A5052932941- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Drug-Induced Adverse Reactions
- Nosocomial Infections in ICU
- Global Maternal and Child Health
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 detection and testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Patient Satisfaction in Healthcare
- Healthcare Systems and Technology
- Listeria monocytogenes in Food Safety
- Radiology practices and education
- Urinary Tract Infections Management
- Appendicitis Diagnosis and Management
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Respiratory Support and Mechanisms
- Hemoglobinopathies and Related Disorders
The University of Sydney
2025
Chelsea and Westminster Hospital NHS Foundation Trust
2019-2024
Glasgow Royal Infirmary
2024
Manchester University NHS Foundation Trust
2024
University of Dundee
2021
National Health and Medical Research Council
2021
Medical Research Council
2021
Association for Clinical Biochemistry and Laboratory Medicine
2021
Imperial College Healthcare NHS Trust
2020
Royal Navy
2020
Since first identified in late 2019, the acute respiratory syndrome coronavirus (SARS-CoV2) and resulting disease (COVID-19) pandemic has overwhelmed healthcare systems worldwide, often diverting key resources a bid to meet unprecedented challenges. To measure its impact on national antimicrobial stewardship (AMS) activities, questionnaire was designed disseminated antimicrobialstewardship leads United Kingdom (UK). Most respondents reported reduction AMS activity with 64% (61/95) reporting...
Oral bowel-cleansing preparations are used before colonic surgery and endoscopic radiological assessment of the intestine to minimise faecal contamination. In February 2009, UK National Patient Safety Agency issued a Rapid Response Report highlighting potential risk harm associated with use these instructing local NHS Trusts implement safeguards reduce this risk. This guidance has been prepared help respond concerns, as complications is influenced by both individual patient factors choice...
Abstract Background We investigated for change in blood stream infections (BSI) with Enterobacterales, coagulase negative staphylococci (CoNS), Streptococcus pneumoniae, and Staphylococcus aureus during the first UK wave of SARS-CoV-2 across five London hospitals. Methods A retrospective multicentre ecological analysis was undertaken evaluating all cultures taken from adults 01 April 2017 to 30 2020 acute hospitals London. Linear trend ARIMA models allowing seasonality were used look...
With increasing frequency of resistant Gram-negative bacteria, temocillin has potential utility in reducing carbapenem use. The 2020 EUCAST guideline changes breakpoints and reclassifies isolates with an MIC 0.001-16 mg/L as 'susceptible, increased exposure' necessitating 6 g/day rather than the previous 4 g/day, associated significant cost implications.We explore clinical treatment failure rate at dosing.All adult inpatient electronic prescriptions (3 days or greater) from March 2016 to...
Antibacterial prescribing in patients presenting with COVID-19 remains discordant to rates of bacterial co-infection. Implementing diagnostic tests exclude infection may aid reduction antibacterial prescribing. (1) Method: A retrospective observational analysis was undertaken all hospitalised across a single-site NHS acute Trust (London, UK) from 1 December 2020 28 February 2021. Electronic patient records were used identify patients, clinical data, and outcomes. Procalcitonin (PCT) serum...
Drug-induced immune haemolytic anaemia (DIIHA) is a rare adverse effect which varies between mild to fatal (Garratty, 2010). One of the most common class drugs reported cause severe DIIHA are second and third generation cephalosporins (e.g. ceftriaxone) 2010, Hill et al., 2017). We report an event severe, life-threatening caused by ceftriaxone administered in ambulatory setting patient via Outpatient Parenteral Antimicrobial Therapy (OPAT) service our subsequent management reaction. A...
Background Black, Asian and minority ethnic (BAME) populations are emerging as a vulnerable group in the severe acute respiratory syndrome coronavirus disease (SARS-CoV-2) pandemic. We investigated relationship between ethnicity health outcomes SARS-CoV-2. Methods findings conducted retrospective, observational analysis of SARS-CoV-2 patients across two London teaching hospitals during March 1 –April 30, 2020. Routinely collected clinical data were extracted analysed for 645 who met study...
