Sen Yu

ORCID: 0000-0003-0291-663X
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About
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Research Areas
  • Titanium Alloys Microstructure and Properties
  • Orthopaedic implants and arthroplasty
  • Bone Tissue Engineering Materials
  • Magnesium Alloys: Properties and Applications
  • Metal and Thin Film Mechanics
  • Advanced materials and composites
  • Additive Manufacturing Materials and Processes
  • Aluminum Alloys Composites Properties
  • Metallurgy and Material Forming
  • Corrosion Behavior and Inhibition
  • Intermetallics and Advanced Alloy Properties
  • High Entropy Alloys Studies
  • Microstructure and mechanical properties
  • Pain Mechanisms and Treatments
  • Hydrogen embrittlement and corrosion behaviors in metals
  • Electrocatalysts for Energy Conversion
  • Advanced Welding Techniques Analysis
  • Dental Implant Techniques and Outcomes
  • Nanoporous metals and alloys
  • Nuclear Materials and Properties
  • Anesthesia and Pain Management
  • Ion-surface interactions and analysis
  • Pain Management and Opioid Use
  • Advanced Photocatalysis Techniques
  • Additive Manufacturing and 3D Printing Technologies

Nanjing Foreign Language School
2025

Northwest Institute For Non-Ferrous Metal Research
2015-2024

Southern Medical University
2024

Air Force Medical University
2024

Beijing Institute of Technology
2024

Nanyang Technological University
2024

Viva Biotech (China)
2023

East China Jiaotong University
2021-2022

Xi'an Jiaotong University
2019-2022

China XD Group (China)
2018-2020

Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect HA nanoparticles (n-HA) against various cancer cells was reported. This study aimed at assessing the translational value n-HA both as bone-regenerating material and an antitumor agent. Inhibition tumor growth, prevention metastasis, enhancement survival rate tumor-bearing rabbits treated with were demonstrated. Activated mitochondrial-dependent...

10.1126/sciadv.aax6946 article EN cc-by-nc Science Advances 2019-08-02

Endowing implant surfaces with combined antibacterial and osteogenic properties by drug-loaded coatings has made great strides, but how to achieve the excellence of infection-triggered bactericidal in vivo-proven activities without causing bacterial resistance still remains a formidable challenge. Herein, antimicrobial peptides (AMPs) fragments were designed complexed on surface silver nanoparticle (AgNP) through hydrogen bonding, collagen structure-bionic silk fibroin (SF) was applied carry...

10.1016/j.bioactmat.2022.05.015 article EN cc-by Bioactive Materials 2022-05-20

Abstract Tantalum (Ta) metal is receiving increasing interest as biomaterial for load-bearing orthopedic applications and the synthetic properties of Ta can be tailored by altering its grain structures. This study evaluates capability sliding friction treatment (SFT) technique to modulate comprehensive performances pure Ta. Specifically, novel nanocrystalline (NC) surface with extremely small grains (average size ≤20 nm) was fabricated on conventional coarse-grained (CG) SFT. It shows that...

10.1038/srep40868 article EN cc-by Scientific Reports 2017-01-13

A two-step electrochemical surface treatment has been developed to modify the CP Ti on commercially pure titanium grade 2 (CP Ti): (1) anodic oxidation form TiO2 nanotube precoatings loaded with silver (Ag) and (2) microarc (MAO) produce a porous Ca-P-Ag coating in an electrolyte containing Ag, Ca, P. One-step MAO same also used coatings without preloaded Ag as control. Surface morphologies alloying chemistry of two were characterized by SEM, EDS, XPS. Biocompatibility antimicrobial...

10.1021/acsami.0c10032 article EN ACS Applied Materials & Interfaces 2020-09-11

Tuberculosis (TB) is a major global infectious disease. The challenges faced in current treatment often include the development of drug resistance, long periods and serious side effects. At same time, Nanotechnology offers innovative solutions to enhance TB treatment. With help nanoparticles such as liposomes, polymeric inorganic nanoparticles, delivery system can be improved, which leads higher concentrations drugs at site infection. In this way, effects are minimized time potentially shortened.

