A5101692002- Laser-Plasma Interactions and Diagnostics
- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- bioluminescence and chemiluminescence research
- Photoreceptor and optogenetics research
- Epigenetics and DNA Methylation
- Nicotinic Acetylcholine Receptors Study
- Magnetic confinement fusion research
- Atomic and Molecular Physics
- Histone Deacetylase Inhibitors Research
- Laser-Matter Interactions and Applications
- DNA and Nucleic Acid Chemistry
- Cancer Genomics and Diagnostics
- Bacterial Genetics and Biotechnology
- Advanced X-ray Imaging Techniques
- High-pressure geophysics and materials
- Biosensors and Analytical Detection
The University of Sydney
2018
University of Electro-Communications
2017-2018
University of California, Los Angeles
2006-2016
The concepts of matched-beam, self-guided laser propagation and ionization-induced injection have been combined to accelerate electrons up 1.45 GeV energy in a wakefield accelerator. From the spatial spectral content light exiting plasma, we infer that 60 fs, 110 TW pulse is guided excites wake over entire 1.3 cm length gas cell at densities below $1.5\ifmmode\times\else\texttimes\fi{}{10}^{18}\text{ }\text{ }{\mathrm{cm}}^{\ensuremath{-}3}$. High-energy are observed only when small (3%)...
Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor prognosis that lacks targeted therapies, especially in patients chemotherapy-resistant disease. Since DNA methylation-induced silencing of tumor suppressors common cancer, reversal promoter hypermethylation by 5-aza-2'-deoxycytidine (decitabine), an FDA-approved methyltransferase (DNMT) inhibitor, has proven effective treating hematological neoplasms. However, its antitumor effect varies solid tumors, stressing the...
Significance Transcription initiation by RNA polymerase (RNAP) is a highly regulated rate-limiting step in many genes and involves numerous intermediate states that remain incompletely understood. Here, we report the characterization of previously hypothesized slow pathway involving RNAP backtracking pausing. This backtracked paused state observed when all nucleoside triphosphates (NTPs) are present at physiologically relevant concentrations, but becomes more prevalent with unbalanced NTP...
An ultrarelativistic 28.5 GeV, 700-microm-long positron bunch is focused near the entrance of a 1.4-m-long plasma with density n(e) between approximately equal to 10(13) and 5 x 10(14) cm(-3). Partial neutralization space charge by mobile electrons results in reduction transverse size factor 3 high emittance plane beam 1 m downstream from exit. As increases, formation halo containing 40% total observed, indicating that focusing force nonlinear. Numerical simulations confirm these...
Abstract As a means of achieving highly sensitive bioluminescence imaging deep tissues utilizing the firefly luciferin-luciferase (L-L) reaction, we previously reported luciferin analogue, AkaLumine, which exhibits high cell-permeability and emits near-infrared (NIR) light with tissue-penetration by L-L reaction. However, while AkaLumine enables us to observe targets in tissues, its poor solubility aqueous media limits utility for vivo imaging. Herein, address this issue, have synthesized...
Positrons in the energy range of 3-30 MeV, produced by x rays emitted betatron motion a plasma wiggler 28.5 GeV electrons from SLAC accelerator, have been measured. The extremely high-strength is an ion column induced electron beam as it propagates through and ionizes dense lithium vapor. X 1-50 MeV forward cone angle 0.1 mrad collide with 1.7 mm thick tungsten target to produce electron-positron pairs. positron spectra are found be strongly influenced density length well bunch length. By...
Abstract Initiation is a highly regulated, rate-limiting step in transcription. We employed series of approaches to examine the kinetics RNA polymerase (RNAP) transcription initiation greater detail. Quenched assays, combination with magnetic tweezer experiments and other methods, showed that, contrary expectations, RNAP exit from later stages (e.g. 7-base transcript) was markedly slower than earlier stages. Further examination implicated previously unidentified intermediate which adopted...
When a highly relativistic electron is injected off-axis into an ion channel, the restoring force of radial field ions will cause to accelerate towards axis, overshoot, and begin undergo oscillations about ioncolumn axis at characteristic frequency; betatron frequency. This so-called motion radiate hard x-rays in forward direction. In two recent experiments Stanford Linear Accelerator Center (SLAC), 1-20kV range 1-50MV were produced with beam energy 28.5 GeV for densities 1 x 10<sup>14</sup>...
Summary form only given. Short, relativistic particle bunches propagating in plasmas drive large amplitude wakefields. These wakefields have longitudinal, accelerating and decelerating components, as well transverse, focusing defocusing components. When the bunch length is comparable to electron plasma wavelength of wake, electrons respond fields, ions are immobile. Plasma expelled from an bunch, while they attracted toward a positron bunch. This asymmetry leads important differences these...