A5085348528- Acute Myeloid Leukemia Research
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Prostate Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Urinary and Genital Oncology Studies
- Acute Lymphoblastic Leukemia research
- Prostate Cancer Treatment and Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Renal and related cancers
- Urological Disorders and Treatments
- Tumors and Oncological Cases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Trauma and Emergency Care Studies
The University of Texas MD Anderson Cancer Center
2019-2025
Scripps MD Anderson Cancer Center
2023
Aga Khan University Hospital
2023
Tecnológico de Monterrey
2023
Cancer Research And Biostatistics
2020
The University of Texas Health Science Center at Houston
2017-2019
University of Pittsburgh
2005
Western Pennsylvania Hospital
2005
University of Iowa
2005
Seattle University
2005
15 Background: Metastasis-directed therapy (MDT) for omPC has demonstrated progression-free survival (PFS) benefit in multiple phase 2 randomized clinical trials (RCTs) yet fallen short of demonstrating later endpoints. The X-MET collaboration amalgamates IPD from RCTs investigating oligometastatic cancers, incorporating new when published. Within X-MET, WOLVERINE combined all published MDT RCTs. Methods: Trial search identified 5 and standard care (SOC) vs. SOC alone: STOMP (NCT01558427),...
TP53 mutations are associated with poor outcomes in acute myeloid leukemia (AML). The prognostic impact of mutant (TP53mut) variant allelic frequency (VAF) is not well established, nor how this information might guide optimal frontline therapy. We retrospectively analyzed 202 patients newly diagnosed TP53-mutated AML who underwent first-line therapy either a cytarabine- or hypomethylating agent (HMA)-based regimen. By multivariate analysis, TP53mut VAF >40% was independently significantly...
OBJECTIVE Posttraumatic hydrocephalus (PTH) affects 11.9%-36% of patients undergoing decompressive craniectomy (DC) and is an important cause morbidity after traumatic brain injury (TBI). Early diagnosis treatment PTH can prevent further neurological compromise in who are recovering from TBI. There limited data on predictors shunting for DC METHODS Prospectively collected the erythropoietin severe TBI randomized controlled trial were studied. Demographic, clinical, imaging analyzed enrolled...
Abstract Purpose: Prognostic uncertainty is a major challenge for cancer of unknown primary (CUP). Current models limit meaningful patient-provider dialogue. We aimed to establish nomogram predicting overall survival (OS) in CUP based on robust clinicopathologic prognostic factors. Experimental Design: evaluated 521 patients with at MD Anderson Cancer Center (MDACC; Houston, TX; 2012–2016). Baseline variables were analyzed using Cox regression and developed significant predictors. Predictive...
Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. We considered that women PTB and placental evidence of malperfusion would be particularly affected.Pregnancy cohort study.Pittsburgh, PA, USA.Women (n = 115) term births 210) evaluated 4-12 years after pregnancy.Cardiometabolic risk markers were compared in prior versus births; pre-eclampsia growth restriction cases excluded. Placental vascular (vasculopathy, infarct, advanced villous maturation, perivillous...
Background: The optimal surveillance strategy after resection of colorectal liver metastases (CLM) is unknown. We evaluated changes in recurrence risk CLM and developed a algorithm. Methods: Patients undergoing during 1998 to 2015 were identified from prospectively compiled database analyzed if they had the potential for follow-up longer than longest observed time this cohort. Changes factors evaluated. All statistical tests 2-sided. Results: Among 2,105 patients who initially underwent...
Abstract Background Most current models for predicting survival after resection of colorectal liver metastasis include largest diameter and number metastases as dichotomous variables, resulting in underestimation the extent risk variation substantial loss statistical power. The aim this study was to develop validate a new prognostic model patients undergoing including continuous variables. Methods A developed using data from who underwent at MD Anderson Cancer Center had RAS mutational data....
Abstract Background Carbapenem resistance in non-carbapenemase producing Enterobacterales is thought to be mediated by increased beta-lactamase production and outer membrane porin mutations. Cases of phenotypic discordance carbapenem susceptibility (ertapenem-nonsusceptible, meropenem-susceptible) are documented. Given limited clinical data immunocompromised patients, we aim characterize risk factors that may lead carbapenem-discordant (CD-E) bloodstream infection (BSI) patients with cancer....
