A5037293169- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Calcium Carbonate Crystallization and Inhibition
- Dental Implant Techniques and Outcomes
- Osteoarthritis Treatment and Mechanisms
- Angiogenesis and VEGF in Cancer
- Bone and Dental Protein Studies
- Bacterial biofilms and quorum sensing
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Bone fractures and treatments
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- Synthesis and Characterization of Heterocyclic Compounds
- Antimicrobial Peptides and Activities
- Neonatal Respiratory Health Research
- Cardiac and Coronary Surgery Techniques
- bioluminescence and chemiluminescence research
- Cell Adhesion Molecules Research
- Advanced Proteomics Techniques and Applications
- Synthesis and biological activity
University of Medicine and Health Sciences
2025
Royal College of Surgeons in Ireland
2020-2024
Universitat Politècnica de Catalunya
2017-2024
Advanced Materials and BioEngineering Research
2022-2024
Trinity College Dublin
2021-2024
West Pomeranian University of Technology
2024
Polish Academy of Sciences
2009
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2009
Dalhousie University
1990-1991
Some biomaterials are osteoinductive, that is, they able to trigger the osteogenic process by inducing differentiation of mesenchymal stem cells lineage. Although underlying mechanism is still unclear, microporosity and specific surface area (SSA) have been identified as critical factors in material-associated osteoinduction. However, only sintered ceramics, which a limited range porosities SSA, analyzed so far. In this work, we were extend these ranges nanoscale, through foaming 3D-printing...
Damaged or diseased bone can be treated using autografts a range of different grafting biomaterials, however limitations with such approaches has motivated increased interest in developmentally inspired tissue engineering (BTE) strategies that seek to recapitulate the process endochondral ossification (EO) as means regenerating critically sized defects. The clinical translation will require scaled-up, geometrically defined hypertrophic cartilage grafts rapidly vascularised and remodelled...
Human mesenchymal stromal cells (hMSCs) seeded on calcium phosphate (CaP) bioceramics are extensively explored in bone tissue engineering and have recently shown effective clinical outcomes. In previous pre-clinical studies, hMSCs-CaP-mediated formation was preceded by osteoclastogenesis at the implantation site. The current study evaluates to what extent phase composition of CaPs affects osteoclast response ultimately influence formation. To this end, four different CaP were used,...
Bone apatite consists of carbonated calcium-deficient hydroxyapatite (CDHA) nanocrystals. Biomimetic routes allow fabricating synthetic bone grafts that mimic biological apatite. In this work, we explored the role two distinctive features biomimetic apatites, namely, nanocrystal morphology (plate vs needle-like crystals) and carbonate content, on regeneration potential CDHA scaffolds in an vivo canine model. Both ectopic formation scaffold degradation were drastically affected by after...
Treating bone infections and ensuring repair is one of the greatest global challenges modern orthopedics, made complex by antimicrobial resistance (AMR) risks due to long-term antibiotic treatment debilitating large defects following infected tissue removal. An ideal multi-faceted solution would will eradicate bacterial infection without use, simultaneously stimulating osteogenesis angiogenesis. Here, a multifunctional collagen-based scaffold that addresses these needs leveraging potential...
The present work aims to develop optimized scaffolds for bone repair by incorporating mesoporous nanoparticles into them, thereby combining bioactive factors cell growth and preventing rapid release or loss of effectiveness. We synthesized biocompatible biodegradable designed the controlled codelivery curcumin (CUR) recombinant human morphogenic protein-2 (rhBMP-2). Active agents in dendritic silica/titania (DSTNs) were incorporated at different weight percentages (0, 2, 5, 7, 9, 10 wt %) a...
The fabrication of calcium phosphates using biomimetic routes, namely, precipitation processes at body temperature, results in distinct features compared to conventional sintered phosphate ceramics, such as a high specific surface area (SSA) and micro- or nanometric crystal size. aim this article is analyze the effects these parameters on cell response, focusing two bone types: rat mesenchymal stem cells (rMSCs) human osteoblastic (SaOS-2). Biomimetic calcium-deficient hydroxyapatite (CDHA)...
Very large bone defects significantly diminish the vascular, blood, and nutrient supply to injured site, reducing bone's ability self-regenerate complicating treatment. Delivering nanomedicines from biomaterial scaffolds that induce host cells produce bone-healing proteins is emerging as an appealing solution for treating these challenging defects. In this context, microRNA-26a mimics (miR-26a) are particularly interesting they target two most relevant processes in regeneration-angiogenesis...
Abstract Osteomyelitis, a severe bone infection, is an extremely challenging complication in the repair of traumatic defects. Furthermore, use long-term high-dose antibiotics standard treatment increases risks antibiotic resistance. Herein, antibiotic-free, collagen silver-doped hydroxyapatite (coll-AgHA) scaffold reinforced with 3D printed polycaprolactone (PCL) framework was developed enhanced mechanical properties to be used load-bearing defects antimicrobial as preventative measure...
Since the discovery that nanostructured surfaces were able to kill bacteria, many works have been published focusing on design of nanopatterned with antimicrobial properties. Synthetic bone grafts, based calcium phosphate (CaP) formulations, can greatly benefit from this if adequate nanotopographies be developed. However, CaP are reactive materials and experience ionic exchanges when placed into aqueous solutions which may in turn affect cell behaviour complicate interpretation bactericidal...
Core-shell scaffolds offer a promising regenerative solution to debilitating injuries anterior cruciate ligament (ACL) thanks unique biphasic structure. Nevertheless, current core-shell designs are impaired by an imbalance between permeability, biochemical and mechanical cues. This study aimed address this issue creating porous construct which favors cell infiltration matrix production, while providing stability at the site of injury. The developed scaffold combines outer shell electrospun...
Calcium phosphate (CaP) substrates are successfully used as bone grafts due to their osteogenic properties. However, the influence of physicochemical features CaPs in angiogenesis is frequently neglected despite it being a crucial process for regeneration. The present work focuses on analyzing effects textural parameters biomimetic calcium deficient hydroxyapatite (CDHA) and sintered beta-tricalcium (β-TCP), such specific surface area, roughness, microstructure, behavior rat endothelial...
Bone morphogenetic proteins (BMPs) have been widely investigated for treating non-healing fractures. They participate in bone reconstruction by inducing osteoblast differentiation, and osteoid matrix production. 1 The human recombinant protein of BMP-7 was among the first growth factors approved clinical use. Despite achieving comparable results to autologous grafting, severe side effects associated with its 2 Furthermore, removed from market. 3 These complications are related high doses...
The research has demonstrated the antimicrobial properties of plasma urging incorporation cold atmospheric (CAP) decontamination in current clinical therapies with aim to improve benefits on patients and society.
Whilst bone possesses an inherent capacity for regeneration, defects above a critical size cannot heal on their own. Damaged or diseased can be treated using autografts range of different grafting biomaterials, however limitations with such approaches has motivated increased interest in developmentally inspired tissue engineering (BTE) strategies that seek to recapitulate the process endochondral ossification (EO) as means regenerating critically sized defects. The clinical translation will...
Cyclophosphamide (CPAm) is a widely used chemotherapeutic agent that exhibits potent anti-cancer properties but often associated with debilitating side effects. Despite its efficacy, the management of CPAm-induced toxicities remains significant clinical challenge. There has been growing interest in exploring complementary and alternative therapies to mitigate these adverse effects recent years, this may be chance for earthworm-derived preparation, Venetin-1. Its rich composition bioactive...