A5114833758- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neural Engineering
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
IFOM
2022-2024
University of Milan
2019
Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that characterised by capillary-venous cavernomas, and due to loss-of-function mutations any one of three CCM genes. Familial follows two-hit mechanism similar tumour suppressor genes, while in cavernomas only small fraction endothelial cells shows mutated We reported mouse models human patients, lining the lesions have different features from surrounding endothelium, as they express mesenchymal/stem-cell...
Cerebral cavernous malformations (CCM) are low-flow vascular lesions prone to cause severe hemorrhage-associated neurological complications. Pathogenic germline variants in CCM1, CCM2, or CCM3 can be identified nearly 100% of CCM patients with a positive family history. In line the concept that tumor-like mechanisms involved formation and growth, we here demonstrate an abnormally increased proliferation rate CCM3-deficient endothelial cells co-culture wild-type mosaic human iPSC-derived...
Cerebral cavernous malformations (CCM) are capillary affecting the central nervous system and commonly present with headaches, epilepsy stroke. Treatment of CCM is symptomatic, its prevention limited. often sporadic but sometimes may be multifocal and/or affect multiple family members. Heterozygous pathogenic variants in PDCD10 cause rarest apparently most severe genetic variant familial CCM. We carried out an RNA-Seq a Q-PCR validation analysis Pdcd10-silenced wild-type mouse endothelial...
The blood-spinal cord barrier (BSCB) tightly regulates the transport of molecules from blood to spinal cord. Herein, we present an approach for transient modulation BSCB permeability and localized delivery peptides into behavior with high spatial resolution. This utilizes optical stimulation vasculature-targeted nanoparticles allows BSCB-impermeable without significant glial activation or impact on animal locomotor behavior. We demonstrate minimally invasive light using fiber in lumbar...