TPS614 Background: Complete response (CR) is a rare event in advanced clear cell renal carcinoma (ccRCC). The combination of nivolumab plus cabozantinib was recently approved for first-line treatment ccRCC, demonstrating improved progression-free survival (PFS) and objective rate (ORR) comparison to sunitinib. However, CR only 9%. Drugs that could synergize with T anti-tumor activity can improve rates. Radiation-induced DNA damage activate the cGAS-STING pathway promising mechanism. 177...
ABSTRACT Background and Objectives Fatty pancreas (FP), traditionally perceived as a benign finding, has been undergoing scrutiny lately due to growing evidence linking it various disease states, including increased risk for pancreatic cancer (PC). Methods A retrospective study of patients who underwent EUS at single institution from August 2007 October 2023, conducted by one endosonographer with more than 25 years experience. Focusing on individuals identified FP during EUS, we compared...
Abstract In relapsed/refractory acute myeloid leukemia (AML), the prognostic impact of complete remission (CR) and measurable residual disease (MRD) negativity is not well established. We retrospectively analyzed 141 patients with AML who received first salvage therapy had MRD assessed by multiparameter flow cytometry at time response. Patients achieved CR full hematologic recovery as best response vs those incomplete hematology lower cumulative incidence relapse (P = .01) better...
Abstract FLT3 -ITD mutations in newly diagnosed acute myeloid leukemia (AML) are associated with worse overall survival (OS). diversity can further influence clinical outcomes. Addition of inhibitors to standard chemotherapy has improved OS. The aim this study is evaluate the prognostic impact and identify predictors efficacy inhibitors. We reviewed prospectively collected data from 395 patients mutant AML. 156 (39%) received combined either high or low intensity chemotherapy. There was no...
ObjectiveSmall bowel adenocarcinoma (SBA) is a rare malignancy with limited evidence regarding outcomes after curative resection of localised disease. We aimed to evaluate presentation and prognostic factors affecting overall survival (OS), relapse-free (RFS) recurrence SBA.MethodsConsecutive patients completely resected SBA (1979–2019) were retrospectively reviewed for presentation, patient tumour characteristics, perioperative treatment, recurrence, outcomes, factors.ResultsAmong 257 total...
Abstract Real-world evidence regarding the value of integrating genomic profiling (GP) in managing cancer unknown primary (CUP) is limited. We assessed this clinical utility using a prospective trial 158 patients with CUP (October 2016-September 2019) who underwent GP next-generation sequencing designed to identify alterations (GAs). Only 61 (38.6%) had sufficient tissue for successful profiling. GAs were seen 55 (90.2%) which US Food and Drug Administration–approved genomically matched...
616 Background: The optimal therapy sequencing in aUC with FGFR2/3 alt is unclear. FGFR inhibition may increase Nectin-4 expression. We hypothesized that outcomes EV would be more favorable when given after E compared to before pts harboring genomic alt. Methods: Pts alts who received only (EVo), then (E->EV), or (EV->E) were included. Overall survival (OS) measured from start (based on agent first) and progression-free (PFS) assessed KM method group comparison by log rank test Cox...
Background and Purpose— Mobile stroke units (MSUs) can speed treatment with intravenous tPA (tissue-type plasminogen activator). We previously showed substantial agreement between a telemedicine-based vascular neurologist (TM-VN) an onboard (OB-VN) for the evaluation of patients eligibility on MSU. However, time efficiency remained uncertain. In this study, we examined decision from MSU arrival TM-VN compared OB-VN. Methods— 50 consecutive situations, served as primary maker. Times to bolus...
Background and Purpose- The impact of a mobile stroke unit (MSU) on access to intraarterial thrombectomy (IAT) is prespecified BEST-MSU substudy (Benefits Stroke Treatment Delivered Using Mobile Unit Compared Standard Management by Emergency Medical Services). On the MSU, IAT decision-making steps, such as computed tomography, neurological exam, tPA (tissue-type plasminogen activator) treatment are completed before emergency department arrival. We hypothesized that pre-ED assessment...
Abstract Background Immune checkpoint blockade (ICB) has improved outcomes for patients with microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) tumors. However, not all MSI-H/dMMR will exhibit the same ICB efficacy. Previous studies suggest that concomitant antibiotic use while receiving may result in poorer outcomes. We aimed to evaluate this association metastatic colorectal cancer (mCRC). Materials and Methods A single-site, retrospective review of 57 mCRC received...