A5049335064- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- RNA Research and Splicing
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Caveolin-1 and cellular processes
- Bioinformatics and Genomic Networks
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- PARP inhibition in cancer therapy
- Helicobacter pylori-related gastroenterology studies
- Microtubule and mitosis dynamics
- Circular RNAs in diseases
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
La Trobe University
2021-2024
Olivia Newton-John Cancer Wellness & Research Centre
2021-2024
The Netherlands Cancer Institute
2015
MicroRNA-21 (miR-21) is a small, non-coding RNA overexpressed in gastric cancer and many other solid malignancies, where it exhibits both pro-and anti-tumourigenic properties. However, the pathways regulating miR-21 consequences of its inhibition remain incompletely understood. By exploiting spontaneous Stat3-dependent formation inflammation-associated tumors Gp130F/F mice, we functionally established as Stat3-controlled driver tumor growth progression. We reconciled our discoveries by...
Abstract Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties crosstalk between intestinal tuft cells and type 2 innate lymphoid (ILC2) that evolutionarily optimized for epithelial remodeling in response to helminth infection. We demonstrate cell-derived interleukin 25 (IL25) drives ILC2 activation, inducing release IL13 promoting cell hyperplasia. While resulting - feed-forward...
Abstract Doublecortin‐like kinase 1 (DCLK1) is a putative cancer stem cell marker, promising diagnostic and prognostic maker for malignant tumors proposed driver gene gastric (GC). DCLK1 overexpression in majority of solid cancers correlates with lymph node metastases, advanced disease overall poor‐prognosis. In cells, expression has been shown to promote epithelial‐to‐mesenchymal transition (EMT), driving disruption cell‐cell adhesion, migration invasion. Here, we report that influences...
Doublecortin-like kinase 1 (DCLK1) is a proposed driver of gastric cancer (GC) that phosphorylates serine and threonine residues. Here, we showed the activity DCLK1 orchestrated cell-intrinsic and-extrinsic processes led to pro-invasive pro-metastatic reprogramming GC cells. Inhibition reduced growth subcutaneous xenograft tumors formed from MKN1 human carcinoma cells in mice decreased abundance stromal markers α-Sma, vimentin, collagen. Similar effects were seen with expressing...
Abstract Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here we explore metabolite-triggered circuit between epithelial tuft cells and innate lymphoid type 2 (ILC2) that evolutionarily optimized for intestinal remodeling in response to helminth infection. We demonstrate cell-derived interleukin 25 (IL25) acts as an alarmin on ILC2s induce the release IL13 growth factor cells, propose this model drives early metaplastic tumor...
Deregulation of the Hippo pathway is a driver for cancer progression and treatment resistance. In context gastric cancer, YAP1 biomarker poor patient prognosis. Although genomic tumor profiling provides information activation, present study demonstrates that inhibition Yap1 activity has anti-tumor effects in tumors driven by oncogenic mutations inflammatory cytokines. We show key regulator cell metabolism, proliferation, immune responses normal neoplastic epithelium. propose targetable...
Abstract Gastric cancer (GC) is the 3rd leading cause of mortality worldwide, therefore providing novel diagnostic and treatment options crucial for at risk groups. The serine/threonine kinase doublecortin-like 1 (DCLK1) a proposed driver GC with frequent amplification somatic missense mutations yet molecular mechanism how DCLK1 mediates tumorigenesis poorly understood. We report expression orchestrates complementary cell intrinsic extrinsic processes to comprehensive pro-invasive...
Abstract Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties crosstalk between intestinal tuft cells and type 2 innate lymphoid (ILC2) that evolutionarily optimized for epithelial remodeling in response to helminth infection. We demonstrate cell-derived interleukin 25 (IL25) drives ILC2 activation, inducing release IL13 promoting cell hyperplasia. While resulting - feed-forward...
Specific signalling thresholds of the WNT/β-catenin pathway affect embryogenesis and tissue homeostasis in adult, with mutations this frequently occurring cancer. Excessive activity inhibits murine anterior development associated embryonic lethality accounts for driver event 80% human colorectal cancers. Uncontrolled arises primarily from impairment mutation tumour suppressor gene APC that otherwise prevents prolonged stabilisation β-catenin. Surprisingly, no inhibitor compounds have reached...