A5063116305- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Axon Guidance and Neuronal Signaling
- Epilepsy research and treatment
- stochastic dynamics and bifurcation
- Photoreceptor and optogenetics research
- Neuroscience and Music Perception
- Neurological disorders and treatments
- Nonlinear Dynamics and Pattern Formation
University of Basel
2021-2025
Université Grenoble Alpes
2015-2022
Inserm
2015-2022
Grenoble Institute of Neurosciences
2015-2022
The brain faces the challenging task of preserving a consistent portrayal external world in face disruptive sensory inputs. What alterations occur representation amidst noise, and how does activity adapt to it? Although it has previously been shown that background white noise (WN) decreases responses salient sounds, mechanistic understanding processes responsible for such changes is lacking. We investigated effect WN on neuronal spiking activity, membrane potential, network oscillations...
During GABAergic synaptic transmission, G protein-coupled GABAB receptors (GBRs) activate K+ channels that prolong the duration of inhibitory postsynaptic potentials (IPSPs). We now show KCTD16, an auxiliary GBR subunit, anchors hyperpolarization-activated cyclic nucleotide-gated (HCN) containing HCN2/HCN3 subunits to GBRs. In dopamine neurons VTA (DAVTA neurons), this interaction facilitates activation HCN via hyperpolarization during IPSPs, counteracting GBR-mediated late phase these...
The epileptogenic processes leading to recurrent seizures in Genetic Epilepsies are largely unknown. Using the Absence Epilepsy Rat from Strasbourg, we investigated vivo network and single neuron mechanisms responsible for early emergence of epileptic activity. Local field potential recordings primary somatosensory cortex (SoCx), second post-natal week adulthood, showed that immature cortical discharges progressively evolved into typical spike-and-wave following a 3-step maturation process....
Absence epilepsy is characterized by the occurrence of spike-and-wave discharges concomitant with an alteration consciousness and associated cognitive comorbidities. In a genetic model absence in rat, rat from Strasbourg (GAERS), are shown to be initiated barrel field primary somatosensory cortex that codes whisker-related information, therefore playing essential role interactions rodents their environment. Sensory-information processing impaired epileptic GAERS, delayed sensory-evoked...
Epilepsy is one of the most important neurological diseases. It concerns about 1% population worldwide. Despite discovery new molecules, third epileptic patients are resistant to anti-epileptic drugs and among them only a few can benefit from resective surgery. In this context, radiotherapy an interesting alternative other treatments several clinical devices exist (e.g., Gamma Knife(®)). The European Synchrotron Radiation Facility offers possibility develop methods radiosurgery study their...
Absence epilepsy belongs to genetic epilepsies and is characterized by recurrent generalized seizures that are concomitant with alterations of consciousness associated cognitive comorbidities. Little known about the mechanisms leading occurrence epileptic (i.e. epileptogenesis) and, in particular, it remains an open question as whether neuronal hypersynchronization, a key feature seizure initiation, could result from aberrant structural connectivity within networks endowing them properties....
In this paper, we are going to localize the onset regions and investigate dynamics of absence epileptic seizures using local field potential recording by depth electrode. We assume that there some hidden states (under Markovian model) during seizure each spike is generated when one activated. Each state considered as linear superposition a few activities (substates) activity described two characteristics: 1) spatial topography 2) temporal representation. Experimental results demonstrate...
Epileptogenesis is the particular process during which epileptic network builds up progressively before onset of first seizures. Whether physiological functions are impacted by this development epilepsy remains unclear. To explore question, we used Genetic Absence Epilepsy Rats From Strasbourg (GAERS), in spike-and-wave discharges initiated whisker primary somatosensory cortex (wS1) and occur cortical maturation. We studied both wS1 circuits maturation to understand interactions between them...
Associative learning links sensory signals to their behavioral meaning by combining bottom-up inputs with top-down contextual information, enabling decision-making based on expected outcomes. It triggers plastic changes of neuronal responses in both excitatory and inhibitory cell populations. However, the role inhibition shaping this plasticity remains debated. Here we used chronic extracellular electrophysiology optogenetic manipulation neurons mice an auditory discrimination task. We found...