A5100354751- Photoacoustic and Ultrasonic Imaging
- Thermography and Photoacoustic Techniques
- Optical Imaging and Spectroscopy Techniques
- Ultrasound Imaging and Elastography
- Optical Coherence Tomography Applications
- Photonic and Optical Devices
- Plasmonic and Surface Plasmon Research
- Orbital Angular Momentum in Optics
- Ultrasonics and Acoustic Wave Propagation
- Advanced X-ray and CT Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Ultrasound and Hyperthermia Applications
- Atmospheric and Environmental Gas Dynamics
- Photodynamic Therapy Research Studies
California Institute of Technology
2023-2025
Nanjing University of Science and Technology
2020-2024
University of California, Irvine
2024
HKU-Pasteur Research Pole
2017
University of Hong Kong
2017
Transcranial photoacoustic computed tomography (PACT) holds significant potential as a neuroimaging modality. However, compensating for skull-induced aberrations in reconstructed images remains challenge. Although optimization-based image reconstruction methods (OBRMs) can account the relevant wave physics, they are computationally demanding and generally require accurate estimates of skull's viscoelastic parameters. To circumvent these issues, learning-based method was investigated...
Abstract Photoacoustic tomography (PAT) has emerged as a promising non-invasive imaging technology with significant potential for various clinical applications in medical settings. Traditionally, PAT utilizes single laser beam to generate the excitation light (Wang & Hu,2012). Nonetheless, this method often suffers from low signal-to-noise ratios (SNR) and poor image contrast due environmental noise other interfering factors. This paper introduces an interference technique designed focus...
Abstract Photoacoustic microscopy (PAM) is a novel non-invasive imaging technique that utilizes the endogenous optical absorption properties of sample to obtain structural and functional information about sample, has wide range applications in field bioimaging. However, there are few reports on position detection micrometallic materials using PAM. In this paper, method measure spatial metallic PAM proposed. Firstly, working principle realization introduced, experiments carried out copper...
Photoacoustic tomography holds tremendous potential for neuroimaging due to its functional magnetic resonance imaging (fMRI)-like contrast and greater specificity, richer contrast, portability, open platform, faster imaging, magnet-free quieter operation, lower cost. However, accounting the skull-induced acoustic distortion remains a long-standing challenge problem size. This is aggravated in where high accuracy needed detect minuscule changes. Here, we develop an solver based on...
Most photoacoustic computed tomography (PACT) systems usually ignore the anisotropy of tissue absorption coefficient, which will lead to lack information in reconstructed images. In this work, effect is addressed possible optical on PACT The functional relationship derived between response and polarization angle excitation light. An adaptive polarized light imaging (AP-PACT) approach proposed shown make up for achieve optimal image contrast when samples with anisotropic absorption, by...
Ultrafast ultrasound imaging using plane or diverging waves, instead of focused beams, has advanced greatly the development novel methods for evaluating tissue functions beyond anatomical information. However, sonographic signal-to-noise ratio (SNR) ultrafast remains limited due to lack transmission focusing, and thus insufficient acoustic energy delivery. We hereby propose a new methodology with cascaded dual-polarity waves (CDWs), which consists pulse train positive negative polarities. A...
Previously, we introduced photomagnetic imaging (PMI) that synergistically utilizes laser light to slightly elevate the tissue temperature and magnetic resonance thermometry (MRT) measure induced temperature. The MRT maps are then converted into absorption using a dedicated PMI image reconstruction algorithm. In maps, presence of abnormalities such as tumors would create notable high contrast due their higher hemoglobin levels. this study, present new artificial intelligence-based algorithm...
Geometric calibration of ultrasound transducer arrays is critical to optimizing the performance photoacoustic computed tomography (PACT) systems. We present a geometric method that applicable wide range PACT obtain speed sound and point source locations using surrogate methods, which results in linear problem coordinates. characterize estimation error, informs our choice arrangement. demonstrate three-dimensional system show improves contrast-to-noise ratio, size, spread reconstructions by...
In biomedical imaging, photoacoustic computed tomography (PACT) has recently gained increased interest as this imaging technique good optical contrast and depth of acoustic penetration. However, a spinning blur will be introduced during the image reconstruction process due to limited size ultrasonic transducers (UT) discontinuous measurement process. study, damping UT adaptive back-projection co-optimization (CODA) method is developed improve lateral spatial resolution PACT. our PACT system,...
In this paper, four rectangular slits with the same size and regular rotation angle are regarded as meta-atom, arranged on circular contours, to create plasmonic vortex lenses (PVLs) solely based geometric phase. These PVLs can achieve purpose of exciting surface plasmon polariton (SPP) vortices arbitrary combinations topological charge (TC) when illuminated by circularly polarized (CP) light different handedness traditional PVLs. Furthermore, they generate SPP TCs specific constant or...
Abstract Acoustic–plasmonic coupling in metallic nanoparticles can significantly alter their optical absorption and scattering characteristics. However, almost all previous investigations on acoustic–plasmonic so far have been focused the spectral response of particles a vacuum. In this report, spatial photon mode taking count individual gold nanoparticle (GN) silicon substrate under ultrasonic influence was presented. The is visualized with parametric images patterns particle excitation...
Light propagation wavefront and photon composition variations occur when the beam encounters acoustic waves, bringing mechanical chemical inhomogeneity-induced light-intensity modulation, while phase variations, which carry more information about acoustic-optical coupling in medium, are often overlooked. This paper investigates of light with propagating ultrasound polarization aberration optical wave induced by ultrasound. A model was developed to express variation ultrasound-induced (UIPA)....
Materials such as silicon, copper, gold, and aluminum exhibit strong absorption scattering characterization under short-pulsed laser irradiation. Due to the photoelastic effect thermoelastic relaxation, focal area may induce a local modulation in refractive index, which can be detected with intensity reflection coefficient perturbation. Normally, thermal causes weak index change is negligible, compared pressure-induced most photoacoustic analytical systems. In this study, we present...
Photoacoustic computed tomography (PACT) is emerging as a new technique for functional brain imaging, primarily due to its capabilities in label-free hemodynamic imaging. Despite potential, the transcranial application of PACT has encountered hurdles, such acoustic attenuations and distortions by skull limited light penetration through skull. To overcome these challenges, we have engineered system that features densely packed hemispherical ultrasonic transducer array with 3072 channels,...
Ultrafast ultrasound imaging using plane or diverging waves, not focused beams, has enabled quantitative assessment of biological tissue elasticity, kinematics, and hemodynamics beyond anatomical information in the past decade. However, its sonographic signal-to-noise ratio (SNR) penetration depth are limited by insufficient energy delivery under safety limits. We hereby propose a novel coding scheme apply it to ultrafast increase SNR without compromising spatial resolution frame rate. In...
In laser additive manufacturing, the optical absorption characteristics of particles play a fundamental role in its application. As non-destructive, high resolution, contrast test method, photoacoustic imaging uses endogenous sample for and obtains structural functional information sample. this paper, is utilized to conduct an experimental study on properties micro-sized copper balls. The results show that method can effectively map distribution micro-particles, which great importance...