Previously, we introduced photomagnetic imaging (PMI) that synergistically utilizes laser light to slightly elevate the tissue temperature and magnetic resonance thermometry (MRT) measure induced temperature. The MRT maps are then converted into absorption using a dedicated PMI image reconstruction algorithm. In maps, presence of abnormalities such as tumors would create notable high contrast due their higher hemoglobin levels. this study, present new artificial intelligence-based algorithm...

Difficulty in heating tumors with high spatial selectivity while protecting surrounding healthy tissues from thermal harm is a challenge for cancer photothermal treatment (PTT). To mitigate this problem, PTT mediated by agents (PTAs) has been established as potential therapeutic technique to boost and reduce damage tissues. Various gold nanoparticles (AuNP) have effectively utilized PTAs, mainly using strategies target cancerous tissue increase selective damage. Meanwhile, imaging can be...

Photo-magnetic imaging (PMI) is an emerging optical modality that showed great performance on providing absorption maps with high resolution and quantitative accuracy. As a multi-modality technology, PMI warms up the imaged object using near infrared laser while temperature variation measured magnetic resonance imaging. By probing tissue at multiple wavelengths, concentration of main chromophores such as oxy- deoxy-hemoglobin, lipid, water are obtained then used to derive functional...

Background and Objectives In photothermal therapy, cancerous tissue is treated by the heat generated from absorbed light energy. For effective parameters affecting induced temperature should be determined before treatment modeling increase in via numerical simulations. However, accurate simulations can only achieved when utilizing optical, thermal, physiological properties of tissue. Here, we propose a multi‐wavelength photo‐magnetic imaging (PMI) technique that provides quantitative...

Multiwavelength photo-magnetic imaging (PMI) is a novel combination of diffuse optics and magnetic resonance imaging, to the best our knowledge, that yields tissue chromophore concentration maps with high resolution quantitative accuracy. Here, we present first experimental results, obtained using spectrally constrained PMI image reconstruction method, where are directly recovered, unlike conventional two-step approach requires an intermediate step reconstructing wavelength-dependent...

Although diffuse optical tomography (DOT) is able to obtain valuable functional information, its routine use in clinic hampered by poor spatial resolution and quantitative accuracy. Previously, our team introduced Photo-Magnetic Imaging (PMI) overcome the limitation of DOT. PMI a hybrid modality that synergistically utilizes optics Magnetic Resonance (MRI). While illuminating imaged medium near-infrared laser, induced internal temperature increase measured using Thermometry (MRT). Using...

Photo-magnetic imaging (PMI) is a novel diffuse optical technique used to recover high resolution images of the absorption coefficient bio-tissue. It uses near-infrared laser light slightly warm up tissue and measures induced temperature using magnetic resonance thermometry (MRT). The measured maps are then converted into dedicated PMI image reconstruction algorithm. We present convolutional neural network -based algorithm that improves accuracy recovered while reducing recovery time. This...

Photomagnetic imaging (PMI) employs near-infrared light to irradiate tissue and measures the induced temperature using MR thermometry (MRT). The MRT maps are then converted into absorption a dedicated reconstruction algorithm. Here, we present an AI-based method directly detect tumor boundaries from these use them as soft-a-priori in standard PMI Tests on phantoms showed nine-fold image acceleration, reducing artifacts by 15%, error ~2%.

We propose the proof-of-concept of a novel method for wide-field spectrally resolved near-infrared fluorescence (NIRF) imaging using wavelength-swept laser. The performance our is evaluated on biotissue-like phantom bearing two inclusions, one filled with indocyanine green (ICG) dissolved in distilled water and second dimethyl sulfoxide (DMSO). A laser covering wavelengths around peak absorption ICG was used. difference spectra these solutions gives rise to an additional spectral contrast....

Tomographically recovering chromophore concentrations usually requires the intermediate step of reconstructing absorption maps at different wavelengths first. Here, we present a method that allows to obtain these directly from measured magnetic resonance temperature maps.

High scattering in biological tissues severely degrades the spatial resolution of optical fluorescence imaging thick tissue. As one most sensitive vivo molecular modalities, Fluorescence Tomography plays an essential role preclinical studies. To overcome limitations FT, we introduced a novel method termed, temperature modulated tomography (TMFT). TMFT is based on two key elements: 1) fluorescent agent (ThermoDots) and 2) high intensity focused ultrasound (HIFU). localizes position ThermoDots...

In photothermal therapy, heat generated from absorbed light energy is used to treat cancerous tissue. Thus, determining laser parameters that control temperature elevation prior therapy crucial for an effective outcome. These can be defined by modeling the expected increase via numerical simulations. The quality of these simulations highly depends on accurate knowledge optical properties treated Multi-wavelength Photo Magnetic Imaging (PMI) utilizes four wavelengths near infrared (NIR)...

Photo-Magnetic Imaging (PMI) is a novel multimodality imaging technique that provides optical absorption maps with high-resolution and quantitative accuracy. Here, we present the preliminary experimental validation results obtained using our new multi-wavelength PMI system.

We previously introduced Photo-Magnetic Imaging (PMI) as a true multi-modality imaging technique for non-invasive, high resolution optical tomography. With simple add-on of continuous wave lasers to an existing MRI system, PMI converts the laser induced temperature increase measured by MR thermometry into tissue absorption map utilizing dedicated Finite Element Model (FEM) based image reconstruction algorithm. The newly implemented multi-wavelength capabilities allow recover 3D oxygenation...

Difficulty in heating tumors with high spatial selectivity while protecting surrounding healthy tissues from thermal harm is a challenge for photothermal treatment (PTT) of cancer. To mitigate this problem, PTT mediated by agents (PTAs) has been established as potential therapeutic technique to boost and reduce damage tissues. A variety gold nanoparticles (AuNP) effectively utilized PTAs, particularly using strategies target cancerous tissue increase the selective damage. Meanwhile, imaging...