim to evaluate practice patterns and clinical outcomes total with either regiments in United States patients Methods: This a retrospective analysis National Cancer Database stage II III cancer, diagnosed between 2006 2017, who underwent followed by surgery. Results: From we identified...
Abstract Concomitant mutations in KRAS and GNAS have been linked to mucinous histology gastrointestinal neoplasms of the appendix, colon, pancreas (IPMN). Upon progression, these tumors are characterized by metastasis which favors peritoneal surface, resulting carcinomatosis peritonei (MCP). Recently we described a novel technique allows for long term culture drug intervention human MCP ex-vivo. With evidence durable clinical benefit CDK4-6 inhibition single patient with chemo refractory...
Silver nitrate is a commonly used substance in the cauterization of traumatic soft tissue wounds to stop bleeding. As an inorganic compound with high density, silver very radiodense. We present case topical application on fingertip laceration 32-year-old diabetic woman, which was misinterpreted as heterotopic ossification. The appearance radiographic studies not widely known, can lead misdiagnosis, further unnecessary imaging, and inappropriate surgery.
Non-invasive scar management typically involves pressure therapy, hydration with silicones or moisturizers, and UV protection. Moisture loss from scars can lead to hypertrophic formation. Pressure therapy reduces blood flow, fibroblast activity, transforming growth factor beta 1 (TGF-β1) release. This study examined various moisturizers liquid silicone gel’s impact on microcirculation. 40 volunteers participated in a where superficial abrasions were created induce trans epidermal water...
<h3>Background</h3> Chimeric antigen receptor (CAR) T-cell therapy has been challenging in solid tumors due to an absence of tumor-specific targets and the resultant on-target, off-tumor toxicity. Tmod, a novel logic-gated CAR therapy, utilizes blocking discriminate tumor from normal cells, thus mitigating toxicity (figure 1).<sup>1 2</sup> The blocker recognizes human leukocyte (HLA), that is subject LOH.<sup>3 4</sup> Among advanced colorectal, pancreatic, non-small cell lung cancers, HLA...