A5011947087- Virtual Reality Applications and Impacts
- Traumatic Brain Injury Research
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Digital Mental Health Interventions
- Functional Brain Connectivity Studies
- Spatial Cognition and Navigation
- Human-Automation Interaction and Safety
- Simulation-Based Education in Healthcare
- Mental Health Research Topics
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Memory and Neural Mechanisms
- Posttraumatic Stress Disorder Research
- Stroke Rehabilitation and Recovery
- Neural dynamics and brain function
- Neuroethics, Human Enhancement, Biomedical Innovations
- Cognitive Science and Mapping
- HIV Research and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Mind wandering and attention
- Social Robot Interaction and HRI
- Lipid Membrane Structure and Behavior
- Cognitive Functions and Memory
- Autism Spectrum Disorder Research
University of Pennsylvania
2007-2025
University of Exeter
2023-2025
Arizona State University
2022-2024
Universitat Politècnica de València
2024
University Hospital Mútua de Terrassa
2024
Mútua Terrassa
2024
Grace (United States)
2022-2024
University of North Texas
2014-2023
657 Oslo
2020
NetDragon (United States)
2018-2019
We recently described a severe, potentially lethal, but treatment-responsive encephalitis that associates with autoantibodies to the NMDA receptor (NMDAR) and results in behavioral symptoms similar those obtained models of genetic or pharmacologic attenuation NMDAR function. Here, we demonstrate patients' antibodies cause selective reversible decrease surface density synaptic localization correlates antibody titers. The mechanism this is antibody-mediated capping internalization NMDARs, as...
Objectives: HAART suppresses HIV viral replication and restores immune function. The effects of on neurological disease are less well understood. aim this study was to assess the prevalence incidence neurocognitive impairment in individuals who initiated as part an AIDS clinical trial. Design: A prospective cohort HIV-positive patients enrolled randomized antiretroviral trials, Clinical Trials Group (ACTG) Longitudinal Linked Randomized (ALLRT) study. Methods: We examined association between...
Objective A severe but treatable form of immune‐mediated encephalitis is associated with antibodies in serum and cerebrospinal fluid (CSF) against the GluN1 subunit N‐methyl‐D‐aspartate receptor (NMDAR). Prolonged exposure hippocampal neurons to from patients anti‐NMDAR caused a reversible decrease synaptic localization function NMDARs. However, acute effects antibodies, fate internalized receptors, type affected, whether develop compensatory homeostatic mechanisms were unknown are focus...
ABSTRACT Treatment and rehabilitation of the cognitive, psychological, motor sequelae central nervous system dysfunction often relies on assessment instruments to inform diagnosis track changes in clinical status. Typically, these assessments employ paper-and-pencil psychometrics, hands-on analog/computer tests, rating behavior within context real-world functional environments. Virtual reality offers option produce distribute identical “standard” simulation environments which performance can...
The emergence of social neuroscience has significantly advanced our understanding the relationship that exists between processes and their neurobiological underpinnings. Social research often involves use simple static stimuli lacking many potentially important aspects real world activities interactions. Whilst this merit, there is a growing interest in presentation dynamic manner allows researchers to assess integrative carried out by perceivers over time. Herein, we discuss potential...
In this initial pilot study, a controlled clinical comparison was made of attention perforance in children with deficit-hyperactivity disorder (ADHD) virtual reality (VR) classroom. Ten boys diagnosed ADHD and ten normal control participated the study. Groups did not significantly differ mean age, grade level, ethnicity, or handedness. No participants reported simulator sickness following VR exposure. Children exhibited more omission errors, commission overall body movement than were...
The current project is an initial attempt at validating the Virtual Reality Cognitive Performance Assessment Test (VRCPAT), a virtual environment-based measure of learning and memory. To examine convergent discriminant validity, multitrait-multimethod matrix was used in which we hypothesized that VRCPAT's total memory scores would correlate with other neuropsychological measures involving but not potential confounds (i.e., executive functions; attention; processing speed; verbal fluency)....
A closed-loop system that offers real-time assessment and manipulation of a user's affective cognitive states is very useful in developing adaptive environments which respond rational strategic fashion to changes user affect, cognition, motivation. The goal progress the from suboptimal toward an optimal state enhances performance. In order achieve this, there need for both 1) affective/cognitive 2) observed state. This paper presents approaches assessing these two states. Arousal, important...
Autoimmune-mediated anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis is a severe but treatment-responsive disorder with prominent short-term memory loss and seizures. The mechanisms by which patient antibodies affect synapses neurons leading to symptoms are poorly understood.The effects of on cultures live rat hippocampal were determined immunostaining, Western blot, electrophysiological analyses.We show that cause selective decrease in the total...
Clinical neuropsychologists have long underutilized computer technologies for neuropsychological assessment. Given the rapid advances in technology (e.g. virtual reality; tablets; iPhones) and increased accessibility past decade, there is an on-going need to identify optimal specifications advanced while minimizing potential sources of error. Herein, we discuss concerns raised by a joint American Academy Neuropsychology/National Neuropsychology position paper. Moreover, proffer parameters...
Advances in affective computing technologies have made it possible for researchers to investigate brain function while users interact virtual environments. Progress sensors and algorithms off-the-shelf EEG systems has gaming perform real-time estimation of human cognitive states using EEG. In this study our aim was coordinate "Task Engagement" data with "Arousal-Valence" data. The resulting designed application expressive transformations video game play real time by tuning different...