10.54254/2753-8818/2024.19861 article EN cc-by Theoretical and Natural Science 2025-01-09

In this study, on the surface of Mg–Sr alloy, we prepared two layer coatings, Ta2O5 primary MAO (Micro-arc oxidation) coating, and finally obtain a MAO/Ta2O5 composite coating by sol–gel method. The morphology, chemical composition microstructure coated uncoated alloy were characterized SEM, EDS, XPS XRD. corrosion resistance all samples was evaluated electrochemical hydrogen evolution tests. Its biocompatibility tested in vitro cell assay. It found that presented good resistance, current...

10.1016/j.jmrt.2022.08.132 article EN cc-by-nc-nd Journal of Materials Research and Technology 2022-09-01

Magnesium (Mg) and its alloys have been intensively studied to develop the next generation of bone implants recently, but their clinical application is restricted by rapid degradation unsatisfied osteogenic effect in vivo. A bioactive chemical conversion Mg-phenolic networks complex coating (eEGCG) was stepwise incorporated epigallocatechin-3-gallate (EGCG) exogenous Mg2+ on Mg-2Zn magnesium alloy. Simplex EGCG induced (cEGCG) set as compare group. The vitro corrosion behavior alloy, cEGCG...

10.1016/j.jma.2022.03.010 article EN cc-by-nc-nd Journal of Magnesium and Alloys 2022-05-19

Magnesium (Mg) and its alloys have been widely investigated as the most promising biodegradable metals for orthopedic device applications, but surface properties should be further improved to overcome restricted osteogenesis fast degradation problems.

10.1039/d0bm01584a article EN Biomaterials Science 2020-11-19

A process to dealloy a Ti-3Zr-2Sn-3Mo-25Nb (TLM) titanium alloy create porous surface structure has been reported in this paper aiming enhance the bioactivity of alloy. simple nanoporous topography on was produced through dealloying as-solution treated TLM In contrast, as-cold rolled created hierarchical micro/nanoporous topography. SEM and XPS were performed characterize element chemistry both structures. The roughness, hydrophilicity, protein adsorption, cell adhesion, proliferation,...

10.1021/acsami.1c02140 article EN ACS Applied Materials & Interfaces 2021-03-25

Introduction: Behaviors of swimming rodents are not uniform, exhibiting large variations, which may underlie the individual differences in exercise-induced benefits. The study aimed to monitor individualized behavior and evaluate its biological significance. Methods: A tank can rodent during exercise was established. total 45 mice were subjected training for 1 month (1 h per day) behaviors each mouse recorded. Results: displayed considerable variations aspects distance, velocity, area...

10.3389/fphys.2024.1357120 article EN cc-by Frontiers in Physiology 2024-02-26

Titanium alloys are some of the most important orthopedic implant materials currently available. However, their lack bioactivity and osteoinductivity limits osseointegration properties, resulting in suboptimal between titanium alloy bone interfaces. In this study, we used a novel sandblasting surface modification process to manufacture with bioactive sandblasted surfaces systematically characterized morphology physicochemical properties. We also analyzed evaluated interfaces by vitro...

10.3389/fbioe.2023.1251947 article EN cc-by Frontiers in Bioengineering and Biotechnology 2023-08-21

The microstructure and biodegradability of a near β Ti–25Nb–3Zr–3Mo–2Sn alloy produced by laser engineered net shaping have been compared to those alloys via casting cold rolling in order identify the key effects processing pathways on development biocorrosion properties. Results confirm significant influence technique concomitant biocompatibility alloy. Tests using mesenchymal stem cells ability additively manufactured support cell adhesion spreading.

10.1021/acsbiomaterials.9b00596 article EN ACS Biomaterials Science & Engineering 2019-10-03
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