A5058714170- Renal Transplantation Outcomes and Treatments
- Carcinogens and Genotoxicity Assessment
- Pharmacological Effects and Toxicity Studies
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Insect and Pesticide Research
- Skin and Cellular Biology Research
- Pesticide Exposure and Toxicity
- Insect Pest Control Strategies
- Metabolism and Genetic Disorders
- Pesticide and Herbicide Environmental Studies
- Protein Tyrosine Phosphatases
- HIV/AIDS drug development and treatment
- Pesticide Residue Analysis and Safety
- Hemoglobinopathies and Related Disorders
- Biochemical and Molecular Research
- Genomics and Rare Diseases
- Acute Lymphoblastic Leukemia research
- Hippo pathway signaling and YAP/TAZ
- Nuclear Structure and Function
- Phenothiazines and Benzothiazines Synthesis and Activities
- Glutathione Transferases and Polymorphisms
- Congenital heart defects research
- Medicinal Plants and Neuroprotection
- Genomic variations and chromosomal abnormalities
University of Monastir
2012-2024
Hospital Fatuma Bourguiba Monastir
2015-2021
The present study investigated in Tunisian renal transplant patients, genetic polymorphisms of CYP3A4 -392A>G and CYP3A5 6986A>G their influence on tacrolimus (Tac) pharmacokinetics during early late post-transplant (PT) phases established customized ranges Tac doses matching the C0 target levels according to genotype combination PT phase.We included adult patients having received for de novo kidney grafts undergone a therapeutic drug monitoring by morning (1 90 days) (over phases. genomic...
Of all workers exposed globally to synthetic sources of radiation, medical personnel represent the largest group, but receive relatively low doses. Accidental or therapeutic acute radiation exposure humans was observed induce various forms cytogenetic damage, including possibility increasing incidence micronuclei (MN) and chromosomal aberrations (CA). The aim this study assess occupationally induced damage in a large population hospital doses ionizing (IR). cytokinesis-block MN comet assays...
Human cytochrome P450 (CYP), particularly CYP3A4 and CYP3A5 is mainly responsible for the metabolism of several drugs including tacrolimus. Significant interracial/interethnic variation in expression function caused by Single Nucleotide Polymorphisms (SNPs) genes encoding these proteins.
Genetic diseases in the Tunisian population represent a real problem of public health as their spectrum encompasses more than 400 disorders. Their frequency and distribution country have been influenced by demographic, economic social features especially consanguinity. In this article, we report on genetic disease association referred to comorbidity discuss factors influencing expressivity. Seventy-five associations reported among families. This could be individual or familial. 39 comorbid...
Summary Charcot‐Marie‐Tooth (CMT) disease constitutes a clinically and genetically heterogeneous group of hereditary neuropathies characterized by progressive muscular sensory loss in the distal extremities with chronic weakness, deformation feet, deep tendon reflexes. CMT4H is an autosomal recessive demyelinating subtype CMT, due to mutations FGD4/FRABIN , for which nine are described date. In this study, we describe three patients from consanguineous Tunisian family, presenting severe,...
Objective: To investigate the potential adverse effects of imidacloprid on biochemical parameters, oxidative stress and liver damage induced in rat by oral sub-chronic imidaclopride exposure.Methods: Rats received three different doses (1/45, 1/22 1/10 LD 50 ) given through gavage for 60 days.Two dozen male Wistar rats were randomly divided into four experimental groups.Liver was determined measuring aspartate aminotransferase, alanine alkaline phosphatase lactate dehydrogenase leakages.The...
<b><i>Background:</i></b> Digoxin is a substrate of P-glycoprotein (P-gp) and organic anion transporting polypeptide transporters that are encoded by <i>ABCB1</i> <i>SLCO1B3</i> genes. Genetic polymorphisms in both genes may explain inter-individual variability serum digoxin concentration (SDC). This study evaluates the possible effect most common on SDC after single oral dose Tunisian atrial fibrillation (AF) patients....
Abstract: Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs. Significant interethnic variation expression TPMT ITPA is caused by single nucleotide polymorphisms genes encoding these proteins. The aim this study was to describe distribution healthy Tunisian subjects establish metabolizer status drugs population. A total 309 were recruited among blood donors Fattouma Bourguiba Hospital...
Recent studies have suggested an association between mutations in the IL-36RN gene and onset of pustular generalized. In literature, only one case acute generalized exanthematous pustulosis (AGEP) induced by codeine a patient with IL36RN mutation has been reported. Herein, we reported unusual AGEP caused history psoriasis confirmed oral provocation test. this case, shown that is not constant condition drug-induced AGEP. Clinicians should be aware side effect especially, patients psoriasis....
The mitochondrial DNA (mtDNA) variant T16189C has been investigated in several metabolic diseases. In this study, we aimed to estimate the frequency of Tunisian and other Mediterranean populations evaluate impact on phylogeny populations. Blood sample 240 unrelated subjects were recruited from localities. hypervariable region 1 mtDNA amplified sequenced. Additional sequences (N = 4921) compiled previous studies. average Tunisia (29%) is similar that observed North African Near Eastern Our...