Listeriosis is an infective complication that primarily affects pregnant women, patients at extremes of age or those with weakened immune systems. Ingestion food contaminated Listeria monocytogenes the most common source infection, causing self-limiting illness in immunocompetent hosts but associated invasive infection and high mortality high-risk patient groups. Milder presents as gastroenteritis fever, diarrhoea, nausea vomiting 7 days post exposure. Invasive characterised by bacteraemia...
Antimicrobial resistance (AMR) is an ecological and economic crisis stewardship of available antimicrobials required. Electronic prescribing, where available, enables auditing practice, yet in order to be efficient effective addressing inappropriate antimicrobial better use current new technological interventions needed. This retrospective observational evaluation looked at the impact a commercial clinical decision support system (CDSS) on workflow established (AMS) team. Clinical, workflow,...
Acute kidney injury (AKI) is a potential complication of systemic infection. Optimizing antimicrobial dosing in this dynamic state can be challenging with sub- or supra-therapeutic risking treatment failure toxicity, respectively. Locally, unadjusted renal for the first 48 h infection recommended.To determine outcomes associated strategy.A retrospective cohort analysis was undertaken patients treated Gram-negative bacteraemia concurrent non-filtration dependent AKI from single-centre NHS...
European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoint criteria for methicillin-susceptible Staphylococcus aureus (MSSA) treatment with ceftriaxone are based upon high dose (4 g/day) rather than standard (2 posology. This is particularly relevant invasive infections, and patients managed via Outpatient Parenteral Therapy (OPAT), but may result in increased drug toxicity. We quantified the incidence of neutropenia, thrombocytopenia raised liver enzymes between adult...
Appendicitis remains a common surgical emergency in children. Empirical antibacterial treatment is indicated to reduce infective complications. We investigate the bacterial pathogens identified intra-operatively during appendectomies children guide empirical antimicrobial prophylaxis options.A retrospective analysis of patients (< 18 years old) undergoing an appendectomy across multisite London hospital (Nov 2019-March 2022) was undertaken. Patient-related outcomes including length stay...
Abstract Background Antimicrobial resistance in Neisseria gonorrhoeae is a global public health concern. Tetracycline (TetR) increased from 39.4% to 75.2% between 2016 and 2021 N. isolates collected through national surveillance England, despite the absence of use tetracyclines for treatment gonorrhoea. Objectives We investigated whether there was correlation bacterial sexually transmitted infection (STI) tests performed with antimicrobials, TetR gonorrhoeae. Methods examined correlations...
Eosinophilic gastroenteritis is a condition characterised by eosinophilic infiltration of the gastrointestinal tract. Biliary obstruction an unusual presentation. A case where initial investigations were consistent with carcinoma head pancreas but resection specimen showed no malignancy presented. The diagnosis was suspected from review patient's past history and confirmed re-examination histology.
In 2019, the European Union banned Triton X-100, a detergent widely used in laboratory diagnostics, including Viral PCR Sample Solution (VPSS), and urged manufacturers to find environmentally sustainable alternatives. Tergitol 15-S-9 (VPSS2) has been proposed as an alternative surfactant. This multicenter study evaluated effectiveness of VPSS2, Tergitol-based viral solution, replacement for VPSS. Our results show equivalent performance VPSS2 VPSS nucleic acid extraction stability over time...
<title>Abstract</title> Background: Antibacterial prescribing in patients presenting with COVID-19 remains discordant to rates of bacterial co-infection. Implementing diagnostic tests exclude infection may aid reduction antibacterial prescribing. Method: A retrospective observational analysis was undertaken all hospitalised across a single-site NHS acute Trust (London, UK) from 01/12/20-28/2/21. Electronic patient records were used identify patients, clinical data, and outcomes....