A5027548306- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Titanium Alloys Microstructure and Properties
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Cell Adhesion Molecules Research
- Hernia repair and management
- 3D Printing in Biomedical Research
- Calcium Carbonate Crystallization and Inhibition
- Orthopedic Infections and Treatments
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Plasma Applications and Diagnostics
- Pelvic and Acetabular Injuries
- Periodontal Regeneration and Treatments
- Metal and Thin Film Mechanics
- Peptidase Inhibition and Analysis
- Wound Healing and Treatments
- Collagen: Extraction and Characterization
- Angiogenesis and VEGF in Cancer
- Bone Metabolism and Diseases
- Protease and Inhibitor Mechanisms
- Bone and Dental Protein Studies
- Advanced Fluorescence Microscopy Techniques
- Surgical Sutures and Adhesives
Universitat Politècnica de Catalunya
2015-2024
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2014-2024
Instituto de Salud Carlos III
2024
University of Washington
2024
Institut de Recerca Sant Joan de Déu
2022-2023
Research Network (United States)
2014
Bioengineering (Switzerland)
2014
Vall d'Hebron Institut de Recerca
2008-2011
Universitat Autònoma de Barcelona
2008-2011
Some biomaterials are osteoinductive, that is, they able to trigger the osteogenic process by inducing differentiation of mesenchymal stem cells lineage. Although underlying mechanism is still unclear, microporosity and specific surface area (SSA) have been identified as critical factors in material-associated osteoinduction. However, only sintered ceramics, which a limited range porosities SSA, analyzed so far. In this work, we were extend these ranges nanoscale, through foaming 3D-printing...
A new self-setting ceramic ink was developed for robocasting of biomimetic hydroxyapatite scaffolds, based on alpha-tricalcium phosphate and gelatine. After setting a is obtained, with higher reactivity resorbability than high-temperature sintered hydroxyapatite. The reaction the results in significant increase mechanical properties scaffolds.
Bone apatite consists of carbonated calcium-deficient hydroxyapatite (CDHA) nanocrystals. Biomimetic routes allow fabricating synthetic bone grafts that mimic biological apatite. In this work, we explored the role two distinctive features biomimetic apatites, namely, nanocrystal morphology (plate vs needle-like crystals) and carbonate content, on regeneration potential CDHA scaffolds in an vivo canine model. Both ectopic formation scaffold degradation were drastically affected by after...
Abstract Multispectral imaging is an established method to extend the number of colours usable in fluorescence beyond typical limit three or four, but standard approaches are poorly suited live-cell imaging. We introduce approach for multispectral live cells, comprising iterative spectral unmixing algorithm and eight channel camera-based image acquisition hardware. This enables accurate low signal-to-noise ratio datasets, imaging, captured at video rates. use this on a commercial spinning...
The fabrication of calcium phosphates using biomimetic routes, namely, precipitation processes at body temperature, results in distinct features compared to conventional sintered phosphate ceramics, such as a high specific surface area (SSA) and micro- or nanometric crystal size. aim this article is analyze the effects these parameters on cell response, focusing two bone types: rat mesenchymal stem cells (rMSCs) human osteoblastic (SaOS-2). Biomimetic calcium-deficient hydroxyapatite (CDHA)...
Abstract Objectives Surface modifications performed at the neck of dental implants, in manner micro‐grooved surfaces, can reduce fibrous tissue encapsulation and prevent bacterial colonization, thereby improving fibrointegration formation a biological seal. However, applied procedures are technically complex and/or time consuming methods. The aim this study was to analyse fibroblast behaviour on modified titanium surfaces obtained, applying simple low‐cost method. Material methods An array...
Although it is widely acknowledged that ionic substitutions on bulk hydroxyapatite substrates have a strong impact their biological performance, little known of effect nanoparticles (NPs) especially when used for gene transfection or drug delivery. The fact NPs would be internalized poses many questions but also opens up new possibilities. objective the present work to synthesize and assess series hydroxyapatite-like (HA) doped with various ions cell behavior, i.e. carbonate, magnesium...
Since metallic biomaterials used for bone replacement possess low bioactivity, the use of cell adhesive moieties is a common strategy to improve cellular response onto these surfaces. In recent years, recombinant proteins has emerged as an alternative native and short peptides owing fact that they retain biological potency proteins, while improving their stability. present study, we investigated effect two different fragments fibronectin, spanning 8-10th 12-14th type III repeats, covalently...
A lack of primary stability and osteointegration in metallic implants may result implant loosening failure. Adding porosity to reduces the stress shielding effect improves performance, allowing surrounding bone tissue grow into scaffold. However, a bioactive surface is needed stimulate improve mechanical stability. In this study, porous titanium were produced via powder sintering create different diameters open interconnectivity. Two strategies used generate on foams: (1) an inorganic alkali...
Abstract The formation of a biological seal around the neck titanium (Ti) implants is critical for ensuring integration at gingival site and preventing bacterial colonization that may lead to periimplantitis. This process guided by activated fibroblasts, named myofibroblasts, which secrete extracellular matrix (ECM) proteins ECM‐degrading enzymes resolving wound. However, in some cases, Ti not able attract activate fibroblasts sufficient extent, compromise success implant. Fibronectin (FN)...
Abstract Immobilization of bioactive peptide sequences on CoCr surfaces is an effective route to improve endothelialization, which great interest for cardiovascular stents. In this work, we explored the effect physical and covalent immoblization RGDS, YIGSR their equimolar combination peptides endothelial cells (EC) smooth muscle cell (SMC) adhesion thrombogenicity. We extensively investigated using RT‐qPCR, expression by ECs cultured functionalised different genes. Genes relevant (ICAM‐1...
Titanium (Ti) and Ti alloys have been used for decades bone prostheses due to its mechanical reliability good biocompatibility. However, the high stiffness of implants lack bioactivity are pending issues that should be improved minimize implant failure. The stress shielding effect, a result mismatch between titanium bone, can reduced by introducing tailored structural porosity in implant. In this work, porous structures were produced direct ink writing (DIW), using new formulation containing...