A5073486382- Comparative constitutional jurisprudence studies
- Plant biochemistry and biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Human Rights and Immigration
- Spanish Literature and Culture Studies
- Legal processes and jurisprudence
- Social Sciences and Policies
- Political Theory and Democracy
- Microbial Natural Products and Biosynthesis
- Alcohol Consumption and Health Effects
- Natural product bioactivities and synthesis
- Spanish Culture and Identity
- Tracheal and airway disorders
- Biofuel production and bioconversion
- Economic and Social Development
- Media, Journalism, and Communication History
- Probiotics and Fermented Foods
- Oral and gingival health research
- Employment, Labor, and Gender Studies
- Journalism and Media Studies
- Cleft Lip and Palate Research
- Criminal Justice and Penology
- Biochemical and biochemical processes
- Genomics and Rare Diseases
- Gender and Feminist Studies
Universidad Politécnica de Madrid
2024
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2020-2022
Centrale Marseille
2019
Centre National de la Recherche Scientifique
2019
Aix-Marseille Université
2019
Instituto de Agroquímica y Tecnología de Alimentos
2010-2015
Consejo Superior de Investigaciones Científicas
2008-2015
University of Cambridge
2015
Universidad de Granada
1988-1995
ABSTRACT Linalool production was evaluated in different Saccharomyces cerevisiae strains expressing the Clarkia breweri linalool synthase gene ( LIS ). The wine strain T 73 shown to produce higher levels of than conventional laboratory (i.e., almost three times amount). performance this further enhanced by manipulating endogenous mevalonate (MVA) pathway: deregulated overexpression rate-limiting 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) doubled production. In a...
Monoterpenes are important contributors to grape and wine aroma. Moreover, certain monoterpenes have been shown display health benefits with antimicrobial, anti-inflammatory, anticancer or hypotensive properties amongst others. The aim of this study was construct self-aromatizing yeasts overproduce de novo these plant metabolites in wines. Expression the Ocimum basilicum (sweet basil) geraniol synthase (GES) gene a Saccharomyces cerevisiae strain substantially changed terpene profile...
Terpenes are industrially relevant natural compounds the biosynthesis of which relies on two well-established—mevalonic acid (MVA) and methyl erythritol phosphate (MEP)-pathways. Both pathways widely distributed in all domains life, former is predominantly found eukaryotes archaea latter eubacteria chloroplasts. These supply isopentenyl diphosphate (IPP) dimethylallyl (DMAPP), universal building blocks terpenes. The potential to establish a semisynthetic third pathway access these precursors...
All naturally produced terpenes are derived from two universal C5 diphosphate precursors, dimethylallyl (DMAPP) and isopentenyl (IPP). Various prenyl transferases use DMAPP to prenylate aromatic compounds, while others, in combination with IPP, lead the enzymatic formation of geranyl (GPP), farnesyl (FPP), geranylgeranyl (GGPP), geranylfarnesyl diphosphate, direct precursors monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), sesterterpenes (C25), respectively. FPP GGPP also basis...
Abstract Background Parents of children who have a congenital anomaly can experience significant worry about their child’s health. Access to clear, helpful, and trustworthy information provide valuable source support. In this study the aim was explore needs parents/carers with anomalies across Europe. Method A cross-sectional online survey developed in nine languages measure parents’ needs, including: (1) ‘helpfulness’/’trustworthiness’ received from eight relevant sources, (2) overall...
Abstract Background Rare diseases present a wide spectrum of clinical manifestations and severity levels are often poorly known underrepresented, making them difficult to classify. Diagnoses usually coded using the International Classification Diseases (ICD), with its different versions. In Spain, ICD-10-ES (stem from ICD-10-CM–Clinical Modification) is used throughout National Healthcare System since 2016, indistinctively including rare that lack specific code. Orphanet aims provide...
Abstract The engineering of genetic circuits to perform predefined computations is central synthetic biology, enabling living cells with new functionalities applicable across various domains. However, these are often specifically tailored particular cellular hosts, Escherichia coli being the most popular. Consequently, their intended functions may not translate well other organisms, limiting scope. Understanding circuit dynamics in less familiar organisms crucial, especially for...
Abstract BackgroundRare diseases present a wide spectrum of clinical manifestations and severity levels, their main common trait is the low prevalence, making them difficult to classify. Diagnoses are usually coded using International Classification Diseases (ICD), with its different versions. In Spain, ICD-10-ES (stem from ICD-10-CM–Clinical Modification) used throughout National Healthcare System since 2016, indistinctively including rare that often lack specific code. ORPHAcode aims...
Abstract Background Parents of children who have a congenital anomaly can experience significant worry about their child’s health. Access to clear, helpful, and trustworthy information provide valuable source support. In this study the needs parents/carers with anomalies were explored across Europe. Method A cross-sectional online survey was developed in nine languages measure parents’ needs, including: (1) ‘helpfulness’/’trustworthiness’ received from eight relevant sources, (2) overall...