1. Severe, ischaemic, acute tubular necrosis was induced in rats by bilateral occlusion of the renal arteries. The experimental group received exogenous epidermal growth factor infused directly into arterial circulation. Serum creatinine concentration measured daily for 1 week. Epidermal receptor binding autoradiography whole kidney sections. Renal cell proliferation incorporation [3H]thymidine DNA. 2. increased after with a peak at 48 h and remained elevated above control levels 7 days....

Effective treatment of acute lobar nephronia (ALN) can prevent its progression to renal abscess. The goal this prospective study was compare the efficacy for pediatric patients who had ALN with a 3- vs 2-week intravenous plus oral antimicrobial-therapy regimen.Patients were suspected having an upper urinary tract infection underwent systematic scheme ultrasonographic and computed tomographic (CT) evaluation diagnosis. Patients positive CT findings enrolled randomly allocated serial entry...

OBJECTIVE. The goal was to examine bacterial antimicrobial resistance of recurrent urinary tract infections in children receiving antibiotic prophylaxis because primary vesicoureteral reflux. METHODS. We reviewed data retrospectively for with documented reflux 2 hospitals during a 5-year follow-up period. patients were co-trimoxazole, cephalexin, or cefaclor sequence different antibiotics (alternative monotherapy). Demographic data, degree reflux, prophylactic prescribed, and sensitivity...

Background. Correct identification of acute lobar nephronia (ALN) is necessary to prevent progression renal abscess. The goal this retrospective study was determine whether the sonographic finding severe nephromegaly (i.e. length greater than mean + 3 sd) a preselection criterion for computed tomographic (CT) scanning in diagnosing pediatric ALN among children with an upper urinary tract infection. Design/methods. We evaluated new imaging work-up scheme detect ALN. All patients infection...

Renal abscess is a rare disease in childhood and early diagnosis essential to minimize the renal damages. Experiences gained from this 10-year study on patients with CT-proved include varied clinical presentations use of sonographic-marked nephromegaly focal mass as indications for further CT diagnosis.

<i>Background/Aim:</i> Renal replacement therapies (RRTs) have been used for the acute management of inborn errors metabolism. Hemodialysis is most effective modality. The aim this article to demonstrate that high-volume hemofiltration can offer an alternative way effectively remove small molecules. <i>Methods:</i> Eight patients presented with neurological deterioration due ammonia or organic acid accumulation. Different RRTs were applied, including continuous...

To compare the incidence of hepatitis B virus (HBV)-associated membranous nephropathy (HBVMN) before and after universal HBV vaccination to identify factors underlying change.This study included 471 hospitalized children with nephrotic syndrome (NS) 488 long-term follow-up surface antigen (HBsAg)-carrier children. Horizontal transmission (negative maternal HBsAg status) HBVMN was assessed, compared initiation program started in 1984.The frequency NS 11.6% between 1974 1984, 4.5% 1984 1994,...

Background: Acute lobar nephronia (ALN) is a complicated acute renal infection that part of the progression inflammatory process pyelonephritis can progress to abscess if left untreated. We examined place ALN in spectrum upper urinary tract infections. Methods: The medical records all patients diagnosed with by computed tomography (CT) were reviewed retrospectively terms their demographic characteristics, clinical presentations, and laboratory findings. patterns lesions checked on...

Acute lobar nephronia (ALN) is a severe nonliquefactive inflammatory renal bacterial infection, and requires longer duration of treatment. The aim this prospective study was to investigate scarring after ALN examine the risk factors for in children with compared those acute pyelonephritis (APN).Patients computed tomography-diagnosed were enrolled randomly allocated, serial entry, either 2- or 3-week antibiotic treatment regimen. Age- gender-matched APN patients served as comparators....

Objective: To assess age- and sex-specific serum creatinine levels in a pediatric population using hospital-based database Taiwan. Study Design: Data on were obtained from the National Taiwan University Hospital-integrated Medical Database (NTUH-iMD). Due to possibility of having acute kidney injury or chronic disease, individuals with multiple measurements excluded, outliers each group also subsequently removed. The remaining analyzed, 95% reference limits established. Results: Serum data...

Background: Patient susceptibility to bacterial urinary tract infections, which is determined by complex pathogen-host interactions, varies between individuals due genetic variation. The neutrophil-dependent innate immune system an important part of keeping the sterile. This study was performed explore single nucleotide polymorphisms (SNPs) in genes associated with immunity pediatric patients severe parenchymal infections. Methods: subjects included who fulfilled diagnostic criteria acute...

Deferasirox is a new oral iron chelating agent with several cases reporting renal adverse events in recent years. Our aim was to identify the incidence of deferasirox-related Fanconi syndrome (FS) and its risk factors.All transfusion-dependent thalassaemic patients who received deferasirox at outpatient department National Taiwan University Hospital (NTUH) from January 2006 February 2014 were evaluated.This cohort study included 57 patients, mean age initiation 18.2 ± 7.7 After 6.9 1.8 years...

Despite recent advances in molecular epidemiology and pathogenecity analyses of extraintestinal Escherichia coli infections, detailed identifying virulence factors E. isolates from pediatric urosepsis patients have not been reported. This study was conducted to explore differentiate bacterial associated with 2 other severe parenchymal acute pyelonephritis (APN) lobar nephronia (ALN), patients.Patients included this were those who fulfilled the diagnostic criteria urosepsis, APN, ALN, without...

Patients with a relapse of idiopathic nephrotic syndrome have significantly increased levels serum complement component 5a (C5a), and proteinuria has been noted in mice treated C5a via changes permeability kidney endothelial cells (KECs) established animal models. However, the apoptosis KECs high concentrations also observed. As mitochondrial damage is known to be important cell apoptosis, aim this study was examine association between C5a-induced mouse KEC damage. Mouse were isolated...

We determined whether nephromegaly on ultrasound can be used to identify patients with urinary tract infection at increased risk for renal scarring, and we investigated the effect of vesicoureteral reflux scarring.We enrolled hospitalized a first febrile infection. All underwent most voiding cystourethrography. Renal scarring was assessed using (99m)technetium dimercapto-succinic acid scintigraphy least 6 months after treatment. Children recurrent infections before were excluded from study.A...

To assess postnatal kidney volume development and to compare the intrauterine extrauterine growth curves of premature infants.One hundred neonates were enrolled in this study, all infants had their volumes measured by renal ultrasound examination. Group GA consisted 44 who evaluated within 48 h after birth, gestational ages used analysis. CA included 56 born before 34 weeks gestation was 14-96 days conceptional Left volume, body weight, height age correlation analysis.There a better rate for...